Nasopharyngeal angiofibroma in an elderly woman

Patrocı́nio, José Antônio; Patrocı́nio, Lucas Gomes; Borba, Bruno Henrique Carrijo; Bonatti, Bruno De Santi; Guimarães, Aparecida H.B.

doi:10.1016/j.amjoto.2004.08.012

Cited by 46 publications

(30 citation statements)

References 13 publications

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“…2 A few cases have been reported in men over 25 years and in female teenagers. [3][4][5] It is thought that the anatomical origin of this tumor is the postero/lateral wall of the nasal cavity, close to the superior border of the sphenopalatine foramen. This tumor starts to grow on the submucosa of the floor of the nasopharynx, reaching the nasal septum and the posterior space of the nose, thereby causing a mass effect that may lead to airway obstruction.…”

Section: Introductionmentioning

confidence: 99%

Experiência de sete anos em pacientes com angiofibroma nasofaríngeo juvenil

Gaillard¹,

Anastácio²,

Piatto³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Juveni le nasopharyngeal angiofibroma (JNA) is a rare tumor in adolescent males. It originates in the nasopharynx. Aim: to present the experience of JNA management at an Otorhinolaryngology Service between 2001 and 2008. Materials and Methods: Demographical data, clinical presentation, investigations as well as the treatment of sixteen JNA patients were reviewed and collected from medical records from the ORL Service. Design: Cross-sectional, retrospective and descriptive study. Results: All JNA patients were male. The average age at diagnosis was 16.8 years (range 9-23 years). More than 56% of the patients were classified as Fisch II. Preoperative embolization was carried out in ten (62.5%) patients. All 16 patients were submitted to primary surgical resection. Two patients (66.7%) who didn't receive preoperative embolization required intraoperative blood transfusion. The overall recurrence rate was 43.75% and the cure rate was 93.75%. Conclusion: Preoperative embolization minimizes intraoperative blood loss. The recurrence rate was related to advanced tumoral stage at diagnostic and the lack of preoperative embolization. Surgery combined with preoperative embolization is the major treatment for JNA. All the patients should undergo preoperative imaging studies, especially CT, to assist in surgical planning and follow-up.

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Section: Introductionmentioning

confidence: 99%

Experiência de sete anos em pacientes com angiofibroma nasofaríngeo juvenil

Gaillard¹,

Anastácio²,

Piatto³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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“…[6] Juvenil nazofarengeal anjiofibromun etyopatogenezini açıklamak için farklı teoriler ileri sürülmüştür. [7] Bu teorileri dört ana kategoride toplamak mümkündür;…”

Section: Discussionunclassified

“…Buna rağ-men literatürde bildirilmiş kadın olgular da bulunmaktadır. [6][7][8][9][10] Bizim çalışmamızda da bir kadın hasta yer almaktadır. Kadın hastalarda JNA tanısı histopatolojik olarak doğrulandığın-da seks kromozom anomalileri araştırılmalıdır.…”

Section: Discussionunclassified

“…Bazı yazarlar fenotipik olarak kadın olan bu hastaların 46,XY genotipe sahip erkek psödo-hermafroditizm sendromu ile ilişkili olduğuna inanmaktadır. [7] Kromozom anomalisi bulunmayan hastalarda ise menopoz ve buna bağlı hormonal değişiklikler araştırılmalıdır. Östrojen hipofiz bezinden trofik hormonların salgılan-masını baskılayarak testesteron ve ürünlerinin salgılanmasını azaltmaktadır.…”

Section: Discussionunclassified

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A juvenile nasopharyngeal angiofibroma: our 10-year experience in a tertiary centre

Şahin

Çomoğlu²,

Sönmez³

et al. 2016

Kulak Burun Bogaz Ihtis Derg

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ÖZAmaç: Bu çalışmada jüvenil nazofarengeal anjiofibrom nedeniyle ameliyat edilen hastaların demografik özellikleri, tümör evresi, cerrahi yöntem ve nüks oranları değerlendirildi. Hastalar ve Yöntemler: Bu retrospektif çalışmaya Mart 2006-Temmuz 2015 tarihleri arasında İstanbul Üniversitesi, İstanbul TıpFakültesi Kulak Burun Boğaz Hastalıkları kliniğinde ameliyat edilen 45 hasta (44 erkek, 1 kadın; ort. yaş 21 yıl; dağılım 9-55 yıl) dahil edildi. Hastalar yaş, cinsiyet, başvuru semptomu, tümörün evresi, uygulanan cerrahi yöntem, ameliyat öncesi embolizasyon, ameliyat sırası kan transfüzyonu, komplikasyonlar ve nüks varlığına göre sınıflandırıldı. Bulgular:En sık başvuru semptomu burun kanaması (%78) ve burun tıkanıklığı (%73) idi. Hastaların tamamına ameliyat öncesi anjiyografi yapıldı ve uygun olan hastalara (%69) embolizasyon uygulandı. Otuz bir hastada transnazal endoskopik yaklaşım, altı hastada midfasiyal degloving ve üç hastada lateral rinotomi yaklaşımı uygulandı. Genel nüks oranı %31 (n=14) idi. Sonuç:Ameliyat sonrası nüks riskini belirleyen en önemli faktör, tümörün ameliyat öncesi evresidir. Ameliyat öncesi embolizasyon, ameliyat sırası kanama miktarını azaltmaktadır. Endoskopik transnazal yaklaşım komplikasyon oranını ve hastanede yatış süresini kısaltmaktadır.Anahtar Sözcükler: Embolizasyon; endoskopik yaklaşım; jüvenil nazofarengeal anjiofibrom; minimal invaziv cerrahi; sonuç. ABSTRACT Objectives:This study aims to evaluate the demographic characteristics, tumor stage, surgical treatment and recurrence rate among patients operated with a juvenile nasopharyngeal angiofibroma. Patients and Methods:This retrospective study included 45 patients (44 males, 1 female; mean age 21 years, range 9 to 55 years) who underwent surgery at Istanbul University, Istanbul Medical Faculty, Department of Otorhinolaryngology clinic between March 2006 and July 2015. The patients were classified according to age, sex, presenting symptom, tumor stage, surgical procedure applied, preoperative embolization, perioperative blood transfusion, complications, and the presence of recurrence. Results:The most common presenting symptoms were epistaxis (78%) and nasal obstruction (73%). Preoperative angiography was performed on all patients and embolization was applied in eligible patients (69%). Transnasal endoscopic approach in 31 patients, midfacial degloving in six patients, and lateral rhinotomy approach in three patients were applied. The overall recurrence rate was 31% (n=14). Conclusion:The most important factor in determining the risk of postoperative recurrence is the preoperative tumor stage. Preoperative embolization reduces the amount of perioperative bleeding. Endoscopic transnasal approach decreases the rate of complications and length of hospitalization.

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“…Further, the association of NAF with familial adenomatous polyposis, in which the prevalence of NAF is 25 times more common than in age-matched controls [15], has not been confirmed in this case series. We consider that NAF occurs exclusively in males, and previous reports in females probably do not represent this tumor, or at least, documentation is not convincing [16][17][18][19]. In 1965, Apostol and Frazell [20] reported 40 cases of NAF in male patients, and suggested that if this diagnosis is confirmed in a female, sex chromosome studies must be performed, to investigate for androgen insensitivity syndrome (formerly testicular feminization) of a phenotypic female but genetic male [18,20].…”

Section: Discussionmentioning

confidence: 99%