In view of the difficulties in optimal dispatch caused by diverse energy and various types of equipment in the regional integrated energy system(RIES), this paper established a generalized energy storage model by extracting the flexibility characteristics of cooling, heat, and electrical load based on abstract equivalence. Instead of reducing the accuracy of regulation, this modeling method can greatly simplify the information interaction between the energy dispatching center and energy consumers, thus cutting down the time of collaborative analysis calculations. With the scheduling characteristics of multiple types of flexible loads in day-ahead and intra-day time scales considered comprehensively, a multi-time-scale optimization scheduling model of RIES is established, which takes into account the economy of system operation and the demand response. The simulation results show that the proposed optimization model can fully tap the loadside scheduling potential, along with effectively reducing the computational complexity. Through the coordination of resources with different characteristics, the pressure of balancing energy supply and demand can be relieved, and the operating cost of the system can be minimized. INDEX TERMS Regional integrated energy system (RIES), generalized energy storage model, multi-timescale, optimal dispatch