Nationwide surveys show that the incidence of recurrent Kawasaki disease in Japan has hardly changed over the last 30 years

Sudo, Daisuke; Nakamura, Yosikazu

doi:10.1111/apa.13773

Cited by 34 publications

(40 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the incidence of KD has increased, the proportion of recurrent KD has remained largely unchanged over the past 30 years (4.4% in 1987–1988 and 4.2% in 2013–2014). Sudo and Nakamura reported that risk factors for recurrence included male sex, young age and initial resistance to IVIG, using the nationwide survey data . We plan to carry out analysis from the epidemiological point of view in the future.…”

Section: Discussionmentioning

confidence: 99%

Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015–2016

Makino

Nakamura

Yashiro

et al. 2019

Pediatrics International

Self Cite

177

163

View full text Add to dashboard Cite

Background: Approximately 50 years have passed since Kawasaki disease (KD) was first reported. The KD nationwide survey began in 1970. Although >360 000 cases have already been reported in Japan, the cause is still unknown. In Japan, the number of patients and incidence rate of KD has continued to increase. It is necessary to examine the trend of the occurrence in the surveillance of KD. Methods: The nationwide survey of patient incidence in 2015 and 2016 was conducted in 2017, as the 24th nationwide survey of KD. A questionnaire was sent to pediatric departments in hospitals with >100 beds and specialized pediatric hospitals, and was responded to by the attending pediatricians. Results: The total number of patients in 2 years was 31 595, and the sex ratio (male/female) was 1.34. The incidence rate (/100 000 children aged 0-4 years/year) was 330.2 (371.2 in boys, 287.3 in girls) in 2015, and 309.0 (343.2 in boys, 273.2 in girls) in 2016. The number of patients by month peaked in January. The age-specific incidence rate according to sex was highest in children between 9 and 11 months of age, after which the incidence rate gradually decreased with advancing age. Conclusions: We summarize the most recent nationwide survey of KD and consider the change in the epidemiologic picture.

show abstract

Section: Discussionmentioning

confidence: 99%

Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015–2016

Makino

Nakamura

Yashiro

et al. 2019

Pediatrics International

Self Cite

177

163

View full text Add to dashboard Cite

show abstract

“…Although the incidence of KD has increased in the past decades, the incidence of recurrent KD has remained largely unchanged over the past 30 years in Japan (3.89–6.51 per 1000 person-years). Risk factors for recurrence KD included male sex, young age and IVIG resistance [44] .…”

Section: Treating Kawasaki Disease and Ivig Resistance With Precisionmentioning

confidence: 99%

Preventing coronary artery lesions in Kawasaki disease

Kuo

2017

Biomedical Journal

View full text Add to dashboard Cite

A form of systemic vasculitis that affects mostly small and medium-sized vessels, Kawasaki disease (KD) is most commonly found in children under the age of 5 years old. Though its etiology is unknown, KD has been the most frequent acquired heart disease in developing countries. Its incidence has increased over recent decades in many centuries, including Japan, Korea, and China. The most severe complications of KD are coronary artery lesions (CAL), including dilation, fistula, aneurysm, arterial remodeling, stenosis, and occlusion. Aneurysm formation has been observed in 20–25% of KD patients that do not receive intravenous immunoglobulin (IVIG) treatment, and in 3–5% that do receive it. Coronary artery dilation has been found in about 30% of KD patients in the acute stage, although mostly in the transient form. Diminishing the occurrence and regression of CAL is a vital part of treating KD. In this review article, I demonstrate the clinical method to prevent CAL formation used at the Kawasaki Disease Center in Taiwan.

show abstract

“…The high incidence of KD in Asian populations globally is strong evidence of a genetic contribution to disease susceptibility. Significant familial associations have been found in KD with a higher incidence rate being reported in children with family members who have previously had an episode of KD [ 5 – 7 ]. Genome wide linkage studies have identified multiple regions that are associated with an increased risk of KD, and genetic polymorphisms for increased risk of KD, further, increased risk of coronary artery abnormalities resulting from KD have been identified [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Environmental epidemiology of Kawasaki disease: Linking disease etiology, pathogenesis and global distribution

et al. 2018

View full text Add to dashboard Cite

BackgroundThe pathogenesis of Kawasaki disease (KD) is commonly ascribed to an exaggerated immunologic response to an unidentified environmental or infectious trigger in susceptible children. A comprehensive framework linking epidemiological data and global distribution of KD has not yet been proposed.Methods and findingsPatients with KD (n = 81) were enrolled within 6 weeks of diagnosis along with control subjects (n = 87). All completed an extensive epidemiological questionnaire. Geographic localization software characterized the subjects’ neighborhood. KD incidence was compared to atmospheric biological particles counts and winds patterns. These data were used to create a comprehensive risk framework for KD, which we tested against published data on the global distribution. Compared to controls, patients with KD were more likely to be of Asian ancestry and were more likely to live in an environment with low exposure to environmental allergens. Higher atmospheric counts of biological particles other than fungus/spores were associated with a temporal reduction in incidence of KD. Finally, westerly winds were associated with increased fungal particles in the atmosphere and increased incidence of KD over the Greater Toronto Area. Our proposed framework was able to explain approximately 80% of the variation in the global distribution of KD. The main limitations of the study are that the majority of data used in this study are limited to the Canadian context and our proposed disease framework is theoretical and circumstantial rather than the result of a single simulation.ConclusionsOur proposed etiologic framework incorporates the 1) proportion of population that are genetically susceptible; 2) modulation of risk, determined by habitual exposure to environmental allergens, seasonal variations of atmospheric biological particles and contact with infectious diseases; and 3) exposure to the putative trigger. Future modelling of individual risk and global distribution will be strengthened by taking into consideration all of these non-traditional elements.

show abstract

Nationwide surveys show that the incidence of recurrent Kawasaki disease in Japan has hardly changed over the last 30 years

Abstract: Although the incidence of KD has increased, the incidence of recurrent KD has remained largely unchanged over the past 30 years. Risk factors for recurrence included male sex, young age and initial resistance to immunoglobulin therapy.

Cited by 34 publications

References 18 publications

Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015–2016

Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015–2016

Preventing coronary artery lesions in Kawasaki disease

Environmental epidemiology of Kawasaki disease: Linking disease etiology, pathogenesis and global distribution

Contact Info

Product

Resources

About