Nasal-Type NK/T-Cell Lymphoma Involvement of the Vocal Cord on FDG PET/CT

Huang, Mingxing; Wang, Rang; Shen, Guohua; Tian, Rong

doi:10.1097/rlu.0000000000004276

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Filizoglu et al ( 8 ) reported a unique case of ENKTCL with widespread cutaneous and subcutaneous involvement. Huang et al ( 30 ) reported a case of ENKTCL involving the left vocal cord, which showed focal FDG uptake on PET/CT. All of the above highlight the value of 18 F-FDG-PET/CT in ENKTCL diagnosis and staging.…”

Section: Discussionmentioning

confidence: 99%

Multimodality imaging evaluation of primary testicular extranodal natural killer/T-cell lymphoma: two case reports

Huang

Liu

et al. 2023

Front. Med.

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BackgroundExtranodal natural killer/T-cell lymphoma (ENKTCL) is a distinct pathological entity and accounts for ~10% of T-cell lymphomas. The histological features of ENKTCL include angiodestruction and coagulative necrosis and the association with EBV infection. ENKTCL is typically aggressive and mainly affects the nasal cavity and nasopharyngeal region. However, some patients can present with distant nodal or extranodal involvement such as the Waldeyer ring, gastrointestinal tract, genitourinary organs, lung, thyroid, skin, and testes. Compared to ENKTCL of nasal type, primary testicular ENKTCL is very rare and has a lower age of onset and faster clinical progression, with tumor cell dissemination occurring early in the disease.Case reportCase 1: A 23-year-old man presented with 1 month of right testicular pain and swelling. Enhancement CT revealed increased density in the right testis, uneven increased enhancement, discontinuity of the local envelope, and multiple trophoblastic vessels in the arterial phase. Testicular ENKTCL was diagnosed by post-operative pathology. The patient underwent a follow-up 18F-FDG PET/CT imaging 1 month later and found elevated metabolism in the bilateral nasal, left testicular, and right inguinal lymph nodes. Unfortunately, the patient received no further treatment and died 6 months later. Case 2: A 2-year-old male child presented with an enlarged right testicle, MRI showed a mass in the right epididymis and testicular area, which showed low signal on T1WI, high signal on T2WI and DWI, and low signal on ADC. Meanwhile, CT showed soft tissue in the lower lobe of the left lung and multiple high-density nodules of varying sizes in both lungs. Based on the post-operative pathology, the lesion was diagnosed with primary testicular ENKTCL. The pulmonary lesion was diagnosed as hemophagocytic lymphohistiocytosis associated with EBV infection. The child was given SMILE chemotherapy, but pancreatitis was induced during chemotherapy, then he died 5 months later after chemotherapy.ConclusionPrimary testicular ENKTCL is very rare in clinical practice, typically presenting as a painful testicular mass, which can mimic inflammatory lesions and cause diagnostic challenges. 18F-FDG PET/CT plays pivotal roles in the diagnosis, staging, evaluation of treatment outcomes and prognosis evaluation in patients with testicular ENKTCL, and it is helpful to assist clinical practice to better formulate individualized treatment plans.

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Section: Discussionmentioning

confidence: 99%

Multimodality imaging evaluation of primary testicular extranodal natural killer/T-cell lymphoma: two case reports

Huang

Liu

et al. 2023

Front. Med.

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“…Transverse CT ( E ) at the level of the hyoid and corresponding fused PET/CT ( F ) images showed enlargement and hypermetabolism of the right aryepiglottic fold (arrowhead). Transverse CT ( G ) at the level of the ventricular cord and corresponding fused PET/CT ( H ) images showed thickness and hypermetabolism of the right ventricular cord (arrowhead) 4 . Transverse CT ( I ) at the level of the aortic arch and corresponding fused PET/CT ( J ) showed hypermetabolism of the irregularly thickened esophageal wall (arrowhead).…”

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confidence: 99%

FDG PET/CT in a Case of Esophageal Extranodal NK/T-Cell Lymphoma, Nasal Type

Zhang¹,

Dong³

et al. 2023

Clin Nucl Med

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Lymphoma involving the esophagus is rare. We describe FDG PET/CT findings in a case of extranodal NK/T-cell lymphoma, nasal type involving the larynx, hypopharynx, and cervical and upper thoracic esophagus. The esophageal tumor showed segmentally increased FDG uptake mimicking esophagitis. This case indicates that esophageal lymphoma should be included in the differential diagnosis of the hypermetabolic esophageal diseases.

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Nasal-Type NK/T-Cell Lymphoma Involvement of the Vocal Cord on FDG PET/CT

Cited by 2 publications

References 18 publications

Multimodality imaging evaluation of primary testicular extranodal natural killer/T-cell lymphoma: two case reports

Multimodality imaging evaluation of primary testicular extranodal natural killer/T-cell lymphoma: two case reports

FDG PET/CT in a Case of Esophageal Extranodal NK/T-Cell Lymphoma, Nasal Type

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