National Survey of Adherence, Efficacy, and Side Effects of Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder in Taiwan

Gau, Susan Shur-Fen; Chen, Shin-Jaw; Chou, Wen-Jiun; Cheng, Helen; Tang, Ching-Shu; Chang, Hsueh‐Ling; Tzang, Ruu‐Fen; Wu, Yu‐Yu; Huang, Yu‐Huei; Chou, Miao-Chun; Liang, Hsin-Yi; Hsu, Ya-Chen; Lu, Huihua; Huang, Yu‐Shu

doi:10.4088/jcp.v69n0118

Cited by 104 publications

(91 citation statements)

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“…The family history of ADHD needs to be taken into account in children and adolescents treated for ADHD, because it may have negative effects on adherence to ADHD medication in children (Gau et al, 2008;Hong et al, 2013).…”

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

“…In asthma, one review reported that increasing number of medications was associated with lower adherence (Ahmad & Sorensen, 2016). In children with ADHD, increased dose frequency of ADHD medication had a negative effect on adherence (Gau et al, 2008).…”

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

“…In asthma, more severity has been shown to promote adherent behaviour (Bolman, Arwert, & Völlink, 2011). In ADHD, children with more serious ADHD symptoms had poor adherence (Gau et al, 2008).…”

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

“…Low adherence to long-term therapy may influence treatment effects (Gau et al, 2008;Hong et al, 2013;Murphy et al, 2012), which in turn affect people's health (Sabaté, 2003;Stern et al, 2006;Williams et al, 2011). This is a concern, because some studies have found that about 50% of those on prescribed medication are reported to not adhere to the pharmacological therapy recommended by health care providers (Sabaté, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Because suboptimal adherence in these disorders may have serious consequences (Gau et al, 2008;Murphy et al, 2012;Stern et al, 2006), it is important to identify those individuals at risk of non-adherence. Several risk factors for low adherence are known, but the impact of person-related factors, such as personality traits, beliefs about medication and illness perception, has been insufficiently explored in relation to both asthma and ADHD.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Emilsson¹

2017

Linköping University Medical Dissertations

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Adherence to medication in asthma and attention deficit hyperactivity disorder (ADHD) is important because medication may prevent serious consequences, possibly with lifelong effects. Several factors have been identified that influence adherence to medication in these disorders, but the importance of personality traits, beliefs about medication and illness perception has been insufficiently explored. The overall aim of this thesis was to study adherence to medication in asthma and ADHD, and in particular factors associated with adherence.The participants (n=268) in Study I were recruited epidemiologically and consisted of young adults with asthma, aged 22 years (±1 year). Impulsivity and, in men Antagonism and Alexithymia were associated with low adherence among respondents with regular asthma medication (n=109). The participants (n=35) in Study II were recruited from primary care clinics and consisted of adults (mean age 53 years). In men, Neuroticism was associated with low adherence, but Conscientiousness with high adherence. Beliefs about the necessity of medication were positively associated with adherence behaviour in women. In the total sample, a positive necessity-concern differential of beliefs predicted higher adherence. The participants in Study III, IV (n=101) and V (n=99) were recruited from Child and Adolescent Psychiatric clinics and consisted of adolescents with ADHD on long-term ADHD medication. Study IV assessed the reliability and validity of Swedish translations of the Beliefs about Medicines Questionnaire-specific (BMQ-Specific) and Brief Illness Perception Questionnaire (B-IPQ) for use in adolescents with ADHD. Exploratory Principal Component Analysis (PCA) loadings of the BMQ-Specific items confirmed the original components, the specific-necessity and specific-concerns. The exploratory PCA for B-IPQ revealed two components; the first one, B-IPQ Consequences, captured questions regarding perceptions of the implication of having ADHD (items 1, 2, 5, 6 and 8) and the second one, B-IPQ-Control, the perceptions of the ability to manage the ADHD disorder (items 3, 4 and 7). Adherence correlated positively with BMQnecessity-concern differential but negatively with beliefs about medication regarding concerns and side effects as well as Antagonism. Adolescents with more beliefs in the necessity, but with less concerns and side effects were less intentionally non-adherent. Adolescents with more perceptions that ADHD affected life showed less unintentional non-adherence. Negative Affectivity was associated with beliefs in the necessity of medication, but also with concern about medication and side effects. Negative Affectivity was positively associated with perceived consequences in life caused by ADHD and less control over ADHD. Hedonic Capacity was associated with less concerns about medication. In conclusion: In asthma and ADHD, adherence was associated with personality and beliefs about medications treatment. The personality traits showed numerous associations with perception about ADHD a...

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Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Emilsson¹

2017

Linköping University Medical Dissertations

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Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

Storebø

Pedersen

Ramstad

et al. 2018

Cochrane Database of Systematic Reviews

244

161

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Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate. Our certainty in the evidence is very low, and accordingly, it is not possible to accurately estimate the actual risk of adverse events. It might be higher than reported here.Given the possible association between methylphenidate and the adverse events identified, it may be important to identify people who are most susceptible to adverse events. To do this we must undertake large-scale, high-quality RCTs, along with studies aimed at identifying responders and non-responders.

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Neural correlates of atomoxetine improving inhibitory control and visual processing in Drug‐naïve adults with attention‐deficit/hyperactivity disorder

Fan

Chou

Gau

2017

Human Brain Mapping

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Atomoxetine improves inhibitory control and visual processing in healthy volunteers and adults with attention-deficit/hyperactivity disorder (ADHD). However, little is known about the neural correlates of these two functions after chronic treatment with atomoxetine. This study aimed to use the counting Stroop task with functional magnetic resonance imaging (fMRI) and the Cambridge Neuropsychological Test Automated Battery (CANTAB) to investigate the changes related to inhibitory control and visual processing in adults with ADHD. This study is an 8-week, placebo-controlled, double-blind, randomized clinical trial of atomoxetine in 24 drug-naïve adults with ADHD. We investigated the changes of treatment with atomoxetine compared to placebo-treated counterparts using the counting Stroop fMRI and two CANTAB tests: rapid visual information processing (RVP) for inhibitory control and delayed matching to sample (DMS) for visual processing. Atomoxetine decreased activations in the right inferior frontal gyrus and anterior cingulate cortex, which were correlated with the improvement in inhibitory control assessed by the RVP. Also, atomoxetine increased activation in the left precuneus, which was correlated with the improvement in the mean latency of correct responses assessed by the DMS. Moreover, anterior cingulate activation in the pre-treatment was able to predict the improvements of clinical symptoms. Treatment with atomoxetine may improve inhibitory control to suppress interference and may enhance the visual processing to process numbers. In addition, the anterior cingulate cortex might play an important role as a biological marker for the treatment effectiveness of atomoxetine. Hum Brain Mapp 38:4850-4864, 2017. © 2017 Wiley Periodicals, Inc.

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National Survey of Adherence, Efficacy, and Side Effects of Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder in Taiwan

Cited by 104 publications

References 0 publications

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

Neural correlates of atomoxetine improving inhibitory control and visual processing in Drug‐naïve adults with attention‐deficit/hyperactivity disorder

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