National Failure of Surgical Staging for T1b Gallbladder Cancer

Vo, Elaine; Curley, Steven A.; Chai, Christy; Massarweh, Nader N.; Cao, Hop S. Tran

doi:10.1245/s10434-018-7064-7

Cited by 26 publications

(24 citation statements)

References 14 publications

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“…Radical cholecystectomy was recommended for T1b GBC by the NCCN guidelines nearly 10 years ago; however, only 50% of T1b patientswith GBC in the USA received radical cholecystectomy. 14 Bergquist et al 26 reported that from 2004 to 2012, only 28.2% of patients with GBC with positive nodal disease received adjuvant chemotherapy in the National Cancer Database of the USA even though this was the recommended treatment in the NCCN guidelines. Knowing the current situation is essential for future improvement; however, no data have been reported on GBC treatment in China.…”

Section: Discussionmentioning

confidence: 99%

“…12 13 In addition, cystic duct cancer is undistinguishable from ECC in most cancer registry studies, which means that this specific subset of patients is likely to be omitted. 14 Moreover, a commonly used coding system for surgery, the Facility Oncology Registry Data System, classifies GBC as ‘all other sites’, making it unlikely to define the extent of surgery and distinguish patients who undergo re-resection after GBC is incidentally found. 15 Regarding regional lymph nodes, the Collaborative Stage (V.0204) system defines coeliac, superior mesenteric and para-aortic lymph nodes as regional nodes, which is not consistent with either the AJCC seventh or AJCC eighth definition.…”

Section: Introductionmentioning

confidence: 99%

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Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study

Ren

Zhang

et al. 2021

BMJ Open

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IntroductionGallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on the clinical characteristics, treatment and prognosis of GBC in the Chinese population.Methods and analysisThe Chinese Research Group of Gallbladder Cancer (CRGGC) study is a multicentre retrospective registry cohort study. Clinically diagnosed patient with GBC will be identified from 1 January 2008 to December, 2019, by reviewing the electronic medical records from 76 tertiary and secondary hospitals across 28 provinces in China. Patients with pathological and radiological diagnoses of malignancy, including cancer in situ, from the gallbladder and cystic duct are eligible, according to the National Comprehensive Cancer Network 2019 guidelines. Patients will be excluded if GBC is the secondary diagnosis in the discharge summary. The demographic characteristics, medical history, physical examination results, surgery information, pathological data, laboratory examination results and radiology reports will be collected in a standardised case report form. By May 2021, approximately 6000 patient with GBC will be included. The clinical follow-up data will be updated until 5 years after the last admission for GBC of each patient. The study aimed (1) to depict the clinical characteristics, including demographics, pathology, treatment and prognosis of patient with GBC in China; (2) to evaluate the adherence to clinical guidelines of GBC and (3) to improve clinical practice for diagnosing and treating GBC and provide references for policy-makers.Ethics and disseminationThe protocol of the CRGGC has been approved by the Committee for Ethics of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (SHEC-C-2019–085). All results of this study will be published in peer-reviewed journals and presented at relevant conferences.Trial registration numberNCT04140552, Pre-results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study

Ren

Zhang

et al. 2021

BMJ Open

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“…This may be because only the number of total lymph nodes dissected was considered. Many studies have shown that the rate of positive lymph nodes is closely related to the prognosis of patients with malignant tumors, such as GBC [ 24 , 26 – 29 , 32 ]. The AJCC recommends the removal of at least 12 lymph nodes to be sufficient for accurate tumor staging [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our results, the AJCC T stage and AJCC M stage were considered to be independent prognostic factors. Lymph node metastasis is the most important prognostic factor, and many studies show that only adequate lymph node dissection will give patients a better prognosis [24][25][26][27]. In our research, we did not use traditional AJCC lymph node staging.…”

Section: Biomed Research Internationalmentioning

confidence: 98%

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Prognostic Evaluation for Patients over 45 Years Old with Gallbladder Adenocarcinoma Resection: A SEER-Based Nomogram Analysis

Song

2020

BioMed Research International

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Gallbladder adenocarcinoma is the main histopathological type of gallbladder cancer (GBC), so it is particularly important to understand its biological characteristics. Due to the low incidence of this type of cancer, there are few studies with large sample sizes. The log of positive lymph nodes (LODDS) has been evaluated by many scholars as a lymph node stage that may play a better role than the 8th edition of the American Joint Committee on Cancer (AJCC) lymph node staging system in many cancers. However, the effect of LODDS has not been proven in gallbladder adenocarcinoma. Our research aimed to identify independent prognostic factors that are closely related to overall survival (OS) in patients with gallbladder adenocarcinoma over 45 years of age using data from the Surveillance, Epidemiology and, End Results (SEER) database. All patients were randomly divided into a modeling cohort and an internal validation cohort. Seven independent prognostic factors associated with OS—age, marital status, grade, tumor size, AJCC 8th edition T stage and M stage, and LODDS—were used to build a nomogram to predict 1-, 3-, and 5-year survival. The C-index of our nomogram was 0.735 (95% CI, 0.716 to 0.754), and together with the calibration curve and ROC curve validation, the results confirmed the prediction effect of our nomogram. We believe that our nomogram will be an accurate and convenient method for patient prognosis assessment in the future.

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Essential updates 2019/2020: Surgical treatment of gallbladder cancer

Matsuyama

Yabusita

Homma

et al. 2021

Annals of Gastroent Surgery

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Gallbladder cancer is a biliary tract cancer that originates in the gallbladder and cystic ducts and is recognized worldwide as a refractory cancer with early involvement of the surrounding area because of its anatomical characteristics. Although the number of cases is increasing steadily worldwide, the frequency of this disease remains low, making it difficult to plan large‐scale clinical studies, and there is still much discussion about the indications for surgical resection and the introduction of multidisciplinary treatment. Articles published between 2019 and 2020 were reviewed, focusing mainly on the indications for surgical resection for each tumor stage, the treatment of incidental gallbladder cancer, and current trends in minimally invasive surgery for gallbladder cancer.

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National Failure of Surgical Staging for T1b Gallbladder Cancer

Cited by 26 publications

References 14 publications

Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study

Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study

Prognostic Evaluation for Patients over 45 Years Old with Gallbladder Adenocarcinoma Resection: A SEER-Based Nomogram Analysis

Essential updates 2019/2020: Surgical treatment of gallbladder cancer

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