Nasopharyngeal Carcinoma, with Emphasis on its Relationship to Epstein-Barr Virus

Vasef, Mohammad A.; Ferlito, Alfio; Weiss, Lawrence M.

doi:10.1177/000348949710600416

Cited by 115 publications

(78 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In situ detection of the EBV noncoding transcripts EBER1 and EBER2 in biopsies has been routinely used in clinical diagnosis of NPC. 14,15 Elevated levels of antibodies against latent and lytic EBV proteins have been found among the sera of NPC patients. 16,17 While numerous studies have compared the different profiles of EBV antibodies between NPC and non-NPC individuals, a specific serological test which can be reliably used for NPC screening is still unavailable.…”

mentioning

confidence: 99%

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Zhang

Zong

Shen

et al. 2014

Intl Journal of Cancer

104

View full text Add to dashboard Cite

More than 75% of nasopharyngeal carcinoma (NPC) patients have already developed local or regional spread at diagnosis, which hampers effective treatment and results in a poor prognosis. It is essential to characterize more sensitive and specific biomarkers for screening of high risk individuals and assessment of NPC treatment effectiveness. NPC is an Epstein-Barr virus (EBV) associated tumor in which only a few viral proteins but more than 20 BamHI A rightward transcripts (BART) microRNAs are detected, at abundant levels. We hypothesized that these BART microRNAs may be novel biomarkers for NPC. Systematic analysis of EBV BART microRNA expression profiles in EBV latently infected Mutu I and Mutu III cell lines, EBV-harboring NPC and noncancerous NP cells found that miR-BART3, miR-BART7 and miR-BART13 microRNAs are highly expressed and regularly secreted into the extracellular environment of NPC cells. These BART microRNAs were evaluated for used as potential NPC biomarkers. Analysis of plasma specimens obtained from NPC patients (n 5 89), and healthy (n 5 28) and non-NPC tumor patient controls (n 5 18) found levels of both miR-BART7 and miR-BART13, but not miR-BART3, to be distinctly presence among NPC patients, with elevated levels being particularly apparent among patients with advanced disease. Receiver operating characteristic curve analysis combining miR-BART7 and miR-BART13 levels produces a 90% predictive value for the presence of NPC. Analysis of 41 NPC patients before and after radiotherapy showed that miR-BART7 and miR-BART13, but not miR-BART3, were diminished after treatment. These results indicate that EBV microRNAs, miR-BART7 and miR-BART13, may constitute useful new serological biomarkers for diagnosis of NPC and prediction of treatment efficacy.

show abstract

mentioning

confidence: 99%

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Zhang

Zong

Shen

et al. 2014

Intl Journal of Cancer

104

View full text Add to dashboard Cite

show abstract

“…Non-nasopharyngeal undifferentiated carcinoma is usually associated with EBV in endemic areas such as Southeast Asia, 6,10 but in Western countries and most other areas of the world, almost all of the cases are EBV negative. 11,12,7 Oropharyngeal squamous cell carcinoma is frequently associated with transcriptionally active high-risk human papillomavirus (HPV). HPV-related tumors typically have a distinctive non-keratinizing morphology, [13][14][15] show strong p16 protein expression, 16 and have lower rates of p53 mutation 17 than most other head and neck squamous cell carcinoma.…”

mentioning

confidence: 99%

Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis

2011

View full text Add to dashboard Cite

Undifferentiated carcinoma (undifferentiated carcinoma, nasopharyngeal type, or lymphoepithelial carcinoma) is an uncommon and histologically distinct tumor in the oropharynx, which in Western countries, has been clearly shown not to harbor Epstein Barr virus (EBV). We sought to analyze these tumors for human papillomavirus (HPV) and to examine their clinical outcomes. All cases of oropharyngeal carcinoma diagnosed as 'undifferentiated' or 'lymphoepithelial' were retrieved from the department files at Barnes-Jewish Hospital. After consensus review by all three study pathologists, 16 were found to have diagnostic histological features and to lack distinguishing characteristics of other oropharyngeal cancers. Immunohistochemistry for p16 and p53 and in-situ hybridization for HPV and EBV encoded small RNA were performed. p16-positive but HPV in situ hybridization-negative cases were analyzed by polymerase chain reaction for high-risk HPV types. The results were correlated with pathological findings and clinical follow up. There were 16 patients. The average age was 59.2 years, 14 patients (88%) were smokers, and 13 (81%) had nodal metastases. In all, 14 cases (88%) were p16 positive and 15 (94%) were HPV positive by in situ hybridization and/or polymerase chain reaction. All cases were negative for EBV, and p53 was overexpressed in five (33%), four of which were HPV positive. Disease recurred in only three patients and two of these died with disease at 38 and 136 months, respectively. Three year overall, disease-free, and disease-specific survival rates were 54, 78, and 100%, respectively. In summary, in our patient population, the majority of oropharyngeal undifferentiated carcinomas harbor transcriptionally active HPV but not EBV. Almost all overexpress p16, and few have p53 overexpression. Disease-specific survival is comparable to published rates for other HPV-related oropharyngeal squamous cell carcinoma variants and is better than that of HPV-negative carcinomas.

