National Strategies to Decrease the Burden of Diabetes and Its Complications

Haw, J. Sonya; Tantry, Shyamanand; Vellanki, Priyathama; Pasquel, Francisco J.

doi:10.1007/s11892-015-0637-y

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…The prevalence of diabetes is increasing rapidly, and type 2 diabetes now accounts for 20–50% of cases of new-onset diabetes in young people (1,2). Diabetic peripheral neuropathy (DN) is the most common complication in both type 1 and type 2 diabetes (3).…”

Section: Introductionmentioning

confidence: 99%

miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2

Liu

et al. 2017

Molecular Medicine Reports

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The present study aimed to investigate the expression status of miRNA-199a-3p in patients with diabetic neuropathy (DN) and the mechanism by which this miRNA is involved in the genesis of DN. The expression of miRNA-199a-3p in plasma of peripheral blood was compared between patients with diabetes and a family history of diabetes and control volunteers by reverse transcription-quantitative polymerase chain reaction (RT-qPCR); in 60 diabetes patients, 45 (75%) demosntrated upregulated miR-199a-3p expression compared with control volunteer plasma. RT-qPCR was also used to detect miRNA-199a-3p expression in paired lower limb skin tissues from 30 patients with DN and 20 control volunteers; miR-199a-3p expression in patients with DN was significantly higher than in the control group. Next miR-199a-3p expression levels were evaluated with respect to the clinic-pathological parameters of diabetes; increased expression of miR-199a-3p was significantly associated with increased disease duration (P=0.041), glycated hemoglobin (HbA1C) levels (P=0.033), and fibrinogen levels (P=0.003). Finally, the effects on downstream mRNA expression levels were investigated as a result of manipulating miR-199a-3p levels. miR-199a-3p overexpression inhibited the expression of the extracellular serine protease inhibitor E2 (SerpinE2). Therefore, it may be hypothesized that miR-199a-3p can induce DN via promoting coagulation in skin peripheral circulation, through the downregulation of SerpinE2. The present findings suggested that miR-199a-3p may have potential as a novel therapeutic target for the treatment of patients with DN.

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Section: Introductionmentioning

confidence: 99%

miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2

Liu

et al. 2017

Molecular Medicine Reports

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“…4 Once diagnosed, intensive glycemic and blood pressure control help reduce the risk of DR progression, however achieving recommended targets in DM care has been a major challenge. 5 Professional societies recommend either annual or biannual eye exams to screen for DR in patients with DM. 6 Compliance with these recommendations is low and the burden outpaces current ability of ophthalmologists to perform screening, especially in geographically distant areas.…”

mentioning

confidence: 99%

Current and Next Generation Portable Screening Devices for Diabetic Retinopathy

Micheletti

Hendrick

Khan

et al. 2016

J Diabetes Sci Technol

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Diabetic retinopathy (DR) is the leading cause of legal blindness in the United States, and with the growing epidemic of diabetes, a global increase in the incidence of DR is inevitable, so it is of utmost importance to identify the most costeffective tools for DR screening. Emerging technology may provide advancements to offset the burden of care, simplify the process, and provide financially responsible methods to safely and effectively optimize care for patients with diabetes mellitus (DM). We review here currently available technology, both in production and under development, for DR screening. Preliminary results of smartphone-based devices, "all-in-one" devices, and alternative technologies are encouraging, but are largely pending verification of utility when used by nonophthalmic personnel. Further research comparing these devices to current nonportable telemedicine strategies and clinical fundus examination is necessary to validate these techniques and to potentially overcome the poor compliance around the globe of current strategies for DR screening.

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“…To respond to the demand for financial efficiency and improved prognosis with better quality of life, disease management has been implemented as a promising program for this purpose [ 6 , 7 ]. This evidence-based approach emphasizes comprehensive care integrated across healthcare delivery systems along the continuum of the disease trajectory [ 8 ]. Disease management includes patient education, especially self-management, consecutive data monitoring, and care coordination with multi-disciplinary health professionals.…”

Section: Introductionmentioning

confidence: 99%

Long-term effectiveness of a disease management program to prevent diabetic nephropathy: a propensity score matching analysis using administrative data in Japan

et al. 2022

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Background Existing reviews indicated that disease management for patients with diabetes may be effective in achieving better health outcomes with less resource utilization in the short term. However, the long-term results were inconsistent because of the heterogeneous nature of the study designs. In the present study, we evaluated the 5-year follow-up results of a local disease management program focused on diabetic nephropathy prevention under the universal public health insurance scheme in Japan. Methods Patients diagnosed with type 2 diabetes who had stage 3 or 4 diabetic kidney disease and were aged between 20 and 75 years were invited to join a disease management program to support self-management and receive a recommended treatment protocol between 2011 and 2013. Follow-up data were collected from an electronic claims database for the public insurance scheme. Considering the non-random selection process, we prepared two control groups matched by estimated propensity scores to compare the incidence of diabetes-related complications, death, and resource utilization. Results The treatment group was more likely to receive clinical management in accordance with the guideline-recommended medication. After propensity score matching, the treatment group had lower incidence of diabetic nephropathy and emergency care use than the control group selected from a beneficiary pool mainly under primary care. Comparisons between the treatment group and the control group with more selected clinical conditions did not show differences in the incidence rate and resource utilization. Conclusions The present results demonstrated limited effectiveness of the program for reducing complication incidence and resource utilization during the 5-year follow-up. Further research on the long-term effectiveness of co-management by primary care physicians, subspecialists in endocrinology and nephrology, and nurse educators is required for effective management of diabetes-related nephropathy.

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National Strategies to Decrease the Burden of Diabetes and Its Complications

Cited by 7 publications

References 70 publications

miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2

miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2

Current and Next Generation Portable Screening Devices for Diabetic Retinopathy

Long-term effectiveness of a disease management program to prevent diabetic nephropathy: a propensity score matching analysis using administrative data in Japan

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