Nasopharyngeal adenoid cystic carcinoma, suggestion of therapeutic innovations: A case report and review of literature

Tatari, Mohamed Moutaa; Anajar, Said; Hassnaoui, Jawad; Lahjaouj, Meryem; Salama, Khadija; Rouadi, Sami; Abada, R.; Roubal, M.; Mahtar, M.

doi:10.1016/j.amsu.2018.04.004

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…At the initial treatment, a negative surgical margin should be obtained. A few studies have shown that radiotherapy might be effective in achieving local control (2,25), yet chemotherapy is ineffective for the management of secondary ACC in most cases (16).…”

Section: Discussionmentioning

confidence: 99%

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Zheng¹,

He²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Background: Adenoid cystic carcinoma (ACC) is a relatively indolent cancer, for which the major cause of death is distant metastases. The median survival time of patients with distant metastases of ACC is approximately 20 months. Although the liver is not the most common site of secondary ACC, effective treatment of liver metastases could improve patient survival. This study explored the clinical features and treatment of liver metastases of ACC in one centre and performed a literature review. Methods: This is a retrospective cohort study. The records of 25 ACC patients with liver metastases in our hospital from January 2000 to September 2018 and 13 case reports (from 2000 to 2018) from PubMed published in English were reviewed together. Survival curves were estimated by the Kaplan-Meier method. Multivariate cox regression analysis was used to identify risk factors for overall survival (OS). Results: Patients with liver metastases of ACC had a poor prognosis. The median survival time of patients with ACC liver metastases was 14 months (4-26 months), and the 1-, 2-, and 3-year survival rates were 55.8%, 28.5%, and 15.2%, respectively. Isolated liver metastases were more likely to benefit from local treatment, such as surgery and radiofrequency ablation (RFA), than multifocal metastases. The prognosis was worse for patients who received systemic treatment for multifocal liver metastases than for those who received other treatment. Synchronous liver metastases were the predictive factor for OS both in univariate and multivariate analysis. Conclusions: Local treatment, such as surgical resection or RFA, may prolong the survival time of ACC patients with liver metastases. The definition of resectability for liver metastases needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Zheng¹,

He²,

Wu³

et al. 2020

Transl Cancer Res TCR

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“…Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare tumor that represents approximately 1% of all carcinomas of the head and neck. NACC tends to be locally aggressive, demonstrate perineural invasion and appears ominous prognosis [7][8][9][10]. Except the type of nasopharyngeal carcinoma, overall patients with a nasopharyngeal neoplasm frequently present with at least four symptoms including nasal symptoms (epistaxis, nasal obstruction), neck masses, otological symptoms [tinnitus, deafness] and cranial nerve palsies.…”

Section: Introductionmentioning

confidence: 99%

Persistent otitis media with effusion - an unusual type of nasopharyngeal adenocarcinoma

Zarachi¹,

Evangelou²,

Liontos³

et al. 2021

Int. J. Sci. Res. Arch.

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We present the case of a 41-year-old male patient that examined in the outpatient ENT Department of our hospital, reported a persistent otitis media for about six months. Despite medical therapy, his symptom did not improve. The suspicious of a nasopharyngeal mass was raised and the rhino endoscopy revealed a mucosal projection in the left fossa of the Rosenmuller. Computed tomography (CT) of temporal bone pneumatization showed a left mastoid cell occupation and a small projection in the left fossa of the Rosenmuller. The histological examination result of a biopsy of the lession that prepared under local anesthesia, revealed nasopharyngeal adenoid cystic carcinoma. Magnetic resonance imaging indicated the extent of the tumor. The positron emission tomography/computed tomography (PET/CT) scan staged the patient and concluded the diagnosis. The patient underwent both surgery and radiotherapy and addressed oncologists and radiotherapists for further treatment. The patient was diagnosed with lung and kidney metastasis. Adenoid cystic carcinoma is a rare type of adenocarcinoma with ominous prognosis. We always have to raise the suspicious of nasopharyngeal carcinoma, in patients with persistent otological symptoms, that do not improve despite therapy.

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A Rare Nasopharyngeal Adenoid Cystic Carcinoma: Case Report and Literature Review

et al. 2023

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Unusual clinical course Background:Adenoid cystic carcinoma (ACC) is a malignant tumor that involves the salivary glands and is rarely seen in the nasopharynx. It is characterized by pain, a high rate of recurrence, and poor survival rate and poor prognosis as it tends to invade the perineurium. Due to the ambiguity of patient presentations, most patients present at a late stage, at which point metastasis has already occurred. Case Report:The patient in this case report was an otherwise healthy 56-year-old male smoker who presented to the clinic in March 2022 complaining of nasal obstruction, mouth breathing, recurrent epistaxis, headache, and facial pain. He reported significant weight loss in the past 6 months. The nasal scope showed nasopharyngeal fullness and biopsy-confirmed ACC exhibiting tubular, solid, and focal cribriform growth patterns. Further work-up showed an advanced form of nasopharyngeal ACC with intracranial extension and lung metastasis. The patient received concurrent radiotherapy and chemotherapy. After 6 months, the patient reported an improvement in the pain, and repeated images showed regression of the tumor size. Conclusions:ACC is a malignant disease that is rarely seen in the nasopharynx. Currently, the most commonly agreed upon management for resectable ACCs in the literature is through surgical resection with adjuvant radiotherapy. However, most of the reported cases received radiation and chemotherapy due to the difficulty and risk of radical surgical excision of nasopharyngeal malignant tumors. Patients should be followed up to rule out any local recurrence or distant metastasis.

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Nasopharyngeal adenoid cystic carcinoma, suggestion of therapeutic innovations: A case report and review of literature

Cited by 5 publications

References 13 publications

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Possible local treatment for liver metastases of adenoid cystic carcinoma (ACC): single-centre experience and literature review

Persistent otitis media with effusion - an unusual type of nasopharyngeal adenocarcinoma

A Rare Nasopharyngeal Adenoid Cystic Carcinoma: Case Report and Literature Review

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