Nasolacrimal relapse of nasopharyngeal carcinoma

Sia, K J; Tang, Ing Ping; Kong, C K L; Tan, Tee Yong

doi:10.1017/s0022215112001272

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Among few other reported cases of NPC recurrence involving the nasolacrimal duct and lacrimal sac, there have often been accompanying symptoms related to tearing, including epiphora and bloody tears, resembling a lacrimal sac tumour. [5][6][7] These symptoms may be due to obstruction of the nasolacrimal duct and precede the occurrence of medial orbital mass. Prompt investigation such as early progress PET-CT or EBV DNA titre screening may help early detection of tumour progression.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma Recurrence with Orbital Metastasis through the Nasolacrimal Duct: Uncommon Presentation of a Common Phenomenon

Ng¹,

Luk²,

Ngai

2020

Hong Kong Journal of Radiology

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Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma Recurrence with Orbital Metastasis through the Nasolacrimal Duct: Uncommon Presentation of a Common Phenomenon

Ng¹,

Luk²,

Ngai

2020

Hong Kong Journal of Radiology

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Carcinomas of the lacrimal drainage system

Ramberg

Toft

Heegaard

2020

Survey of Ophthalmology

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Lymphoepithelial Carcinoma of the Nasolacrimal Duct: Clinical, Radiologic, and Immunopathologic Features

Stagner¹,

Rubin²

2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Undifferentiated lymphoepithelial carcinoma (exhibiting both begin lymphoid and malignant epithelial components) most commonly arises in the head and neck, especially in the nasopharynx. It may also be encountered in various ocular adnexal sites, including the nasolacrimal duct. A 63-year-old woman developed a swelling in the region of the right lacrimal sac accompanied by epiphora. CT scanning revealed an enlargement of the nasolacrimal duct from the lacrimal sac to the inferior nasal meatus. A biopsy during dacryocystorhinostomy for symptomatic epiphora revealed hypercellular sheets of small lymphocytes which were interpreted as evidence for a chronic dacryocystitis. Two years later the subtotally excised lesion had substantially grown in size. Repeat CT scans demonstrated an inferonasal anterior orbital mass with further enlargement of the nasolacrimal duct with a solid mass in its lumen, and bone erosion. The biopsy combined a rich background of lymphocytes within which were clusters of undifferentiated carcinoma cells that were cytokeratin and p63 positive. Critical review of the earlier biopsy led to the detection of the same cells, but in smaller numbers, that had been overlooked. An awareness of the possibility of lymphoepithelial carcinoma of the lacrimal sac/duct should improve diagnostic accuracy with the aid of immunohistochemistry. Radiation therapy is often successful in managing this highly sensitive malignant tumor.

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Nasolacrimal relapse of nasopharyngeal carcinoma

Abstract: More targeted radiotherapy should be delivered to prevent under-treatment of nasopharyngeal carcinoma. Nasolacrimal relapse of nasopharyngeal carcinoma is an advanced disease with a poor prognosis.

Cited by 6 publications

References 6 publications

Nasopharyngeal Carcinoma Recurrence with Orbital Metastasis through the Nasolacrimal Duct: Uncommon Presentation of a Common Phenomenon

Nasopharyngeal Carcinoma Recurrence with Orbital Metastasis through the Nasolacrimal Duct: Uncommon Presentation of a Common Phenomenon

Carcinomas of the lacrimal drainage system

Lymphoepithelial Carcinoma of the Nasolacrimal Duct: Clinical, Radiologic, and Immunopathologic Features

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