National semen analysis reference range reporting: adherence to the 1999 World Health Organization guidelines 10 years later

Penn, Heidi A.; Windsperger, Andrew P.; Smith, Zachary L.; Parekattıl, Sıjo J.; Kuang, Wan; Kolettis, Peter N.; Nangia, Ajay K.

doi:10.1016/j.fertnstert.2011.03.004

Cited by 18 publications

(18 citation statements)

References 11 publications

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“…This criterion of sperm quality is useful as a predictor of treatment success as suggested by its associations at numerous points in the reproductive process including impaired fertilization, disrupted preimplantation embryo development, miscarriage and birth defects in the offspring (Bungum et al, 2012;Lewis and Aitken, 2005;Zini, 2011;Zini et al, 2008). Childhood cancers have been also 3 work to WHO guidelines (Keel et al, 2002;Penn et al, 2011;Riddell et al, 2005). It is recommended that semen analysis should be complemented by other clinical assessments (physical examination, history, endocrine and genetic investigations) as appropriate (Esteves et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

Lewis

Aitken

Conner

et al. 2013

Reproductive BioMedicine Online

251

182

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Lewis, S.E.M. et al. (2013). The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment. Astract:Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human spermatozoa is an important attribute of semen quality. It should be part of the clinical work up and properly controlled trials addressing the effectiveness of antioxidant therapy should be undertaken as a matter of urgency. IntroductionMale factor infertility is implicated in more than 40% of couples presenting for assisted reproduction treatment. Conventional semen analysis continues to be the only routine test to diagnose this condition even though it is known that such descriptive assessments cannot discriminate between the spermatozoa of fertile and infertile men (Guzick et al., 2001). The shifting values for normality (all 'normal' values now lower) in the fifth edition of the WHO manual (World Health Organization, 2010) compared with the previous WHO editions may result in even less men being classified as infertile (Murray et al., 2012).

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Section: Introductionmentioning

confidence: 99%

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

Lewis

Aitken

Conner

et al. 2013

Reproductive BioMedicine Online

251

182

View full text Add to dashboard Cite

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“…This edition was unique because it defined the reference values in terms of percentile (Cooper et al, 2010;WHO, 2010;Patel et al, 2018). Penn et al (2011) speculated that in future, such percentile range, rather than the absolute value, might be used to determine the need of intervention.…”

Section: Articlementioning

confidence: 99%

“…Semen analysis is an integral part of evaluation of male partner in an infertile couple (Cooper et al, 2010). It often provides the clue for further management -ranging from the conservative treatment of potentially reversible causes to the advanced treatment like Assisted Reproductive Technology (ART) (Esteves, 2014;Penn et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Adherence to WHO 2010 Recommendations in Relation to Semen Analysis Reports in the Laboratories of West Bengal

Dasgupta¹

2019

FandR

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Background: In 2010, The World Health Organization (WHO) suggested the standards of reporting of semen analysis and the reference values. We tried to determine the adherence to the WHO 2010 standard regarding semen analysis among the laboratories of West Bengal.Methods: An observational study was carried out by collecting the semen analysis reports from different laboratories. Compliance with the WHO 2010 recommendations regarding the reporting of semen analysis and references mentioned was subsequently analyzed.Results: A total of 211 laboratory reports were collected; of which 15 were ART (Assisted Reproductive Technology)-laboratories (7%) and 196 were non-ART-laboratories (93%). More than half of the laboratories did not mention any reference values. Only 7.5% used the phrase "WHO 2010" as the reference. Only 3% of the laboratories reported all the six "important" parameters (volume, pH, sperm concentration, motility, morphology and vitality) and used the WHO 2010 references for all of them. The ART laboratories performed significantly better than their non-ART counterparts in reporting and quoting the WHO 2010 reference values. Conclusion:Even nine years after its introduction, the compliance with the WHO 2010 recommendations on semen analysis was still low among our laboratories. There is need for increased awareness for the laboratory persons in this regard.

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“…Today, a more advanced method called intra cytoplasmic morphologically selected sperm injection (IMSI) is being used and better pregnancy rates are emphasized in many publications [8,9,10]. While sperm DNA disorders is being examined, local hospitals still use basal sperm evaluation values and semen analysis as the easiest way to evaluate testicular function [11,12].…”

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confidence: 99%

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

Bakay¹,

Güven²,

Batioğlu³

et al. 2016

Ann Clin Anal Med

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National semen analysis reference range reporting: adherence to the 1999 World Health Organization guidelines 10 years later

Cited by 18 publications

References 11 publications

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

Adherence to WHO 2010 Recommendations in Relation to Semen Analysis Reports in the Laboratories of West Bengal

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

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