Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea

Lim, Eunhee; Lee, Jin-Seok; Lee, Eunjung; Jeong, Seok-Ju; Park, Ho-Young; Ahn, Yo-Chan; Son, Chang‐Gue

doi:10.1186/s12967-021-03170-0

Cited by 7 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This discrepancy might be attributed to the relatively fewer studies for adolescents (6 RCTs) and the enrollment of individuals with particularly significant levels of fatigue, as noted by the authors [ 44 ]. Regarding gender difference, it is well acknowledged that females are predominant and more sensitive to fatigue, with approximately 1.5-fold higher prevalence not only in the general population [ 5 ] but also in patients with ME/CFS [ 45 ], along with higher fatigue levels in females. Only 4 RCTs exclusively targeted female patients (4 RCTs, n = 326), which presented higher scores of fatigue severity 84.4 (95% CI 76.2–96.2) compared to 77.4 (95% CI 74.1–80.6) from the rest 56 RCTs (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials

Park,

Lee

et al. 2024

J Transl Med

Self Cite

View full text Add to dashboard Cite

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness medically unexplained, affecting approximately 1% of the global population. Due to the subjective complaint, assessing the exact severity of fatigue is a clinical challenge, thus, this study aimed to produce comprehensive features of fatigue severity in ME/CFS patients. Methods We systematically extracted the data for fatigue levels of participants in randomized controlled trials (RCTs) targeting ME/CFS from PubMed, Cochrane Library, Web of Science, and CINAHL throughout January 31, 2024. We normalized each different measurement to a maximum 100-point scale and performed a meta-analysis to assess fatigue severity by subgroups of age, fatigue domain, intervention, case definition, and assessment tool, respectively. Results Among the total of 497 relevant studies, 60 RCTs finally met our eligibility criteria, which included a total of 7088 ME/CFS patients (males 1815, females 4532, and no information 741). The fatigue severity of the whole 7,088 patients was 77.9 (95% CI 74.7–81.0), showing 77.7 (95% CI 74.3–81.0) from 54 RCTs in 6,706 adults and 79.6 (95% CI 69.8–89.3) from 6 RCTs in 382 adolescents. Regarding the domain of fatigue, ‘cognitive’ (74.2, 95% CI 65.4–83.0) and ‘physical’ fatigue (74.3, 95% CI 68.3–80.3) were a little higher than ‘mental’ fatigue (70.1, 95% CI 64.4–75.8). The ME/CFS participants for non-pharmacological intervention (79.1, 95% CI 75.2–83.0) showed a higher fatigue level than those for pharmacological intervention (75.5, 95% CI 70.0–81.0). The fatigue levels of ME/CFS patients varied according to diagnostic criteria and assessment tools adapted in RCTs, likely from 54.2 by ICC (International Consensus Criteria) to 83.6 by Canadian criteria and 54.2 by MFS (Mental Fatigue Scale) to 88.6 by CIS (Checklist Individual Strength), respectively. Conclusions This systematic review firstly produced comprehensive features of fatigue severity in patients with ME/CFS. Our data will provide insights for clinicians in diagnosis, therapeutic assessment, and patient management, as well as for researchers in fatigue-related investigations.

show abstract

Section: Discussionmentioning

confidence: 99%

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials

Park,

Lee

et al. 2024

J Transl Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fatigue is a long protracted chronic disease that cannot be easily cured within a short time [ 7 ]. Given aging of the global population and the accelerating pace of life, fatigue incidences are increasing annually [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Pityriasis Rosea-Like Eruption following anti-fatigue traditional herbs: Aconitum carmichaelii Debx and Panax Ginseng suspected

Zeng,

Zhou,

Zhang

et al. 2024

BMC Complement Med Ther

View full text Add to dashboard Cite

Traditional herbs have a history of clinical use in anti-fatigue. However, several adverse effects of herbs have been identified. Pityriasis rosea-like eruption (PR-LE) is a rare cutaneous complication of herbs. To the best of our knowledge, there have been few reports of PR-LE following herbs. Here, we described a case of PR-LE that developed 6 days after taking anti-fatigue herbs. After the 17 days of stopping Aconitum carmichaelii Debx and Panax Ginseng, it notably faded. So, when anti-fatigue herbs being authorized for fatigue use, monitoring for potential adverse effects is necessary.

show abstract

“…Fatigue is a long protracted chronic disease that is cannot be easily cured within a short time (76). Currently, multiple mechanisms for fatigue have been proposed, including the free radical hypothesis, metabolite accumulation hypothesis, stress response system hypothesis, among others.…”

Section: Discussionmentioning

confidence: 99%

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Cao

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

IntroductionFatigue has attracted broad attention in recent years due to its high morbidity rates. The use of functional foods to relieve fatigue-associated symptoms is becoming increasingly popular and has achieved relatively good results. In this study, network pharmacology and molecular docking strategies were used to establish the material basis and mechanisms of Chinese herbal compounds in fatigue treatment. According to traditional medicine theories and relevant guidance documents published by the Chinese Ministry of Health, four herbal medicines, including Eucommia ulmoides Oliver bark, Eucommia ulmoides Oliver male flower, Panax notoginseng, and Syzygium aromaticum (EEPS), were selected to constitute the anti-fatigue herbal compound that may be suitable as functional food ingredients.MethodsThe major active ingredients in EEPS were identified via comprehensive literature search and Traditional Chinese Medicine Systems Pharmacology database search. Corresponding targets for these ingredients were predicted using SwissTargetPrediction. The network was constructed using Cytoscape 3.9.1 to obtain key ingredients. Prediction of absorption, distribution, metabolism, excretion and toxicity properties was performed using the ADMETIab 2.0 database. The anti-fatigue targets were retrieved from GeneCards v5.13, OMIM, TTD and DisGeNET 7.0 databases. Then, the potential targets of EEPS in fatigue treatment were screened through a Venn diagram. A protein–protein interaction (PPI) network of these overlapping targets was constructed, and the hub targets in the network selected through topological screening. Gene Ontology and KEGG pathway enrichment analyses were performed using the DAVID database and the bioinformatics online platform. Finally, AutoDock tools were used to verify the binding capacity between the key active ingredients and the core targets.Results and DiscussionThis study identified the active ingredients and potential molecular mechanisms of EEPS in fatigue treatment, which will provide a foundation for future research on applications of herbal medicines in the functional food industry.

show abstract

Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea

Cited by 7 publications

References 33 publications

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials

Pityriasis Rosea-Like Eruption following anti-fatigue traditional herbs: Aconitum carmichaelii Debx and Panax Ginseng suspected

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Contact Info

Product

Resources

About