Nation-wide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system

Coler-Reilly, Ariella Lg; Hashimoto, Michiyo; Yagishita, Naoko; Sato, Tomoo; Ando, Hitoshi; Yamauchi, Junji; Araya, Natsumi; Kimura, Miyako; Yamano, Yoshihisa; Takata, Ayako

doi:10.1186/1742-4690-11-s1-p17

Cited by 2 publications

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“…While in the last 15 years, it became clear that HTLV-1infected individuals even without myelopathy had urinary symptoms and erectile dysfunction 22,23 ; no studies have evaluated intestinal complaints in such patients. In patients with HAM / TSP, the frequency of constipation was reported to be greater than 60 % 15,16 . It is known that intestinal dysfunction is common in patients with spinal cord injuries 24 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the occurrence of neurogenic bowel in individuals infected with HTLV-1 has been poorly studied. Constipation appeared the most frequent digestive tract symptom in HTLV-1 patients and two retrospective studies showed that it was present in 67 % and 78.2 % of patients with HAM / TSP 15,16 . These studies did not address the frequency of other bowel symptoms and did not use a seronegative control group to allow a more rigorous comparison.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus

Oliveira

Andrade

Santos

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine the frequency of bowel symptoms in HTLV-1 infected individuals and their correlation with the degree of neurologic disease. Methods: This is a cross-sectional study comparing the frequency of bowel symptoms in HTLV-1-infected individuals * and seronegative donors (controls). Patients answered a questionnaire, the Rome III Criteria was applied, and stool consistency was evaluated by the Bristol Stool Form Scale. The individuals were classified as HTLV-1 carriers, probable HTLV-1 myelopathy and definitive HTLV-1 associated myelopathy or tropical spastic paraparesis (definitive HAM / TSP) **. Results: We studied 72 HTLV-1 infected individuals and 72 controls with equal age and gender distribution. Constipation was the most frequent complaint, occurring in 38 % of HTLV-1 individuals and in 15 % of the controls. In comparison to the seronegative controls, the probability of constipation occurrence was approximately 18 times higher in definitive HAM / TSP patients. Straining, lumpy or hard stools, sensation of anorectal obstruction/blockage, fewer than 3 defecations per week, flatulence, soiling, evacuation pain, and bleeding were also more frequent in the HTLV-1 patients than in the controls. Moreover, bowel symptoms were more frequent in patients with definitive or probable HAM / TSP than in carriers. Conclusions: Bowel symptoms were more frequent in HTLV-1-infected patients than in seronegative controls and the frequency of bowel symptoms correlated with the severity of neurologic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus

Oliveira

Andrade

Santos

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…Factors that affect the health and the quality of life in patients were highlighted at this meeting, such as HIV co-infection and physical inactivity. Nation-wide epidemiological studies with a novel patient registration system in Japan appears to be an important improvement (Coler-Reilly et al ), which is expected to evolve into an international system because of the relatively small number of HAM/TSP patients [ 42 ]. Three abstracts described familial clustering of HAM/TSP patients (Nozuma et al , Coler-Reilly et al , and Alvarez et al .)…”

Section: Introductionmentioning

confidence: 99%

“…Three abstracts described familial clustering of HAM/TSP patients (Nozuma et al , Coler-Reilly et al , and Alvarez et al .) [ 42 - 44 ]. Results from Nozuma et al and Coler-Reilly et al suggested positive clustering and lower age of onset [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada

et al. 2014

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The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26th to June 30th, 2013 and was therefore hosted by a Canadian city for the first time. The major topic of the meeting was human T-lymphotropic viruses (HTLVs) and was covered through distinct oral and poster presentation sessions: clinical research, animal models, immunology, molecular and cellular biology, human endogenous and emerging exogenous retroviruses and virology. In this review, highlights of the meeting are provided by different experts for each of these research areas.

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Nation-wide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system

Abstract: Coler-Reilly et al.: Nationwide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system. Retrovirology 2014 11(Suppl 1):P17.

Cited by 2 publications

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Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus

Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada

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