Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report

Abstract

Patient: Male, 25Final Diagnosis: Nasal type • extra nodal NK/T-cell lymphomaSymptoms: Left periorbital swelling • redness • pain for 25 days • yellowish eye discharge associated • headache • feverMedication: —Clinical Procedure: —Specialty: OtolaryngologyObjective:Unusual clinical courseBackground:Extranodal lymphoma of the paranasal sinuses is a rare clinical entity seen in only 5–8% of extranodal lymphomas of the head and neck. Nasal natural killer/T cell lymphoma (Nasal NKTCL), which is a subtype of peripheral T cell lymphoma, constitutes about 1.4% of all lymphomas. NKTCL is usually diagnosed at a late stage because it presents with nonspecific symptoms in the early stages.Case Report:We report the case of a 25-year-old male patient who presented with periorbital swelling treated as fungal sinusitis but proven to have NKTCL. We review the literature and discuss the clinical manifestations of the disease, its relation to EBV virus, the histological and radiological characteristics, the prognostic indicators, and treatment options. This case report shows physicians that NKTCL lymphoma can present as periorbital cellulitis, although few similar cases are found in the literature.Conclusions:NKTCL is a destructive midline tumor that should be kept in mind as a differential diagnosis of paranasal sinus lesions to help in early diagnosis, which can improve the prognosis.

Extranodal Natural Killer/t-cell Lymphoma Nasal Type With Extensive Ocular Tissue Involvement: A Case Report

“…[1,2] We experienced a rare case of nasal ENKTL related to ocular including conjunctiva, ciliary body, vitreous and retina. To the best of our knowledge, there have been several case reports and case series of NKTL with ocular involvement published, [3][4][5][6][7][8][9][10][11][12][13][14] and our case was the rst one which reported nasal NKTL with involvement of both intraocular with ciliary body related and orbit soft tissue.…”

Cutaneous extranodal natural killer/T-cell lymphoma mimicking cellulitis: A unique presentation

“…Serum lactate dehydrogenase is often elevated and associated with decreased survival along with increasing age, tumor stage, extranodal involvement, lymphadenopathy, and EBV DNA level. 8 Radiation may be used concurrently with chemotherapy in early disease; however, radiation alone results in high rates of relapse. Progressive disease requires multidrug treatment and often autologous hematopoietic stem cell transplantation.…”

A Great Masquerader: Nasal Type, Extranodal Natural Killer/T-cell Lymphoma Presenting as Recalcitrant Bacterial Sinusitis and Periorbital Cellulitis

“…Clinical manifestations of nasal ENKL include signs and symptoms of recurrent chronic sinusitis, periorbital swelling, chemosis, or proptosis [ 3 , 4 ]. Rarely, there have been reported cases of periorbital involvement without sinusitis [ 5 ]. The diagnosis of nasal ENKL is almost always delayed because of its rarity and oftentimes treated as chronic or acute on chronic sinusitis during initial presentation.…”