National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension

doi:10.1001/archinte.1993.00410020042003

Cited by 192 publications

(6 citation statements)

References 7 publications

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“…Long-term follow-up of combined diet and exercise programs has demonstrated success in preventing diabetes while also achieving cost savings (46,47). Among the patients with type 2 diabetes, the average HbA1c reduction was 0.7 percentage points, on par with many glucose-lowering medications (48). Moreover, 50% were able to attain at least a 0.5% reduction in their HbA1c, an amount that has historically been considered clinically meaningful, especially since a positive dose-response association has been reported between HbA1c and cardiovascular outcomes and mortality (34,35).…”

Section: Discussionmentioning

confidence: 99%

Change in cardiometabolic risk factors in a pilot safety-net plant-based lifestyle medicine program

et al. 2023

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IntroductionInterventions emphasizing healthful lifestyle behaviors are proliferating in traditional health care settings, yet there is a paucity of published clinical outcomes, outside of pay-out-of-pocket or employee health programs.MethodsWe assessed weight, hemoglobin A1c (HbA1c), blood pressure, and cholesterol for 173 patients of the Plant-Based Lifestyle Medicine Program piloted in a New York City safety-net hospital. We used Wilcoxon signed-rank tests to assess changes in means, from baseline to six-months, for the full sample and within baseline diagnoses (i.e., overweight or obesity, type 2 diabetes, prediabetes, hypertension, hyperlipidemia). We calculated the percentage of patients with clinically meaningful changes in outcomes for the full sample and within diagnoses.FindingsThe full sample had statistically significant improvements in weight, HbA1c, and diastolic blood pressure. Patients with prediabetes or overweight or obesity experienced significant improvements in weight and those with type 2 diabetes had significant improvements in weight and HbA1c. Patients with hypertension had significant reductions in diastolic blood pressure and weight. Data did not show differences in non-high-density lipoprotein cholesterol (non-HDL-C), but differences in low-density lipoprotein cholesterol (LDL-C) were approaching significance for the full sample and those with hyperlipidemia. The majority of patients achieved clinically meaningful improvements on all outcomes besides systolic blood pressure.ConclusionOur study demonstrates that a lifestyle medicine intervention within a traditional, safety-net clinical setting improved biomarkers of cardiometabolic disease. Our findings are limited by small sample sizes. Additional large-scale, rigorous studies are needed to further establish the effectiveness of lifestyle medicine interventions in similar settings.

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Section: Discussionmentioning

confidence: 99%

Change in cardiometabolic risk factors in a pilot safety-net plant-based lifestyle medicine program

et al. 2023

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“…Our data on initial BPs agree with other findings, supporting a prevalence of hypertension in between 20-30% of the population. [5][6][7][8][9][10] However, when those subjects with raised initial BPs which fell to normal are eliminated, the prevalence is reduced to 15.5%.…”

Section: Discussionmentioning

confidence: 99%

“…5 Larger proportions (between 20% and 30%) have been found in the USA, Canada and the UK and higher still with subjects of Afro-Caribbean and Asian origin. [6][7][8][9][10] Life assurance companies normally request a single BP reading from applicants for life cover and unless the reading exceeds 140/90 mm Hg it is not repeated. When the BP level is more than 140/90 mm Hg insurers request two further recordings, after intervals of five and ten minutes, with the subject at rest.…”

Section: Introductionmentioning

confidence: 99%

Blood pressures in subjects for life assurance medical examination and the effect of ten minutes recumbent rest

Pengelly¹,

Morris²

2012

J R Coll Physicians Edinb

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“…7 T2DM often progresses to combine with HBP in clinical scenarios, and these conditions strongly predispose people to irreversible organ damage as well as organ dysfunction and failure including the retina, kidneys, heart, blood vessels, and nervous system. 8 Metabolomics is assured as the comprehensive quantitative and qualitative analysis of all metabolites in blood, 9 and it is a non-invasive…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus

Yin

Zhao

Liu

et al. 2021

BMJ Open Diab Res Care

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IntroductionType 2 diabetes mellitus (T2DM) is one of the most ordinary metabolic disorders and manifests as a high blood sugar level; 80%–90% of patients with T2DM will develop high blood pressure (HBP), which exacerbates irreversible organ damage. Understanding the metabolic basis of HBP is essential to facilitating early diagnosis and prompt treatments of diabetic complications.Research design and methods34 patients who originally had T2DM and then developed HBP within 1 year were selected from physical examination participants. Using ultrahigh-performance liquid chromatography quadrupole time-of-flight metabolomic analysis, we compared the metabolomic profile of patients with 30 healthy controls. The results showed a clear discrimination in metabolomic profiles between T2DM and T2DM+HBP when employing orthogonal projection to latent structure with discriminant analysis with electrospray ionization modes.ResultsEight differential metabolites changed significantly during disease progression, among which L-isoleucine, L-glutamic acid, pyroglutamic acid and linoleic acid decreased, while sphinganine, Cer(d18:0/16:0), Cer(d18:0/18:0), and citric acid increased. These metabolites are associated with the γ-glutamyl cycle, tricarboxylic acid cycle, and ceramide metabolism.ConclusionsThese novel serum biomarkers may improve the management of T2DM and HBP complications, thus reducing the use of incorrect medical care.

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National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension

Cited by 192 publications

References 7 publications

Change in cardiometabolic risk factors in a pilot safety-net plant-based lifestyle medicine program

Change in cardiometabolic risk factors in a pilot safety-net plant-based lifestyle medicine program

Blood pressures in subjects for life assurance medical examination and the effect of ten minutes recumbent rest

Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus

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