National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning

Lauer, Michael S.; Kiley, James P.; Mockrin, Stephen; Mensah, George A.; Hoots, W. Keith; Patel, Yasin; Cook, Nakela L.; Patterson, Amy P.; Gibbons, Gary H.

doi:10.1161/circulationaha.115.015712

Cited by 5 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40,41 The emergence of TCD ultrasonography as a screening tool to identify patients at highest risk of stroke, coupled with prophylactic monthly blood transfusions, represents an important advance toward the NHLBI goal of a stroke-free generation. 42 The STOP trial demonstrated the efficacy of transfusions to reduce stroke in children with abnormal TCD velocities, 43 but the follow-on STOP 2 trial documented that transfusions were required indefinitely. 44 Despite the documented effectiveness of universal TCD screening programs, [45][46][47] these findings do not translate easily to subSaharan Africa, where blood transfusions are not readily available, safe, or affordable (Table 1).…”

Section: Transcranial Doppler Screeningmentioning

confidence: 99%

Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research

McGann

Hernandez

Ware

2017

Blood

View full text Add to dashboard Cite

Section: Transcranial Doppler Screeningmentioning

confidence: 99%

Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research

McGann

Hernandez

Ware

2017

Blood

View full text Add to dashboard Cite

“…This need is particularly relevant to the success of studies such as the PMI All of Us Research Program, 10 other national research initiatives, 27,28 the future of CVD epidemiology, 3–5 and the development of learning healthcare systems. 7 Although several studies have evaluated the different dimensions of EHR data quality and developed EHR phenotyping algorithms, 16,29–32 they frequently are from a single healthcare institution and use data from clinical care as a gold standard reference, including paper charts, patient and physician interviews, standardized patient encounters, registry data, and claims data.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Leading scientific organizations and experts view leveraging electronic data as essential to the future of cardiology research, public health surveillance, and quality improvement initiatives. 3–9 …”

Section: Introductionmentioning

confidence: 99%

Validity of Cardiovascular Data From Electronic Sources

Ahmad¹,

Chan²,

Rosenman³

et al. 2017

Circulation

View full text Add to dashboard Cite

Background Understanding the validity of data from electronic data research networks is critical to national research initiatives and learning healthcare systems for cardiovascular care. Our goal was to evaluate the degree of agreement of electronic data research networks compared with data collected by standardized research approaches in a cohort study. Methods We linked individual-level data from The Multi-Ethnic Study of Atherosclerosis (MESA), a community-based cohort, with HealthLNK, a 2006–2012 database of electronic health records (EHRs) from six, Chicago health systems. To evaluate the correlation and agreement of blood pressure (BP) in HealthLNK as compared with in-person MESA examinations, and BMI in HealthLNK compared with MESA, we used Pearson Correlation Coefficients and Bland-Altman plots. Using diagnoses in MESA as the criterion standard, we calculated the performance of HealthLNK for hypertension (HTN), obesity, and diabetes diagnosis using ICD-9 codes and clinical data. We also identified potential myocardial infarctions (MIs), strokes, and heart failure events in HealthLNK and compared them with adjudicated events in MESA. Results Of the 1,164 MESA participants enrolled at the Chicago Field Center, 802 (68.9%) participants had data in HealthLNK. The correlation was low for systolic BP (0.39; P<0.0001). Compared with MESA, HealthLNK overestimated systolic BP by 6.5 mmHg (95%CI: 4.2, 7.8). There was a high correlation between BMI in MESA and HealthLNK (0.94; P<0.0001). HealthLNK underestimated BMI by 0.3 kg/m2 (95%CI: −0.4, −0.1). Using ICD-9 codes and clinical data, the sensitivity and specificity of HealthLNK queries for HTN were 82.4% and 59.4%, for obesity were 73.0% and 89.8%, and for diabetes were 79.8% and 93.3%. Compared with adjudicated CVD events in MESA, the concordance rates for MI, stroke, and heart failure were, respectively, 41.7% (5/12), 61.5% (8/13), and 62.5% (10/16). Conclusions These findings illustrate the limitations and strengths of electronic data repositories compared with information collected by traditional standardized epidemiologic approaches for the ascertainment of CVD risk factors and events.

show abstract

“…20 National Heart, Lung, and Blood Institute (NHLBI) emergency-heightening administration guidelines treatment with lung-function testing, peakflow readings, and oxygen saturation directly. 21,22 This guideline cover a diagram for asthma flow which gives common fundamentally and needs local personalization to account medications and scoring for personal ED varieties. The guidelines of NHLBI indicate early asthma diagnosis symptoms and stratified treatment with acute severity.…”

Section: Emergency Department Guidelinesmentioning

confidence: 99%

Clinical guidelines on pediatric asthma exacerbation in emergency department, a narrative review

Jafarnejad

Ebrahimi

2020

Eur J Transl Myol

View full text Add to dashboard Cite

Asthma has been known as a prevalent chronic-type inflammatory disease in children, because of their narrower respiratory airways. The present study aimed to identify guidelines for children asthma treatments. Extensive research was conducted on biomedical and pharmacological bibliographic database PubMed, EMBASE, MEDLINE, LILACS database, global independent network of Cochrane, Science Direct and global health library of Global Index Medicus. A comprehensive literature review was carried out using the terms Pediatric Asthma, epidemiology, management, and related clinical guidelines published from 2000 to 2019. After the primary assessment, quick diagnosis, clinical practice guidelines are useful tools for proper management of pediatric Asthma. By setting proper guidelines for this particular population, a higher improvement in quality of management of of pediatric Asthma is expected. Given the differences between the recommendations arisen by BTS/SIGN and NICE guidelines, critical comparison of the evidence-base guidelines provide suggestions that have more in common than what might seems at the first glance. The analysis of the variations presented in the present article will assist clinicians to make accurate decisions regarding their patients.

show abstract

National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning

Cited by 5 publications

References 9 publications

Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research

Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research

Validity of Cardiovascular Data From Electronic Sources

Clinical guidelines on pediatric asthma exacerbation in emergency department, a narrative review

Contact Info

Product

Resources

About