Nasopharyngeal Meningococcal Carriage among Children and Adolescents in Turkey in 2018: An Unexpected High Serogroup X Carriage

KIZIL, Mahmut Can; Kılıç, Ömer; Ceyhan, Mehmet; Nepesov, Merve İşeri; Karbuz, Adem; Kurugöl, Zafer; Hacımustafaoğlu, Mustafa; Çelebi, Solmaz; Dinleyici, Ener Çağrı; Çarman, Kürşat Bora; Bayhan, Cihangül; Balliel, Yasemin; Sütçü, Murat; Kuyucu, Necdet; Kondolot, Meda; Kara, Soner Sertan; Demir, Sevliya Öcal; Çay, Ümmühan; Aydın, Zeynep Gökçe Gayretli; Kaya, Mucahit

doi:10.3390/children8100871

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…According to surveillance data, Nm is the most prevalent bacterium responsible for pediatric bacterial meningitis, and MenB was the most common strain in Türkiye between 2005 and 2018, followed by MenW, MenA, and MenY [ 14 ]. Men C has not been reported from IMD surveillance studies or from carriage studies in Türkiye [ 13 , 14 , 15 , 16 ]. There are no meningococcal vaccines in the routine childhood immunization program.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

et al. 2023

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Introduction: While there is a significant amount of information about invasive meningococcal disease (IMD), meningococcal carriage, and meningococcal vaccines in children and adolescents, data in older adults are limited. Studies of meningococcal carriage and transmission modeling can be utilized to predict the spread of IMD and guide prevention and treatment strategies. Our study’s main objective was to assess the prevalece of Neisseria meningitidis (Nm) carriage, serogroup distribution, and associated risk factors among older adults in Türkiye. Methods: Nasopharyngeal samples were collected between December 2022 and January 2023 from a total of 329 older adults (65 years of age and above). The samples were tested via PCR for Nm, and a serogroup (A, B, C, Y, W, X, E, Z, H) analysis of the positive samples was performed. Results: In total, 329 adults over 65 years of age (150 females and 179 males; 69% were 65–75 years old and 31% were 75 years of age and older) were included in the study. Nm carriage was detected in 46 participants (13.9%), and the serogroup distribution was as follows: 2.4% MenY (n = 8), 1.8% MenB (n = 6), 0.2% MenW (n = 2), and 9.4% non-groupable (n = 31). Other serogroups were not detected. Between the meningococcal carriers and the non-carriers, there were no differences between previous vaccination histories (meningococcal, pneumococcal, influenza, and COVID-19), travel history for Hajj and/or Umrah, and the presence of chronic disease. Of the 16 cases positive for the serogroups Y, B, and W, 13 patients were between the ages of 65 and 74 and three patients were over 75 years old, and these three cases represented MenY. Conclusion: In our study, the percentage of meningococcal carriage was found to be 13.9%, the carriage rate for encapsulated strains was 4.8%, and the most common serogroup was MenY. Men Y was also the only serogroup detected in patients over 75 years of age. The MenY serogroup, which is one of the most important causes of IMD (especially in pneumonia cases) in people older than 65 years, was the most frequently carried serogroup in people over 65 years of age in our study. Adequate surveillance and/or a proper carriage study would help to define potential vaccination strategies for older adults.

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Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

et al. 2023

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“…In Turkey, serogroup B and serogroup W are the predominant consecutive serogroups in IMD, and serogroups A, Y, and X have also been reported as causes [ 3 ]. Serogroups W, B, and X are also important causes of nasopharyngeal meningococcal carriage in Turkey [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Intestinal and Nasopharyngeal Microbiota of Children with Meningococcemia in Pediatric Intensive Care Unit: INMACS-PICU Study

et al. 2023

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Microbiota composition might play a role in the pathophysiology and course of sepsis, and understanding its dynamics is of clinical interest. Invasive meningococcal disease (IMD) is an important cause of community-acquired serious infection, and there is no information regarding microbiota composition in children with meningococcemia. In this study, we aimed to evaluate the intestinal and nasopharyngeal microbiota composition of children with IMD. Materials and Methods: In this prospective, multi-center study, 10 children with meningococcemia and 10 age-matched healthy controls were included. Nasopharyngeal and fecal samples were obtained at admission to the intensive care unit and on the tenth day of their hospital stay. The V3 and V4 regions of the 16S rRNA gene were amplified following the 16S Metagenomic Sequencing Library Preparation. Results: Regarding the alpha diversity on the day of admission and on the tenth day at the PICU, the Shannon index was significantly lower in the IMD group compared to the control group (p = 0.002 at admission and p = 0.001, on the tenth day of PICU). A statistical difference in the stool samples was found between the IMD group at Day 0 vs. the controls in the results of the Bray–Curtis and Jaccard analyses (p = 0.005 and p = 0.001, respectively). There were differences in the intestinal microbiota composition between the children with IMD at admission and Day 10 and the healthy controls. Regarding the nasopharyngeal microbiota analysis, in the children with IMD at admission, at the genus level, Neisseria was significantly more abundant compared to the healthy children (p < 0.001). In the children with IMD at Day 10, genera Moraxella and Neisseria were decreased compared to the healthy children. In the children with IMD on Day 0, for paired samples, Moraxella, Neisseria, and Haemophilus were significantly more abundant compared to the children with IMD at Day 10. In the children with IMD at Day 10, the Moraxella and Neisseria genera were decreased, and 20 different genera were more abundant compared to Day 0. Conclusions: We first found alterations in the intestinal and nasopharyngeal microbiota composition in the children with IMD. The infection itself or the other care interventions also caused changes to the microbiota composition during the follow-up period. Understanding the interaction of microbiota with pathogens, e.g., N. meningitidis, could give us the opportunity to understand the disease’s dynamics.

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Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe

Borrow,

Campbell,

Caugant

et al. 2024

Journal of Infection

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Nasopharyngeal Meningococcal Carriage among Children and Adolescents in Turkey in 2018: An Unexpected High Serogroup X Carriage

Cited by 5 publications

References 30 publications

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

Nasopharyngeal Meningococcal Carriage among Older Adults in Türkiye (MeninGOLD Study)

Analysis of Intestinal and Nasopharyngeal Microbiota of Children with Meningococcemia in Pediatric Intensive Care Unit: INMACS-PICU Study

Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe

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