Nationwide-free preconception care strategy: Experience from China

Xu, Jinghui; Li, Xiaotian; Zhou, Qiongjie

doi:10.3389/fpubh.2022.934983

Cited by 4 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other covariates were collected based on existing literature [28][29][30][31], including sex, maternal age at pregnancy, residence, last year's household income, maternal schooling years, pregestational BMI, history of adverse pregnancy outcomes, history of familial congenital malformations, consanguineous marriages, gestational hypertension during this pregnancy, gestational diabetes mellitus during this pregnancy, lifestyle factors during the first trimester of pregnancy (i.e., smoke and drink alcohols), pregestational folic acid supplementation, and pregestational exposure to antibiotics. A portion of the above questions were documented in the nationwide free prenatal health care system [32]. Certified inquirers conducted face-to-face interviews with mothers to complete the questionnaires.…”

Section: Variablesmentioning

confidence: 99%

Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case–Control Study

Ruan,

Li,

Zhong

et al. 2024

Nutrients

View full text Add to dashboard Cite

This study aimed to explore the association of maternal diet, infant MTHFR gene polymorphisms, and their interactions with the risk of ventricular septal defects (VSDs). This case–control study recruited 448 mothers of VSD children and 620 mothers of healthy counterparts. Multivariable-adjusted logistic regression models were constructed to examine the association between maternal dietary habits during the first trimester of gestation, MTHFR gene polymorphisms, and VSD. Gene–environment interaction effects were analyzed through logistic regression models, with false discovery rate p-value (FDR_p) < 0.05. Maternal excessive intake of fermented bean curd (OR = 2.00, 95%CI: 1.59–2.52), corned foods (OR = 2.23, 1.76–2.84), fumatory foods (OR = 1.75, 1.37–2.23), grilled foods (OR = 1.34, 1.04–1.72), and fried foods (OR = 1.80, 1.42–2.27) was associated with an increased risk of VSD. Regular intake of fish and shrimp (OR = 0.42, 0.33–0.53), fresh eggs (OR = 0.58, 0.44–0.75), soy products (OR = 0.69, 0.56–0.85), and dairy products (OR = 0.71, 0.59–0.85) was found to reduce the occurrence of VSD. Moreover, MTHFR gene polymorphisms at rs2066470 (homozygous: OR = 4.28, 1.68–10.90), rs1801133 (homozygous: OR = 2.28, 1.39–3.74), and rs1801131 (heterozygous: OR = 1.75, 1.24–2.47; homozygous: OR = 3.45, 1.50–7.95) elevated offspring susceptibility to VSDs. Furthermore, significant interactions of MTHFR polymorphisms with maternal dietary habits were observed, encompassing corned foods, fermented bean curd, fried foods, and grilled foods. Maternal dietary habits; MTHFR polymorphisms at rs2066470, rs1801131, and rs1801133; and their interactions were significantly associated with the occurrence of VSDs in offspring.

show abstract

Section: Variablesmentioning

confidence: 99%

Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case–Control Study

Ruan,

Li,

Zhong

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Currently, pre-pregnancy care and pregnancy-related counseling have garnered attention. 16 , 17 Providing an early diagnosis for patients with pregnancy disorders is the basis for subsequent active treatment. Recent studies have detected circulating immune cell subsets for the diagnosis of pregnancy disorders, including RSA and repeated implantation failures (RIF).…”

Section: Introductionmentioning

confidence: 99%

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Lu,

Zhang

2024

IJWH

View full text Add to dashboard Cite

Purpose Female infertility is a global health concern. The aim of this study was to investigate the relationship between regulatory T (Treg) cells and helper T cells 17 (Th17) in peripheral blood and unexplained infertility (UI). In addition, we explored potential valuable diagnostic biomarkers for patients with UI and ascertained whether Treg and Th17 cells are associated with primary and secondary UI. Patients and Methods The patients underwent standard fertility evaluation test, including blood tests, ultrasound examination, fallopian tube tests, ovulation assessment, and male partner’s semen analysis. According to the inclusion and exclusion criteria, this study enrolled 37 patients with UI (30 with primary UI and 7 with secondary UI) and 26 age-matched healthy volunteers as the control group. Flow cytometry was used to detect the frequency of Treg and Th17 cells. The area under the receiver operating characteristic curve (AUC) with a 95% confidence interval (CI) was used to assess the diagnostic performance. An AUC > 0.800 indicated good diagnostic performance. Results The percentage of Treg decreased significantly, whereas the percentage and absolute count of Th17 cells increased. Moreover, the Th17/Treg ratio in patients with UI increased significantly. As a diagnostic biomarker for UI, the Th17/Treg ratio exhibited remarkable diagnostic performance (AUC: 0.813 (95% CI = 0.709–0.917)). However, the percentages and absolute counts of Treg and Th17 cells in the peripheral blood of women with primary and secondary UI, as well as their Th17/Treg ratios, did not differ significantly. Conclusion The distribution of Treg and Th17 cells is imbalanced in patients with UI. Therefore, the Th17/Treg ratio may be a promising indicator of UI. However, there were no significant differences in the distribution of Treg and Th17 cells between women with primary and secondary UI.

show abstract

Prospects for preconception genetic screening at the pregnancy planning stage

Glotov,

Nasykhova,

Dvoynova

et al. 2023

Journal of obstetrics and women's diseases

View full text Add to dashboard Cite

To date, the active introduction of genetic technologies into practical medicine continues in the healthcare sector. The number of genetic diseases is growing, for which different gene therapy and targeted therapy options are emerging. At the same time, the genetic burden in the population is also increasing. The only way to reduce it is the universal introduction of primary preventive programs, the most significant of which is preconception screening, or carrier screening of monogenic diseases. In this review article, various options for preconception screening are considered in detail and the main categories of people for whom such a survey is indicated are identified. The latter are high school students, couples registering a marriage, couples planning a pregnancy, women in early pregnancy, relatives of family members of adolescents with established disabilities, as well as donors of sperm or eggs used in IVF cycles. A detailed historical perspective and examples of various international carrier screening programs for genetic diseases are given in this review. Our analysis shows that sequential testing for monogenic diseases is an appropriate screening strategy (the woman shall be examined first). As part of the screening, the ethnic composition of the population should be taken into account. However, in the case of a mixed population and a high frequency of migration, it is preferable to use an expanded panel that includes the most frequent diseases characteristic of the nationalities inhabiting a certain region. The best results are achieved with mandatory or almost mandatory screening. This review shows the main steps that have been taken in the Russian Federation over the past two years and describes the programs of the Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia. These include free screening programs for family members and relatives of patients with the most common diseases and couples with reproductive loss, as well as a carrier screening program for six major diseases at the expense of the patient. The summary part provides an assessment of the prospects for the practical use of carrier screening in the general population and high-risk groups, as well as for donors of reproductive material, in Russia.

show abstract

Nationwide-free preconception care strategy: Experience from China

Cited by 4 publications

References 79 publications

Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case–Control Study

Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case–Control Study

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Prospects for preconception genetic screening at the pregnancy planning stage

Contact Info

Product

Resources

About