Nationwide comprehensive gastro-intestinal cancer cohorts: the 3P initiative

Braak, Robert R.J. Coebergh van den; Rijssen, L.B. van; Kleef, Jessy Joy van; Vink, Geraldine R.; Berbée, Maaike; Henegouwen, Mark I. van Berge; Bloemendal, Haiko J.; Bruno, Marco J.; Burgmans, Mark C.; Busch, Olivier R.; Coene, P. P. L. O.; Coupé, Veerle M.H.; Dekker, Jan Willem T.; Eijck, Casper H.J. van; Elferink, M.A.G.; Erdkamp, Frans; Grevenstein, Wilhelmina M U van; Groot, Jan Willem B. de; Grieken, Nicole C.T. van; Hingh, Ignace H. J. T. de; Hulshof, Maarten C.C.M.; IJzermans, Jan N.M.; Kwakkenbos, Linda; Lemmens, Valery; Los, Maartje; Meijer, Gerrit A.; Molenaar, I.; Nieuwenhuijzen, Grard A. P.; Noo, Mirre E. de; Poll‐Franse, Lonneke V. van de; Punt, Cornelis J.A.; Rietbroek, R. C.; Roeloffzen, Wilfried; Rozema, Tom; Ruurda, Jelle P.; Sandick, Johanna W. van; Schiphorst, A. H. W.; Schipper, Harvey; Siersema, Peter D.; Slingerland, Marije; Sommeijer, Dirkje W.; Spaander, Manon C.W.; Sprangers, Mirjam A. G.; Stockmann, H. B. A. C.; Strijker, Marin; Tienhoven, Geertjan van; Timmermans, L; Tjin-A-Ton, M.L.R.; Velden, Ankie M.T. van der; Verhaar, Marlies; Verkooijen, Helena M.; Vles, Wouter J.; Vos-Geelen, J. M. P. G. M. de; Wilmink, Johanna W.; Zimmerman, D. D. E.; Oijen, M.G.H. van; Koopman, Miriam; Besselink, Marc G.; Laarhoven, Hanneke W. M. van

doi:10.1080/0284186x.2017.1346381

Cited by 61 publications

(55 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both registries are incorporated within PACAP. 13 Patients provided written informed consent for participation and linkage of their data between the registries. This study was designed in accordance with the STROBE guidelines.…”

Section: Methodsmentioning

confidence: 99%

“…This is a multicenter cohort of patients with pancreatic and periampullary carcinoma for whom clinical data and PROMs are collected. 13 We used this cohort to investigate the relationship between QoL and survival in daily clinical practice. The aim of this study was to examine which domains of QoL are predictive of survival in patients with pancreatic and periampullary cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Mackay¹,

Latenstein²,

Sprangers

et al. 2020

Journal of the National Comprehensive Cancer Network

View full text Add to dashboard Cite

Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015–2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all P<.05) and for patients without resection (ie, overall satisfaction with life, physical and cognitive functioning, QLQ-C30 summary score, fatigue, pain, constipation, diarrhea, and body image; hazard ratios all P<.05). Except for diarrhea, all QoL items accounted for >5% of the additional explained variance and were of added prognostic value. Multivariate analysis using delta QoL revealed that only constipation was of prognostic value for the total cohort, whereas no association with survival was found for subgroups with or without resection. Conclusions: In a multicenter cohort of patients with pancreatic or periampullary carcinoma, QoL scores predicted survival regardless of patient, tumor, and treatment characteristics. QoL scores may thus be used for shared decision-making regarding disease management and treatment choice.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Mackay¹,

Latenstein²,

Sprangers

et al. 2020

Journal of the National Comprehensive Cancer Network

View full text Add to dashboard Cite

show abstract

“…Health related quality of life will be carried out in cooperation with the Prospective Observational Cohort study of Oesophagogastric cancer Patients (POCOP), which is a prospective nationwide study to investigate HRQL in oesophagogastric cancer of all stages [ 20 ]. Health related quality of life will be assessed at baseline (before start preoperative treatment), pre-surgery and from surgery every 3 months in the first year, every 6 months in the second year and yearly thereafter until 5 years.…”

