The issue of studying the relationships between indicators of the external structure of the body and spirographic parameters in persons of a certain sex, age, ethno-territorial zoning remains relevant, especially from the point of view of the need to determine the reference values of indicators of external breathing. The purpose of the study was to determine the peculiarities of the relationship between spirographic parameters and indicators of the external structure of the body in practically healthy young women of the mesomorphic constitutional type of the Podilia region of Ukraine. We conducted a complex clinical and laboratory study of young women aged 16 to 20 years, which corresponds to the youthful period of ontogenesis. 109 practically healthy young women were selected, in whom no deviations in the state of health were detected according to the results of radiography, echocardiography, tetrapolar rheovasography and rheoencephalography, sonographic examination of parenchymal organs of the abdominal cavity and thyroid gland, general and biochemical blood analysis. For this group of subjects, we performed a spirographic examination using the Medgraphics Pulmonary Function System 1070 series according to the methodology of the American Pulmonology Association and the European Respiratory Society (2019). The anthropometric study was carried out according to the method of V. V. Bunak (1941), the somatotypological study – according to the calculated modification of the Heath-Carter method (1990). The assessment of the component composition of body weight was carried out according to Matiegka method (1921). After somatotyping, it was found that 32 young women had a mesomorphic type of constitution, for which Spearman’s correlation analysis was conducted in the licensed software package “Statistica 5.5”. It was established that the majority of spirographic indicators in practically healthy young women of the mesomorphic somatotype had isolated statistically significant correlations with anthropo-somatotypological parameters, with the exception of parameters that reflect lung capacities. Vital capacity at rest, had the largest number and strength of correlations, was significantly associated with the value of 24 anthropo-somatotypological indicators. Total, longitudinal and girth body dimensions, the ectomorphic component of the somatotype, muscle, bone and fat mass of the body were most often correlated with the capacity indicators of external respiration. All speed spirographic indicators and maximum peak expiratory flow were correlated with the skinfold thickness. The study of correlations is the basis of further mathematical modeling to determine the appropriate spirographic indicators in an individual representative of the female sex of the juvenile age of the mesomorphic somatotype.