Nasopharyngeal Carcinoma in Saudi Arabia: Selected Clinical and Epidemiological Aspects

Clubb, Bryce; Quick, Cedric A.; Amer, Magid H.; Ali, Mohammed Ashraf; Greer, William; Vol, Edward B. De; Mahboubi, Ezzat; El-Senoussi, Mohamed; Schultz, Henrik; Laramore, George E.; El‐Akkad, Salah

doi:10.5144/0256-4947.1990.171

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…16 The most commonly affected site was the nasopharynx, followed by the tongue and buccal mucosa intra-orally, a result comparable to figures reported earlier. 7,17,18 In contrast, in Connecticut, USA, the most commonly affected site was the minor salivary gland, whereas in Indiana, the tongue and floor of the mouth were most predominantly involved. 11,19 The variation in site is probably due to differences in risk factors among the population.…”

Section: Discussionmentioning

confidence: 89%

Oral and Upper Aero-Digestive Tract Malignancy: A Review of a Five-Year Experience

Al-Mobeerik

1998

Ann Saudi Med

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Section: Discussionmentioning

confidence: 89%

Oral and Upper Aero-Digestive Tract Malignancy: A Review of a Five-Year Experience

Al-Mobeerik

1998

Ann Saudi Med

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“…NPC is one of the most common malignancy of the head and neck accounting for 30%–33% of all tumors in this region. [ 2 6 ] It is more prevalent in the Asian and African population. NPC represents around 6% of all cancers reported annually in our population.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] In Saudi Arabia, NPC represented 30% of all the reported head-and-neck tumors, with an age-standardized incidence rate of 1.5 per 100,000 population in male and 0.5 in female. [ 2 ] Neck mass was the most common complaint of these patient, and cranial nerve palsy being the 5 th most common complaint. [ 2 ] In our literature review, we only found three case series that reported ophthalmic manifestations of NPC tumors before or in association with NPC initial presentation.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] Neck mass was the most common complaint of these patient, and cranial nerve palsy being the 5 th most common complaint. [ 2 ] In our literature review, we only found three case series that reported ophthalmic manifestations of NPC tumors before or in association with NPC initial presentation. [ 3 4 5 ] To the best of our knowledge, there were no local similar reports describing ophthalmic complaints as an initial presentation of NPC in our region.…”

Section: Introductionmentioning

confidence: 99%

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Nasopharyngeal carcinoma (NPC) in the ophthalmic practice

Alkatan

Alrashed

Alarfaj

et al. 2021

Saudi Journal of Ophthalmology

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PURPOSE: Nasopharyngeal carcinoma (NPC) is an aggressive malignant tumor that arises from the nasopharyngeal epithelial lining. Most patients with NPC present with a neck mass or cranial nerve palsy. It is infrequent for patients with NPC to present to an ophthalmologist initially with ophthalmic complaints and absence of prior diagnosis of NPC. We are reporting a series of six NPC cases that presented solely with ophthalmic complaints, to attract the attention of ophthalmologist to such a serious neoplasm. METHODS: A retrospective observational study of all consecutive patients diagnosed with NPC based on their initial ophthalmic presentation with no prior diagnosis of this neoplasm. Patients presented for the first time to two tertiary eye hospitals. Data were collected by the chart review for demographics, clinical presentation, radiological imaging, treatment regimen, and follow-up. Histopathological review of their tissue specimens was conducted by two pathologists. RESULTS: We had six patients who presented for the first time to our ophthalmic service complaining mostly of limitation of extraocular muscle motility with or without diplopia (4/6), orbital or facial pain (2/6), and disturbance in vision (2/6). The age ranged from 35 to 92 years with a mean of 58 years. A male predominance was observed with male-to-female ratio of 5:1. The cases are described along with their imaging and histopathological findings. Relevant literature review was also presented. Most of our patients (5/6) received combination of radiotherapy and chemotherapy. One patient refused treatment and 2 eventually passed away after 7 months. CONCLUSION: Ophthalmologists may play a major role in diagnosing such patients accurately and referring them for early management and better prognosis.

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“…The nasopharyngeal cancer in this study accounts for 8.3% of head and neck cancer; others have found the incidence to be 26% and 30% of head and neck cancer. 2,14 This may be related to a number of factors such as viral infection (Epstein-Barr virus), food habits such as salty fish, preservative materials and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Head and Neck Cancer in a Referral Center in Asir Region

Alghamdi

Malatani

Kameswaran

et al. 1994

Annals of Saudi Medicine

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This study looks at the incidence of head and neck cancer in the Southwest Region of the Kingdom of Saudi Arabia (Asir Region). There were a total of 204 newly diagnosed patients seen at Asir Central Hospital between 1987 and 1992; 113 males and 91 females. All were Saudi patients. Frequency at various sites with reference to sex and age was determined and comparison with local and international published reports was made. To the best of our knowledge, this is the first paper in the Kingdom to look at head and neck cancer as a distinct entity. In this study, skin cancer was the most common among males followed by oral and pharyngeal cancers. Among females, thyroid cancer was the most common followed by skin and oral cancers. Some preventive measures are discussed. Ann Saudi Med 1994;14(5):383-386. Two studies reviewed from different parts of the Kingdom that looked at the whole body cancers estimated the incidence of head and neck cancers to be 18.4% and 12.2%. 2,3 In another study from the Eastern Province, the number was 4.5% excluding skin and thyroid cancers. 4 The authors of the first two papers stated that the head and neck cancers are more common in this country compared to western countries. This assertion is borne out in our study. This is a hospital-based study of the pattern of head and neck cancers presenting to a 576 bed tertiary care facility. This represents 21.4% of total hospital beds available in the region (2687). Material and MethodsThis is a retrospective study based on data collected from the charts of 204 patients of all age groups, diagnosed and in most instances treated at Asir Central Hospital over a period of six years (January 1987 to December 1992). This represents 0.79% of the total admissions (52,768) during the study period. Carcinomas in situ were excluded. Non-Saudi patients were also excluded. Metastasis from sites other than the head and neck region were not included. Only patients with confirmed histological diagnosis were included in this study. The data obtained was compared with data previously reported from other institutions regarding relative frequency, the rank orders, and histological types. ResultsTwo hundred and four patients form the basis of this study; 55.3% were males. Only Saudi patients were included in this study. Their ages ranged from three to 91 years with an average age of 57 for males and 52 for females. Cancers of the skin, thyroid, oral cavity, pharynx and lymphoreticular system were the most commonly encountered. Figure 1 shows a map of Saudi Arabia showing the location of Asir Region. Figure 2 shows the ages and sex distribution of head and neck cancers. The total population of the Asir Region is approximately 1,500,000 according to the last census done six months ago and the number of all cases of cancer in Asir at the time of this study were 1322. Fifteen and four-tenths percent were head and neck cancers reducing to 9.6% when thyroid and skin cancers are excluded. The incidence per 100,000/year is approximately 16.6 for all body cancers and 2.72 ...

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Nasopharyngeal Carcinoma in Saudi Arabia: Selected Clinical and Epidemiological Aspects

Cited by 5 publications

References 7 publications

Oral and Upper Aero-Digestive Tract Malignancy: A Review of a Five-Year Experience

Oral and Upper Aero-Digestive Tract Malignancy: A Review of a Five-Year Experience

Nasopharyngeal carcinoma (NPC) in the ophthalmic practice

Head and Neck Cancer in a Referral Center in Asir Region

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