show abstract

“…Specifically, occupational exposures are particularly prominent for sinonasal cancer, 1,3 and Epstein-Barr (EB) virus infection and salted fish are the most important risk factors for nasopharyngeal cancer. 1,[3][4][5] However, risk factors for sinonasal and nasopharyngeal cancers have rarely been compared simultaneously within the same population. Exploring the similarities and differences between the 2 cancers within the same population has special potential to provide additional information on risk factors and potential interactions between risk factors, anatomic sites and histologic structures.…”

mentioning

confidence: 99%

Case‐control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers

Zhu

Levine

Brann

et al. 2002

Intl Journal of Cancer

View full text Add to dashboard Cite

Sinonasal cancer and nasopharyngeal cancer may share some risk factors because both are located within the upper aerodigestive tract. They may also have different etiological profiles because of anatomic or pathologic differences. However, the similarities and differences in risk factors have rarely been studied within the same population. We assessed the risk factor profiles of sinonasal and nasopharyngeal cancers, using data from a case-control study. The 2 case groups consisted of men aged 31-59 and diagnosed pathologically with sinonasal cancer (n‫)07؍‬ and nasopharyngeal cancer (n‫,)311؍‬ respectively. Controls were men without these cancers and selected from the same areas (n‫.)0191؍‬ Logistic regression analysis showed that smoking was a risk factor for both sinonasal [odds ratio (OR)‫,5.2؍‬ 95% confidence interval (CI) 1.1-5.4] and nasopharyngeal cancer (OR‫,8.1؍‬ 95%CI 1.1-3.0). However, ever use of barbiturates without a prescription (OR‫,9.4؍‬ 95%CI 1.7-13.8), working with or around cutting oils on a job (OR‫,9.1؍‬ 95%CI 1.1-3.1) and ever having had sinus infections (OR‫,3.2؍‬ 95%CI 1.1-4.6) were associated with nasopharyngeal cancer only. Having received blood products other than a transfusion (OR‫,1.9؍‬ 95%CI 2.2-37.4) and exposure to a pesticide containing 2,4,5-T (OR‫,9.5؍‬ 95%CI 1.5-23.7) were related to sinonasal cancer only. When data analyses were confined to squamous cell type, smoking and exposure to chlorophenols were related to squamous cell tumors at both sites. However, use of barbiturates and sinus problems other than infection only increased the risk of nasopharyngeal carcinoma. Our study suggests that except for smoking and chlorophenol exposure, which are associated with both sites, the risk factor profiles may differ between sinonasal and nasopharyngeal cancers. © 2002 Wiley-Liss, Inc. Key words: case-control studies; nasopharyngeal cancer; risk factors; sinonasal cancer; smokingContiguous sites within a system may be prone to the effect of the same risk factors for cancer because of their common exposures. However, the sites within a system usually differ in anatomical or histologic features and therefore may have different susceptibility to different etiological factors, resulting in different risk factor profiles. Sinonasal cancer (malignancies of the sinus or nasal cavities) and nasopharyngeal cancer (malignancies of the nasopharynx) may share some risk factors because both are located within the upper aerodigestive tract. They may also possess different epidemiological and etiological profiles because of anatomic or pathologic differences. It is known that sinonasal cancer occurs more frequently in individuals in their 60s and in some areas in Japan, France, India and South Africa, 1 while nasopharyngeal cancer is more frequent in Southern China and some African tribes and incidence rates reach a peak during adolescence or during ages 45-55. 2,3 Studies in different regions and different populations have identified distinct risk-factor profiles for sinonasal and nasopharyngeal ...

show abstract

Nasopharyngeal Carcinoma, with Emphasis on its Relationship to Epstein-Barr Virus

Cited by 115 publications

References 86 publications

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Circulating Epstein–Barr virus microRNAs miR‐BART7 and miR‐BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment

Undifferentiated carcinoma of the oropharynx: a human papillomavirus-associated tumor with a favorable prognosis

Case‐control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers

Contact Info

Product

Resources

About