“…To date HCUP has proven useful for the study of congenital heart defects (Connor et al, 2004(Connor et al, , 2005, medical errors associated with the hospital care of premature infants (Kanter et al, 2004), variations in the management of pediatric appendicitis (Smink et al, 2005), and changes in newborn hospitalizations for folate-sensitive birth defects (Robbins et al, 2006). These databases have been used in national injury surveillance (Killingsworth et al, 2005) and to monitor trends in the diagnosis of autism and attention deficit hyperactivity disorder at hospital presentation (Mandell et al, 2005). With careful attention to the strengths and limitations of hospital discharge data, HCUP databases may prove valuable for studying hospitalized children with birth defects.…”