Nasal vestibule squamous cell carcinoma: a population-based cohort study from DAHANCA

Filtenborg, Mads V; Lilja-Fischer, J.; Sharma, M.B.; Primdahl, Hanne; Kjems, Julie; Plaschke, Christina Caroline; Charabi, Birgitte; Kristensen, Claus Andrup; Andersen, Maria; Andersen, Elo; Godballe, Christian; Johansen, Jørgen; Overgaard, Jens; Petersen, Kristian Kjær

doi:10.1080/0284186x.2021.1994646

Cited by 12 publications

(22 citation statements)

References 25 publications

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“…Chabrillac 21 demonstrated that positive margins after TR were predictive of tumor recurrence; age was found to significantly correlate with OS at both uni-and multivariable analysis by Filtenborg. 17 Similar results were presented in our series, as positive margins were associated with worse DSS (p = 0.018), as well as age was associated with worse OS and DFS at both uni-and multivariable analysis. Dowley 3 reported that deep tissues involvement at the level of the septum and columella, particularly around the anterior nasal spine (i.e., T2 or T3 by Wang's system) had worse prognosis.…”

Section: Discussionsupporting

confidence: 89%

“…Locoregional control at 5 years was 67 AE 4%, DSS was 74% and OS 50%. Similar results were found by Filtenborg 17 from 162 patients included in the clinical database DAHANCA, that showed an OS of 60% at 5 years of follow-up. In their subset of 146 (90%) patients treated with curative intent, disease-specific mortality at 5 years was 11% and OS was 65%.…”

Section: Discussionsupporting

confidence: 88%

“…18 The Wang system was proposed in 1976, and even though it was based on a group of only 36 patients, it is still considered the most proper since it was specifically designed for NV tumors. 16,17 However, in 1999, Horsman 19 applied the Wang classification to 66 patients with NV-SCC (cT1 = 55%; cT2 = 35%; cT3 = 11%) and found there was no significant prognostic value. Interestingly, in their series, gender, age, T-status, tumor volume, surgical margins, and primary treatment did not correlate with survival, whereas septal origin was significantly associated with worse RFS.…”

Section: Discussionmentioning

confidence: 99%

“…The Wang system was proposed in 1976, and even though it was based on a group of only 36 patients, it is still considered the most proper since it was specifically designed for NV tumors 16,17 . However, in 1999, Horsman 19 applied the Wang classification to 66 patients with NV‐SCC (cT1 = 55%; cT2 = 35%; cT3 = 11%) and found there was no significant prognostic value.…”

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Pirola,

Di Santo,

Turri‐Zanoni

et al. 2023

The Laryngoscope

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ObjectivesSquamous cell carcinoma of the nasal vestibule (NV‐SCC) is a rare but challenging entity, due to the complex anatomy of the region. Consensus on the best treatment strategy is still lacking, as well as a dedicated staging system. Our aim was to analyze oncological outcomes of surgically treated patients and to investigate possible prognostic factors.MethodsWe performed a retrospective multi‐centric observational study including six Academic Hospitals over a 10‐year period, including only patients who underwent upfront surgery for primary NV‐SCC. Patients were staged according to all currently available staging systems. The Kaplan–Meier method was used to compute overall, disease‐free, and disease‐specific survival. Logistic regression models were used to correlate between survival outcomes and clinical and pathological variables.ResultsSeventy‐one patients with a median follow‐up of 38 months were included in the study. Partial and total rhinectomy were the most commonly performed procedures, respectively, in 49.3% and 25.4% of cases. Neck dissection was performed on 31% of patients, and 45.1% of them underwent adjuvant radiotherapy. Three years overall, disease‐specific and disease‐free survival were, respectively, 86.5%, 90.3%, and 74.2%. None of the currently available staging systems were able to effectively stratify survival outcomes. Factors predicting lower overall survival on multivariate analysis were age (p = 0.021) and perineural invasion (p = 0.059), whereas disease‐free survival was negatively affected by age (p = 0.033) and lymphovascular invasion (p = 0.019).ConclusionCurrently available staging systems cannot stratify prognosis for patients who underwent surgery for NV‐SCC.Level of Evidence4 Laryngoscope, 2023

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Pirola,

Di Santo,

Turri‐Zanoni

et al. 2023

The Laryngoscope

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“…Nasal vestibule cancers staged as T 1 can be treated with RT as a single-modality treatment. 983,984…”

Section: Radiotherapy and Chemotherapymentioning

confidence: 99%

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

Homer,

Winter,

Abbey

et al. 2024

J. Laryngol. Otol.

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Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008–2021)

van de Velde,

Scheurleer,

Braunius

et al. 2024

Head & Neck

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BackgroundSquamous cell carcinoma of the nasal vestibule (SCCNV) is a rare disease, distinctly different in presentation, treatment, and outcome from squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses. However, these are often not analyzed separately.MethodsThe Netherlands Cancer Registry (NCR) and pathology reports from the Dutch Nationwide Pathology Databank (PALGA) were used to identify all newly diagnosed SCCNV cases in the Netherlands between 2008 and 2021.ResultsA total of 763 patients were included. The yearly incidence rate displayed a significant downward trend with an annual percentage change (APC) of −3.9%. The 5‐year overall survival (OS) and disease‐free survival were 69.0% and 77.2%, respectively. The 5‐year relative survival was 77.9% and improved slightly over the inclusion period. OS for patients who were staged cT3 appeared to be worse than those staged cT4a, calling the applicability of the TNM‐classification into question.ConclusionSCC of the nasal vestibule is rare, with declining incidence rates. Introducing a specific topography code for SCCNV is recommended to enhance registration accuracy. The TNM classification seems poorly applicable to SCCNV, suggesting the need to explore alternative staging methods.

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Nasal vestibule squamous cell carcinoma: a population-based cohort study from DAHANCA

Cited by 12 publications

References 25 publications

Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Squamous Cell Carcinoma of the Nasal Vestibule: A Multi‐Centric Observational Cohort Study

Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition

Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008–2021)

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