NASH: From liver diseases to metabolic disorders and back to clinical hepatology

Marchesini, Giulio; Forlani, Gabriele

doi:10.1053/jhep.2002.31551

Cited by 140 publications

(96 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the non Nash diabetic insulin resistance was found to be in form of both acanthosis and skin tags. Almost similar findings were reported by Marchesini G et al [6] Similarly in the laboratory tests, 100 percent diabetics people with NASH in our group were found to have elevated levels of triglyceride , LDL and low HDL levels, and could further indicate insulin resistance. These were comparable to studies by Fan J-G et al who had established the strong association between impaired adipose function and abnormal hepatic lipid partitioning leading to spectrum of NAFLD.…”

Section: Discussionsupporting

confidence: 92%

“…Depending on the criteria set for defining abnormal aminotransferase value in studies such as the Third National Health and Nutritional Examination Survey (NHANES III), the incidence of NAFLD/NASH is between 3 and 23% of the adult population. More recent studies depict a dramatic increase in both the prevalence and severity of NASH in patients with type 2 diabetes [3,6,9,[15][16][17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinico-Pathological Profile of NAFLD in Type 2 Diabetes Mellitus

KP¹

2017

JMSCR

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Clinico-Pathological Profile of NAFLD in Type 2 Diabetes Mellitus

KP¹

2017

JMSCR

View full text Add to dashboard Cite

“…The liver biopsy specimen size was calculated for a minimal and maximal average amount of tissue as previously described. 6 The minimal sample size is biased toward underestimating the amount of tissue, and the maximal sample size overestimated the specimen sample.…”

Section: Methodsmentioning

confidence: 99%

“…4 Nonalcoholic fatty liver disease (NAFLD) constitutes a spectrum of liver injuries associated with obesity and insulin resistance. 5,6 It encompasses steatosis (fatty liver [FL]) with and without inflammation; steatosis and portal fibrosis without zone 3 liver injuries (isolated portal fibrosis [IPF]), and nonalcoholic steatohepatitis (NASH). NASH is defined by zone 3 hepatocellular injury (ballooning degeneration, apoptosis, or Mallory bodies) or perivenular/pericellular fibrosis.…”

mentioning

confidence: 99%

Spectrum of NAFLD and Diagnostic Implications of the Proposed New Normal Range for Serum ALT in Obese Women *

et al. 2005

View full text Add to dashboard Cite

The upper limit of normal for ALT activity has been recommended to be lowered to <30 U/L in men and <19 U/L in women. These changes have been suggested to be diagnostically useful in subjects with nonalcoholic fatty liver disease (NAFLD). Our aim was to investigate the prevalence and spectrum of NAFLD with regard to the new ALT guidelines in 233 women with class II/III obesity. We compared our prior reference range for ALT (ULN < 30 U/L in women) with the new standard. Our study demonstrates that only 86 patients O besity is a major health issue in the United States that is associated with increased morbidity and mortality. 1 The prevalence of obesity (body mass index [BMI] Ն 30 kg/m 2 ) in the United States is 31%, and the prevalence of morbid obesity (BMI Ն 40 kg/m 2 ) is even growing at a greater rate than obesity. 2 The degree of obesity is further subdivided into class I (BMI Ն 30-34.9 kg/m 2 ), class II (BMI 35-39.9 kg/m 2 ), and class III (BMI Ն40 kg/m 2 ). 3 Individuals with class II obesity that is associated with medical comorbidities or class III obesity alone are considered suitable candidates for gastric bypass surgery. 4

show abstract

“…Nonalcoholic fatty liver disease (NAFLD), characterized by elevated alanine-aminotransferase (ALT), and gammaglutamyltransferase (GGT) is now regarded as the hepatic manifestation of the insulin resistance syndrome. 1 Prospective studies have demonstrated that increasing levels of ALT and GGT within the normal range predict incident type 2 diabetes and the metabolic syndrome even when controlling for known risk factors (for example, Sattar et al 2 and Lee et al 3 ). ALT is the enzyme most closely correlated with liver fat accumulation, 4 and therefore the enzyme most commonly used as a biomarker of NAFLD in large epidemiological studies in which more accurate diagnostic methods (such as liver scans and/or biopsy) are not feasible.…”

mentioning

confidence: 99%