Section: Methodsmentioning

confidence: 99%

CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

et al. 2018

View full text Add to dashboard Cite

BackgroundAlthough radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these regimens suffer from poor patient compliance, particularly in the postoperative phase of treatment. The CRITICS-II trial aims to optimize preoperative treatment by comparing three treatment regimens: (1) chemotherapy, (2) chemotherapy followed by chemoradiotherapy and (3) chemoradiotherapy.MethodsIn this multicentre phase II non-comparative study, patients with clinical stage IB-IIIC (TNM 8th edition) resectable gastric adenocarcinoma are randomised between: (1) 4 cycles of docetaxel+oxaliplatin+capecitabine (DOC), (2) 2 cycles of DOC followed by chemoradiotherapy (45Gy in combination with weekly paclitaxel and carboplatin) or (3) chemoradiotherapy. Primary endpoint is event-free survival, 1 year after randomisation (events are local and/or regional recurrence or progression, distant recurrence, or death from any cause). Secondary endpoints include: toxicity, surgical outcomes, percentage radical (R0) resections, pathological tumour response, disease recurrence, overall survival, and health related quality of life. Exploratory endpoints include translational studies on predictive and prognostic biomarkers.DiscussionThe aim of this study is to select the most promising among three preoperative treatment arms in patients with resectable gastric adenocarcinoma. This treatment regimen will subsequently be compared with the standard therapy in a phase III trial.Trial registrationclinicaltrials.gov NCT02931890; registered 13 October 2016. Date of first enrolment: 21 December 2017.

show abstract

“…[3][4][5][6] In the Netherlands, clinical auditing designed for quality improvement purposes and reduction of unwanted variation in clinical practice has been implemented for many surgical procedures. 7 One of these audits is the Dutch Pancreatic Cancer Audit (DPCA), a mandatory nationwide prospective registry for pancreatic surgery. 6 Monitoring and comparing quality of specific procedures, such as pancreatic resections, requires a broad judgement which may be difficult to obtain.…”

mentioning

confidence: 99%

Textbook Outcome

et al. 2020

View full text Add to dashboard Cite

for the Dutch Pancreatic Cancer Group Background: Textbook outcome (TO) is a multidimensional measure for quality assurance, reflecting the ''ideal'' surgical outcome. Methods: Post-hoc analysis of patients who underwent pancreatoduodenectomy (PD) or distal pancreatectomy (DP) for all indications between 2014 and 2017, queried from the nationwide prospective Dutch Pancreatic Cancer Audit. An international survey was conducted among 24 experts from 10 countries to reach consensus on the requirements for TO in pancreatic surgery. Univariable and multivariable logistic regression was performed to identify TO predictors. Between-hospital variation in TO rates was compared using observed-versus-expected rates. Results: Based on the survey (92% response rate), TO was defined by the absence of postoperative pancreatic fistula, bile leak, postpancreatectomy hemorrhage (all ISGPS grade B/C), severe complications (Clavien-Dindo !III), readmission, and in-hospital mortality. Overall, 3341 patients were included (2633 (79%) PD and 708 (21%) DP) of whom 60.3% achieved TO; 58.3% for PD and 67.4% for DP. On multivariable analysis, ASA class 3 predicted a worse TO rate after PD (ASA 3 OR 0.59 [0.44-0.80]), whereas a dilated pancreatic duct (>3 mm) and pancreatic ductal adenocarcinoma (PDAC) were associated with a better TO rate (OR 2.22 [2.05-3.57] and OR 1.36 [1.14-1.63], respectively). For DP, female sex and the absence of neoadjuvant therapy predicted better TO rates (OR 1.38 [1.01-1.90] and OR 2.53 [1.20-5.31], respectively). When comparing institutions, the observedversus-expected rate for achieving TO varied from 0.71 to 1.46 per hospital after casemix-adjustment. Conclusions: TO is a novel quality measure in pancreatic surgery. TO varies considerably between pancreatic centers, demonstrating the potential benefit of quality assurance programs.

show abstract

Nationwide comprehensive gastro-intestinal cancer cohorts: the 3P initiative

Cited by 61 publications

References 25 publications

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

Textbook Outcome

Contact Info

Product

Resources

About