National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): The CASPIAN-III Study

Kelishadi, Roya; Ardalan, Gelayol; Motlagh, Mohammad Esmaeil; Shariatinejad, Keyvan; Heshmat, Ramin; Poursafa, Parinaz; Fakhri, Maryam; Tajadini, Mohamadhasan; Taslimi, Mahnaz

doi:10.1016/j.nut.2013.05.018

Cited by 46 publications

(40 citation statements)

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“…Also the findings from studies that examined only obese or overweight (BMI > 95th or BMI > 85th percentile) subjects (31)(32)(33)(34) were similar and did not differ from those with non-obese subjects (35)(36)(37)(38). Neither socioeconomic status nor physical activity where examined had any effect on the above findings (23,24,26,37).…”

Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentsmentioning

confidence: 73%

“…Twenty of them reported negative/positive associations with IR/IS as assessed by homeostatic model assessment of basal insulin resistance (HOMA-IR), G F , I F , quantitative insulin sensitivity check index (QUICKI-IS), or whole body insulin sensitivity index (WBISI) even after adjustment for BMI, sex, and age when reported (23,24,27,28,30,31,33,34,37,39,42,(43)(44)(45)(46)(47)(48)(49)(50)(51). One study reported that the association disappeared after adjustment for BMI and race (52); one, that it was seen only in the postpubertal age (53); and the rest did not find any such relations (25,32,35,38,41,(54)(55)(56)(57) irrespective of age, sex, or body weight. However, most findings support that IR attributed to vitamin D insufficiency/deficiency may start from early age, irrespective of sex, race/ ethnicity, total adiposity, or central obesity.…”

Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentsmentioning

confidence: 99%

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The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Challa

Makariou

Siomou

2015

Journal of Pediatric Endocrinology and Metabolism

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Among children and adolescents, metabolic syndrome (MetS) is more common than previously believed. Hence, any information on the relation between vitamin D insufficiency/deficiency and insulin resistance (IR) in this population with risk of developing MetS is of great importance. This review analyzes and evaluates the existing evidence from cross-sectional, observational, and retrospective studies concerning the effect of vitamin D insufficiency/deficiency on MetS as a whole or on its various components. Most data show that insufficient vitamin D status is associated with increased prevalence of MetS or its individual components, mainly blood pressure and IR, often independent of overall obesity or abdominal adiposity. The implications of these findings could be associated with increased risk for developing cardiovascular disease and type 2 diabetes mellitus in later life. The very few randomized control trials examining any possible beneficial effects of vitamin D supplementation are also included.

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Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentsmentioning

confidence: 73%

Section: Vitamin D Deficiency and Its Relation To Mets Or Its Componentsmentioning

confidence: 99%

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Challa

Makariou

Siomou

2015

Journal of Pediatric Endocrinology and Metabolism

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“…There is a wealth of epidemiologic evidence that vitamin D deficiency and its concomitant risk factors in the Middle Eastern region, and the Kingdom of Saudi Arabia (KSA) in particular, are very common in both children and adults [12–14]. Despite the overwhelming data, little has been done to address this epidemic on a clinical setting.…”

Section: The Need For Local Guidelinesmentioning

confidence: 99%

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

et al. 2016

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BackgroundVitamin D deficiency is common in the Middle East and in Saudi Arabia, in particular. While several international recommendations on the management of vitamin D deficiency have been documented and practiced globally, these recommendations should be adapted to the conditions of the Middle Eastern region. To address this challenge, the Prince Mutaib Chair for Biomarkers of Osteoporosis (PMCO) in King Saud University (KSU), Riyadh, KSA, together with local experts and in cooperation with the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO), organized a panel that formulated unified recommendations in the diagnosis and treatment of vitamin D deficiency in the region.MethodsThe selection of local and international experts commenced during the 2nd International Vitamin D Symposium conducted in Riyadh, Saudi Arabia, last January 20-–21, 2016. Reviews of the most recent literature were done, and face-to-face meetings were conducted for revisions and final recommendations.Results: Vitamin D sufficiency is defined as circulating serum 25(OH)D ≥50 nmol (≥20 ng/ml) for the general population and vitamin D adequacy as serum 25(OH)D >75 nmol/L l (>30 ng/ml) for the frail and osteoporotic elderly. Despite overwhelming prevalence of vitamin D deficiency, universal screening is not recommended. Recommendations for the general population, children, pregnant/lactating women, post-menopausal women, the elderly, and those with subsequent metabolic diseases were provided.ResultsVitamin D sufficiency is defined as circulating serum 25(OH)D ≥50 nmol (≥20 ng/ml) for the general population and vitamin D adequacy as serum 25(OH)D >75 nmol/L l (>30 ng/ml) for the frail and osteoporotic elderly. Despite overwhelming prevalence of vitamin D deficiency, universal screening is not recommended. Recommendations for the general population, children, pregnant/lactating women, post-menopausal women, the elderly, and those with subsequent metabolic diseases were provided.ConclusionVitamin D supplementation/correction is advised in all persons whose serum 25(OH)D falls below 50 nmol/l (20 ng/ml), and achieving a target of 75 nmol/l (30 ng/ml) is particularly suited for frail, osteoporotic, and older patients. Conducting well-designed clinical trials in the region that will address economic implications and investigations on the treatment persistence and compliance to vitamin D treatment in the region are encouraged.

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“…Even though 1α,25(OH) 2 D 3 (10 −7 M) supplementation can reduce TNF‐α and IL‐6 secretion in PBMC induced by Pam3Cys and LPS in vitro , the ex vivo study found low‐level vitamin D 3 correlated with higher blood pro‐inflammatory cytokine level related to seasonal changes (Khoo and others ). However, some studies found correlation between inflammation marker, obesity, and other cardiometabolic risk factor and hypovitaminosis D (Alemzadeh and others ; Foss ; Bellia and others ; Azizieh and others ; Kelishadi and others ; Reis and others ). In addition, some studies found reduction of fat mass after vitamin D supplementation, but inflammation marker were not investigated (Sadiya and others ; Salehpour and others, ).…”

Section: Resultsmentioning

confidence: 99%

Effects of 1α,25 Dihydroxyvitamin D₃ on Pro‐inflammatory Cytokines of Palmitic Acid Treated Thp‐1 Cells

d'Arqom

Luangwedchakarn

Umrod

et al. 2017

Journal of Food Science

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National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): The CASPIAN-III Study

Cited by 46 publications

References 48 publications

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

Effects of 1α,25 Dihydroxyvitamin D₃ on Pro‐inflammatory Cytokines of Palmitic Acid Treated Thp‐1 Cells

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National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): The CASPIAN-III Study

Cited by 46 publications

References 48 publications

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

Effects of 1α,25 Dihydroxyvitamin D3 on Pro‐inflammatory Cytokines of Palmitic Acid Treated Thp‐1 Cells

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Effects of 1α,25 Dihydroxyvitamin D₃ on Pro‐inflammatory Cytokines of Palmitic Acid Treated Thp‐1 Cells