National surveillance of surgical-site infection through register-based analysis of antibiotic use after inguinal hernia repair

Weitoft, Gunilla Ringbäck; Nyrén, Olof; Dickman, Paul W.; Ericsson, Örjan; Struwe, Johan

doi:10.1002/bjs.7261

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In the remaining 98.7% of the patients, a prescription to an antibiotic could be traced to a specific infection diagnosis [37]. A Swedish study in patients who underwent inguinal hernia repair found that the risk of antibiotic treatment during the post-surgical period was of the same order of magnitude as infection rates reported in the Swedish Hernia Register and review studies and concluded that surveillance of postoperative antibiotic use may be considered as a resource-saving surrogate marker for surgical-site infections [38].…”

Section: Discussionmentioning

confidence: 99%

Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study

et al. 2012

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BackgroundMaternal infection during pregnancy may be a risk factor for epilepsy in offspring. Use of antibiotics is a valid marker of infection.Methodology/Principal FindingsTo examine the relationship between maternal infection during pregnancy and risk of childhood epilepsy we conducted a historical cohort study of singletons born in northern Denmark from 1998 through 2008 who survived ≥29 days. We used population-based medical databases to ascertain maternal use of antibiotics or hospital contacts with infection during pregnancy, as well as first-time hospital contacts with a diagnosis of epilepsy among offspring. We compared incidence rates (IR) of epilepsy among children of mothers with and without infection during pregnancy. We examined the outcome according to trimester of exposure, type of antibiotic, and total number of prescriptions, using Poisson regression to estimate incidence rate ratios (IRRs) while adjusting for covariates. Among 191 383 children in the cohort, 948 (0.5%) were hospitalised or had an outpatient visit for epilepsy during follow-up, yielding an IR of 91 per 100 000 person-years (PY). The five-year cumulative incidence of epilepsy was 4.5 per 1000 children. Among children exposed prenatally to maternal infection, the IR was 117 per 100 000 PY, with an adjusted IRR of 1.40 (95% confidence interval (CI): 1.22–1.61), compared with unexposed children. The association was unaffected by trimester of exposure, antibiotic type, or prescription count.Conclusions/SignificancePrenatal exposure to maternal infection is associated with an increased risk of epilepsy in childhood. The similarity of estimates across types of antibiotics suggests that processes common to all infections underlie this outcome, rather than specific pathogens or drugs.

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Section: Discussionmentioning

confidence: 99%

Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study

et al. 2012

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“…The SPDR includes information regarding the drug, the amount prescribed, the amount dispensed, the date of prescribing and dispensing, the instruction from the prescribing doctor, the level of care and the speciality of the prescribing doctor etc. The SPDR is based on the personal registration number and can therefore be connected to other national healthcare and quality registries in order to evaluate for example postoperative infections [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Validation of reoperations due to infection in the Swedish Hip Arthroplasty Register

Lindgren

Gordon

Wretenberg

et al. 2014

BMC Musculoskelet Disord

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BackgroundComplete or almost complete recording of reoperations is essential to enable a correct interpretation of data in arthroplasty registers. The completeness of recordings due to infection is unknown in the Swedish Hip Arthroplasty Register (SHAR). We therefore used a combination of data from the Swedish Prescribed Drug Register (SPDR) and studies of medical records to validate the data of reoperations due to infection in the SHAR.MethodsAll patients registered for a primary Total Hip Replacement (THR) in the SHAR between July 1, 2005 and December 31, 2008 were selected for the study (45,531 patients with 49,219 THRs) and were matched with the SPDR. All patients with a minimum of 4 weeks of continuous outpatient antibiotic treatment within 2 years after their primary THR (1,989 patients, with 2,219 THRs) were selected for a medical records review to find the THRs reoperated due to infection.Results599 (1.3%) of the THRs had been reoperated within 2 years after the index operation and in 47.4% of these the prosthesis had been revised or extracted. 400 of the THRs were registered for a reoperation in the SHAR resulting in a completeness of 67%.ConclusionsThe completeness of registration due to early infection after THR questions whether the SHAR reoperation data can be used in order to evaluate changes in postoperative infection rates.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2474-15-384) contains supplementary material, which is available to authorized users.

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“…The SPDR is based on the personal registration number and can therefore be connected to other national healthcare and quality registries in order to evaluate, for example, postoperative infections. 14 The SPDR is updated with new prescriptions every month and annually includes about 100 million new prescriptions.…”

Section: Registriesmentioning

confidence: 99%

Deep Infection after Total Hip Replacement: A Method for National Incidence Surveillance

Lindgren

Gordon

Wretenberg

et al. 2014

Infect. Control Hosp. Epidemiol.

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National surveillance of surgical-site infection through register-based analysis of antibiotic use after inguinal hernia repair

Cited by 5 publications

References 28 publications

Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study

Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study

Validation of reoperations due to infection in the Swedish Hip Arthroplasty Register

Deep Infection after Total Hip Replacement: A Method for National Incidence Surveillance

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