Background-Because of the health impact of acute myocardial infarction (AMI), substantial resources have been dedicated to improving AMI care and outcomes. Long-term trends in the clinical characteristics, quality of care, and outcomes for AMI over time from the health system perspective in geographically diverse populations are not well known. Methods and Results-The present study included 20 550 Medicare patients aged Ն65 years hospitalized in 4 US states (Alabama, Connecticut, Iowa, Wisconsin) with the confirmed primary discharge diagnosis of AMI in 4 periods: 1992-1993 (nϭ10 292), 1995 (nϭ5566), 1998 -1999 (nϭ2413), and 2000 -2001 (nϭ2279). With the use of standard quality indicator definitions, treatment of ideal candidates with aspirin and -blockers within 24 hours after presentation, -blockers, and angiotensin-converting enzyme inhibitors at discharge was assessed. Multivariable models were constructed to calculate adjusted 1-year mortality.