NASH and Systemic Complications: From Basic to Clinical Research

Baumgartner, Sabine; Shiri-Sverdlov, Ronit

doi:10.3390/biomedicines9121913

Biomedicines

2021

DOI: 10.3390/biomedicines9121913

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NASH and Systemic Complications: From Basic to Clinical Research

Sabine Baumgartner

Ronit Shiri-Sverdlov

Abstract: Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). [...]

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2023

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Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH

Wu²,

Li³

et al. 2023

Inflamm. Res.

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The role of macrophages in the pathogenesis of nonalcoholic steatohepatitis (NASH) is complex and unclear. Here, single-cell RNA sequencing was performed on nonparenchymal cells isolated from NASH and control mice. Two main single macrophage subsets were identi ed that exhibited a signi cant change in cell percentage when NASH occurred: resident Kupffer cells (KCs; Cluster 2) and lipidassociated macrophages (LAMs; Cluster 13). Nearly 93% of single-LAMs in Cluster 13 speci cally expressed Cx3cr1, and an increase in Cx3crl + single-LAMs was speculated to play a proin ammatory role in NASH. Nearly 82% of resident single KCs in Cluster 2 speci cally expressed Cd163, and an inhibited subgroup of Cd163 + resident single-KCs was suggested to have a protective effect in NASH. Similar to Cd163, Vsig4 was both enriched in and speci c to Cluster 2. The percentage of Vsig4 + -KCs was signi cantly decreased in NASH in vivo and in vitro. Hepatocytes and hepatic stellate cells produced less lipid droplet accumulation, proin ammatory protein (TNF-α) and pro brotic protein (α-SMA) in response to coculture with Vsig4 + -KCs than in those cocultured with lipotoxic KCs. Therefore, a subgroup of Vsig4 + resident single-KCs was shown to improve hepatic in ammation and brosis in NASH.

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Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH

Wu²,

Li³

et al. 2023

Inflamm. Res.

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A Meta-analysis on Associated Risk of Mortality in Nonalcoholic Fatty Liver Disease

Ng²,

Yong³

et al. 2023

Endocrine Practice

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NASH and Systemic Complications: From Basic to Clinical Research

Abstract: Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). [...]

Cited by 2 publications

References 12 publications

Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH

Vsig4+ resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH

A Meta-analysis on Associated Risk of Mortality in Nonalcoholic Fatty Liver Disease

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