Nasal T-cell lymphoma causally associated with Epstein-Barr virus: Clinicopathologic, phenotypic, and genotypic studies

Harabuchi, Yasuaki; Imai, Shosuke; Wakashima, Junichi; Hirao, Motoyasu; Kataura, Akikatsu; Õsato, Toyoro; Kon, Shinichiro

doi:10.1002/(sici)1097-0142(19960515)77:10<2137::aid-cncr27>3.0.co;2-v

Cited by 139 publications

(76 citation statements)

References 46 publications

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“…With regard to NHL in head and neck lesions, we and other investigators showed poorer prognosis of nasal T-cell lymphoma (4,6,19). In this study T-cell lymphomas arising from WR have been shown to have an aggressive clinical course compared with B-cell lymphomas.…”

Section: Discussionsupporting

confidence: 56%

Prognostic Factors and Treatment Outcome in Non-Hodgkin's Lymphoma of Waldeyer's Ring

et al. 1997

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Section: Discussionsupporting

confidence: 56%

Prognostic Factors and Treatment Outcome in Non-Hodgkin's Lymphoma of Waldeyer's Ring

et al. 1997

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“…An angiocentric pattern of proliferation is regarded to be characteristic [13][14][15], and this was found in 48% of nasal type cases, but less frequently in cases of non-nasal (27%) and nodal type (20%). Although the frequency of mitotic figures was rather similar among each type of NK/T-cell lymphoma, the Ki-67 index was slightly higher in the non-nasal (74%) and nodal type (73%) than in the nasal type (61%).…”

Section: Discussionmentioning

confidence: 99%

NK‐cell related neoplasms in Osaka, Japan

et al. 2004

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The frequency of NK-cell related neoplasms was estimated among lymphoproliferative diseases diagnosed and treated in Osaka, Japan, from 1999 to 2003. The total number of registered cases was 1,400, among which 1,092 patients were diagnosed as having malignant lymphomas. There were 987 cases of non-Hodgkin's lymphoma (NHL) and 105 (9.6%) of Hodgkin's lymphoma. Immunophenotypic analysis revealed that 743 patients had B-cell lymphomas and 209 T/NK-cell lymphomas. Among the T/NK-cell lymphomas, 40 showed positive immunoreactivity for CD56, and thus they were judged to be NK/T-cell lymphomas. They included one blastic NK-cell lymphoma and 39 NK/Tcell lymphomas. NK/T-cell lymphomas were further divided into three categories based on the main site of lesions: nasal type (23 cases), non-nasal extranodal type (11 cases), and nodal type (5 cases). The positive rate of infection with the Epstein-Barr virus determined by in situ hybridization was 83%, 36%, and 25% in the nasal, non-nasal, and nodal type, respectively. A mosquito allergy was found in one patient with EBVpositive non-nasal NK/T-cell lymphoma. The present study showed that the frequency of NK-cell related neoplasms among all NHLs was 4% in an ATL-non-endemic area of Japan.

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“…Clinically, NNKTL is characterized by progressive necrotic lesions in the nasal cavity and a poor prognosis caused by rapid progression [1,2]. The original cells of NNKTL are reported to be natural killer (NK)-cells or gamma delta T-cell lineages [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…We have previously indicated the presence of Epstein-Barr virus (EBV) DNA, EBV oncogenic proteins, and the clonotypic EBV genome in NNKTL [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T-cell lymphoma cells Miki Takahara 1) , Toshihiro Nagato 1) , Yuhki Komabayashi 1) , Kazumi Yoshino 1) , Seigo Ueda 1) , Kan Kishibe 1) , and Yasuaki Harabuchi 1) Abstracts Nasal natural killer/T-cell lymphoma (NNKTL) is associated with the Epstein-Barr virus (EBV), and has distinct histological features such as angiocentric and polymorphous lymphoreticular infiltrates that contain too many cell types, including tumour and inflammatory cells. We have previously shown that intercellular adhesion molecule (ICAM)-1 is expressed in NNKTL cells, and that soluble ICAM-1 (sICAM-1) is significantly increased in patients' sera.…”

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confidence: 99%

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Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T cell lymphoma cells

Takahara

Nagato

Komabayashi

et al. 2013

Experimental Hematology

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Nasal T-cell lymphoma causally associated with Epstein-Barr virus: Clinicopathologic, phenotypic, and genotypic studies

Cited by 139 publications

References 46 publications

Prognostic Factors and Treatment Outcome in Non-Hodgkin's Lymphoma of Waldeyer's Ring

Prognostic Factors and Treatment Outcome in Non-Hodgkin's Lymphoma of Waldeyer's Ring

NK‐cell related neoplasms in Osaka, Japan

Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T cell lymphoma cells

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