Nationwide Measles and Rubella Outbreaks in South Sudan, 2019

Peck, Megan E; Maleghemi, Sylvester; Kayembe, Lidia; Hercules, Margaret; Anyuon, Atem; Bunga, Sudhir; McFarland, Jeff; Olu, Olushayo Oluseun

doi:10.1093/ofid/ofad032

Cited by 2 publications

(1 citation statement)

References 8 publications

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“… 22 Rubella vaccination is routine in many countries, although it is currently not a component of the childhood vaccination program in Niger. 23 …”

Section: Discussionmentioning

confidence: 99%

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Amza,

Nassirou,

Kadri

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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ABSTRACT. Infectious conjunctivitis outbreaks remain a public health burden. This study focuses on the pathogen and antimicrobial resistance (AMR) profiles identified in Niger. Sixty-two patients with acute infectious conjunctivitis who presented to health posts were enrolled from December 2021 to May 2022. Nasal and conjunctival swabs were obtained from each patient. Unbiased RNA deep sequencing (RNA-seq) was used to identify associated pathogens. A pathogen was identified in 39 patients (63%; 95% CI, 50–74). Of those, an RNA virus was detected in 23 patients (59%; 95% CI, 43–73). RNA viruses were diverse and included human coronaviruses (HCoVs): SARS-CoV-2, HCoV-229E, HCoV-HKU1, and HCoV-OC43. A DNA virus was identified in 11 patients (28%; 95% CI, 17–44). Of those, four patients had a coinfection with an RNA virus and two patients had a coinfection with both an RNA virus and a bacterium. DNA viruses were predominantly human herpesvirus (cytomegalovirus, Epstein–Barr virus, human herpesvirus 8) and human adenovirus species B, C, and F. Eighteen patients (46%; 95% CI, 32–61) had a bacteria-associated infection that included Haemophilus influenza, Haemophilus aegyptius, Staphylococcus aureus, Streptococcus pneumoniae, and Moraxella spp. Antimicrobial resistance determinants were detected in either the conjunctiva or nasal samples of 20 patients (32%; 95% CI, 22–45) and were found to be more diverse in the nose (Shannon alpha diversity, 1.12 [95% CI, 1.05–1.26] versus 1.02 [95% CI, 1.00–1.05], P = 0.01). These results suggest the potential utility of leveraging RNA-seq to surveil pathogens and AMR for ocular infections.

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“… 22 Rubella vaccination is routine in many countries, although it is currently not a component of the childhood vaccination program in Niger. 23 …”

Section: Discussionmentioning

confidence: 99%

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Amza,

Nassirou,

Kadri

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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Measles in the elimination period: the epidemic situation in Voronezh region

Mamchik,

Pobezhimova,

Gabbasovа

et al. 2024

Sanitary Doctor

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Vaccine-preventable diseases, one of which is measles, do not lose their importance and still remain a threat to public health. There is a deterioration in the epidemic situation regarding measles, both in the world and in the Russian Federation. The purpose of the study was to characterize the manifestations of the measles epidemic process in the Voronezh region for the period 1940–2023. The study of morbidity was carried out on the basis of data from Rosstat Form 2, 146 maps of the epidemiological investigation of a case of measles in the Voronezh region for the period 2011–2023 with the calculation of basic statistical indicators. The general availability of effective measles vaccination led to a decrease in the incidence, which by the beginning of the 21st century had become sporadic. However, from 2011 to 2023, there is an upward trend in incidence: rates increased from 0.27 cases (95 % CI 0.06–0.48) to 2.14 per 100 thousand population (95 % CI: 1.54–2,74); the risk group were children (average age 5.70 ± 0.24 years). From 2011 to 2015 imported cases predominated; since 2016 local cases predominated. For 2011–2023 146 cases (81 outbreaks) of measles were registered; among those who fell ill, the majority were not vaccinated against this infection or did not know about their vaccination status. Seroprotection level for the period 2011–2023 averaged 94.09±0.41 %; in certain years, there was an insufficient level of the immune layer in indicator groups of the population 16–17 years old and older. Thus, the pronounced activation of the measles epidemic process in the Voronezh region in recent years is due to a decrease in the immune layer.

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Nationwide Measles and Rubella Outbreaks in South Sudan, 2019

Cited by 2 publications

References 8 publications

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger

Measles in the elimination period: the epidemic situation in Voronezh region

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