Nasopharyngeal Papillary Adenocarcinoma as a Second Head and Neck Malignancy

Abstract

Nasopharyngeal adenocarcinomas are rare tumours, and include neoplasms arising from the nasopharyngeal surface epithelium as well as those of minor salivary gland origin, each of which is distinct from the other. The former encompasses nasopharyngeal papillary adenocarcinoma (NPAC), also known as low grade NPAC and thyroid-like NPAC, an extremely unusual malignancy bearing histomorphological similarity to papillary thyroid carcinoma, and displaying indolent clinical behaviour. We report the case of a 41-year-old lady who developed NPAC as a second malignancy five-and-a-half years after being diagnosed and treated for a diffuse astrocytoma in the frontal lobe. In addition, we discuss the differential diagnosis, as well as raise certain pathogenetic considerations with regard to this unique neoplasm.

Design of InnoPrimers-Duplex Real-Time PCR for Detection and Treatment Response Prediction of EBV-Associated Nasopharyngeal Carcinoma Circulating Genetic Biomarker

“…NKC constituted about 91.2% (55.9% WHO type III and 35.3% WHO type II), and 5.9% of NPC patients had squamous cell carcinoma (SCC) (WHO type I) in this study, which was comparable to the previous studies, where they reported higher occurrence rates of NKUC followed by NKDC and lower rates of SCC [58,[60][61][62]. One patient was diagnosed as papillary variant, nasopharyngeal adenocarcinomas (NACs), which is a rare tumor accounting for less than 0.5% of nasopharyngeal malignancies and can occur in up to 10% of NPC cases in the endemic areas [63,64]. The vast majority of NPC patients in this study had locally advanced NPC (stage IV and stage III).…”

Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC

“…These features are very similar to thyroid papillary adenocarcinoma. In some previously reported cases, the transition from the normal surface respiratory epithelium to tumor cells was identified, [ 2 , 6 – 8 ] all of which were also observed in the present case.…”

“…[ 23 ] However, the role of adjuvant radiotherapy is not established as these well-differentiated tumors respond poorly to radiation. [ 6 ] In our case, because the surgical margin was negative, and the patient was young, he did not receive adjuvant radiation therapy or chemotherapy. The patient has remained free of local recurrence and distant metastasis during the 3.5-year postoperative follow-up.…”

“…To date, only 42 cases of nasopharyngeal papillary adenocarcinoma have been reported in the literature, including 26 reports in English and 16 in Chinese. [ 2 , 6 – 8 ] No gender predisposition is reported for this tumor. Histologically, this tumor exhibits papillary architecture with fibrovascular cores lined by cuboidal to columnar epithelium, eosinophilic cytoplasm, and round-to-bland oval nuclei of the epithelial cells, overlapping nuclei with optically clear chromatin, and scattered psammoma bodies.…”

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

“…Furthermore, it was suggested that TL-LGNPPA has an excellent prognosis and that local invasion or distant metastasis of TL-LGNPPA was extremely rare. Some studies have reported the local extension of LGNPPA into the sphenoid sinus (28) or parapharyngeal space (29); however, an immunohistochemical study was negative for TTF-1 in these two cases of LGNPPA. TL-LGNPPA might tend to grow more slowly than LGNPPA without the expression of TTF-1, and the frequency of local invasion might differ from that in LGNPPA without the expression of TTF-1.…”