National Transplantation Pregnancy Registry—outcomes of 154 Pregnancies in Cyclosporine-Treated Female Kidney Transplant Recipients

Armenti, Vincent T.; AHLSWEDE, KARL M.; AHLSWEDE, BETH ANNE; Jarrell, Bruce E.; Moritz, Michael J.; BURKE, JAMES F.

doi:10.1097/00007890-199402270-00004

Cited by 215 publications

(88 citation statements)

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“…Although SLE, renal transplantation and the maternal-fetal unit of pregnancy are a complex set of conditions, most outcomes were favorable for the mother, newborn and the graft. The outcomes were comparable to our cohort of renal recipients with other diagnoses, and to those previously reported (39,51). Post-pregnancy graft loss was uncommon and was the same as for recipients with other diagnoses.…”

Section: Resultssupporting

confidence: 89%

“…Graft loss within 2 years of delivery was found to be infrequent. Rates of graft loss within 2 years of pregnancy in non-SLE recipients have been previously reported and were similar to this series (34,53). The role of pregnancy in graft survival is difficult to assess.…”

Section: Graft Losssupporting

confidence: 89%

“…The renal transplant literature reports successful pregnancies maintained on prednisone, azathioprine, and/or cyclosporine (23,32,38,39). All three drugs have been used successfully during pregnancy for SLE patients with intact renal function (40)(41)(42).…”

Section: Maternal Factorsmentioning

confidence: 99%

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Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

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This study compares pregnancy outcomes in systemic lupus erythematosus (SLE) patients post renal transplant with recipients with other primary diagnoses, utilizing data from the National Transplantation Pregnancy Registry, Philadelphia, PA. Recipients were referred from transplant centers nationwide. A retrospective analysis was performed using data from questionnaires, hospital records and telephone interviews. Outcomes of pregnancies post renal transplant secondary to lupus nephritis (SLE: n Ω 38; 60 pregnancies) were compared with the pregnancy outcomes of renal recipients with other diagnoses (non-SLE: n Ω 247; 374 pregnancies). Drug-treated hypertension during pregnancy was less common in the SLE group than in the non-SLE group (45.0% vs. 62.5%, p Ω 0.015). There were fewer cesarean sections in the SLE group (30.2 vs. 53.2%, p Ω 0.008). There was no primary or gestational diabetes in the SLE group. There were no other statistical differences in maternal conditions or pregnancy outcomes between the SLE and non-SLE groups, or in the incidence of post pregnancy graft loss. Female recipients transplanted for renal failure secondary to lupus nephritis can successfully maintain pregnancy. Outcomes are comparable to renal recipients with other diagnoses. Newborns in both groups were often premature and had low birthweight. Overall childhood health was reported to be good; there were no apparent predominant structural malformations among the children.

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Section: Resultssupporting

confidence: 89%

Section: Graft Losssupporting

confidence: 89%

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Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

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“…They are also acceptable during breastfeeding. [16][17][18] Mycophenolate mofetil is contraindicated during pregnancy and must be discontinued before conception. 18 Oral contraceptives may be safely used in liver transplant recipients with good allograft function.…”

Section: Correct Answers: B and Cmentioning

confidence: 99%

Hepatobiliary Quiz (Answers)—16 (2015)

Rathi

Dhiman

2015

Journal of Clinical and Experimental Hepatology

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“…Patients are at risk of developing Pneumocystis carinii pneumonia and hence should receive prophylaxis against it. In a study in pregnant women with organ transplant on cyclosporine, growth restriction and prematurity occurred in 40% of the neonates but no congenital defects were seen [Armenti et al 1994;Cockburn et al 1989]. Other side-effects include gingival hyperplasia, hirsutism, anorexia, nausea, vomiting, diarrhea and abdominal discomfort [Sternthal et al 2008].…”

Section: Cyclosporinementioning

confidence: 99%

Review: Ulcerative colitis: current treatment strategies and future prospects

Garud

Peppercorn

2009

Therap Adv Gastroenterol

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Ulcerative colitis (UC) is a disease of unknown etiology characterized by inflammation of the mucosa and occasionally the submucosa of the colon. Conventional drug therapy for UC involves use of aminosalicylates, corticosteroids, azathioprine/6-mercaptopurine, cyclosporine and anti-tumor necrosis factor therapy. Alternative therapies include probiotics, nicotine and fish oil. Drugs like tacrolimus, rosiglitazone and Trichuris suis ova are being evaluated for use in UC patients. With the new biologic agents, new treatment options for UC continue to evolve. In this article we will discuss the conventional drugs, the alternative therapies and the management strategies according to the severity and extent of UC.

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National Transplantation Pregnancy Registry—outcomes of 154 Pregnancies in Cyclosporine-Treated Female Kidney Transplant Recipients

Cited by 215 publications

References 0 publications

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

Hepatobiliary Quiz (Answers)—16 (2015)

Review: Ulcerative colitis: current treatment strategies and future prospects

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