Native aortic valve vegetative endocarditis with Cunninghamella

Mehta, Nehal N.; Romanelli, Jeanine; Sutton, Martin G. St. John

doi:10.1016/j.euje.2003.09.001

Cited by 20 publications

(23 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, these fungi have been implicated in central-venous-catheter-associated fungaemia (Chan-Tack et al, 2005), peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (Branton et al, 1990;Fergie et al, 1992;Nakamura et al, 1989;Nannini et al, 2003;Nayak et al, 2007;Polo et al, 1989;Serna et al, 2003), pleuritis following implantation of drainage catheters (Kimura et al, 2009), endocarditis on native (Mehta et al, 2004;Mitchell et al, 2010) and artificial heart valves (Gubarev et al, 2007;Sanchez-Recalde et al, 1999), osteomyelitis (Chaudhuri et al, 1992;Eaton et al, 1994;Lopes et al, 1995;Meis et al, 1994;Wilkins et al, 2009), and paranasal fungal balls (Goodnight et al, 1993;Kirkpatrick et al, 1979;Lahiri et al, 2001;Robey et al, 2009). Many of these infections are associated with biofilm formation (Costerton et al, 1999;Hall-Stoodley et al, 2004;Loussert et al, 2010) and were reported to exhibit a chronic course (Eaton et al, 1994;Lahiri et al, 2001;Lopes et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

Biofilm formation by zygomycetes: quantification, structure and matrix composition

2011

View full text Add to dashboard Cite

Most studies on fungal biofilms have focused on Candida in yeasts and Aspergillus in mycelial fungi. To the authors’ knowledge, biofilm formation by zygomycetes has not been reported previously. In this study, the biofilm-forming capacity of Rhizopus oryzae, Lichtheimia corymbifera, Rhizomucor pusillus and Apophysomyces elegans was evaluated. At appropriate seeding spore densities, Rhp . oryzae (105 c.f.u. ml−1), L. corymbifera (104 c.f.u. ml−1) and Rhm. pusillus (104 c.f.u. ml−1) produced highly intertwined, adherent structures on flat-bottomed polystyrene microtitre plates after 24 h at 37 °C. The adhered fungal hyphae were encased in an extracellular matrix, as confirmed by phase-contrast and confocal microscopy. The thickness of Rhp. oryzae, L. corymbifera and Rhm. pusillus biofilms was 109.67±10.02, 242±23.07 and 197±9.0 µm (mean±sd), respectively. Biochemical characterization of the biofilm matrix indicated the presence of glucosamine, constituting 74.54–82.22 % of its dry weight, N-acetylglucosamine, glucose and proteins. Adherence and biofilm formation were not observed in A. elegans. Although A. elegans spores germinated at all three seeding densities tested (1×107, 1×106 and 1×105 c.f.u. ml−1), no significant difference was observed (P>0.05) between the A 490 of wells inoculated with A. elegans and the cut-off A 490 for biofilm detection. This study highlights the potential for biofilm formation by at least three medically important species of zygomycetes.

show abstract

Section: Resultsmentioning

confidence: 99%

Biofilm formation by zygomycetes: quantification, structure and matrix composition

2011

View full text Add to dashboard Cite

show abstract

“…2). We identified three additional patients in whom dissemination was likely (164,211,286). All but one of the patients with disseminated infection caused by C. bertholletiae died of the infection (296).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Although rarely diagnosed antemortem, invasion of the heart and/or pericardium is common in reported cases of disseminated C. bertholletiae infection, and it occurred in 62% of infections (n ϭ 13). After the lungs, the heart was the most common organ involved in disseminated infection (67,122,140,161,206,209,211,222,227,236,286,371). Among the patients with heart involvement, the lungs were also affected in 79% of cases (11/14 patients) ( Table 3).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Occasionally, young immunocompromised adults (n ϭ 4) with disseminated C. bertholletiae infections presented with symptoms mimicking myocardial infarction (161,211,222,236). All of these patients experienced chest pain and ischemic changes in electrocardiograms (161,211,222,236), with (222,236) or without elevations in cardiac enzyme levels.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Kobayashi et al (160) documented C. bertholletiae DNAemia that occurred 2 days prior to the appearance of lung infiltrates in a patient with C. bertholletiae pneumonia. A variety of signs, symptoms, and laboratory abnormalities have been reported for patients with disseminated C. bertholletiae infections, including fever (15/20 cases [75%]) (18,122,140,160,161,164,203,206,209,211,222,227,286,344), rigor (122,203), fatigue (122), progressive decline in performance status (140), myalgia (209), arthralgia (209,296), metabolic acidosis (140), respiratory alkalosis (18,164,344), vomitus (140), uremia (140), respiratory distress (161,203,209), loss of consciousness or change in mental status (18,122,161,164,203,206,209,286,344,371), and even signs of septicemia (67), hypotension (203,206), and multiorgan failure (164,…”

Section: Clinical Presentationmentioning

confidence: 99%

See 2 more Smart Citations

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

2011

View full text Add to dashboard Cite

SUMMARY Rhizopus , Mucor , and Lichtheimia (formerly Absidia ) species are the most common members of the order Mucorales that cause mucormycosis, accounting for 70 to 80% of all cases. In contrast, Cunninghamella , Apophysomyces , Saksenaea , Rhizomucor , Cokeromyces , Actinomucor , and Syncephalastrum species individually are responsible for fewer than 1 to 5% of reported cases of mucormycosis. In this review, we provide an overview of the epidemiology, clinical manifestations, diagnosis of, treatment of, and prognosis for unusual Mucormycetes infections (non- Rhizopus , - Mucor , and - Lichtheimia species). The infections caused by these less frequent members of the order Mucorales frequently differ in their epidemiology, geographic distribution, and disease manifestations. Cunninghamella bertholletiae and Rhizomucor pusillus affect primarily immunocompromised hosts, mostly resulting from spore inhalation, causing pulmonary and disseminated infections with high mortality rates. R. pusillus infections are nosocomial or health care related in a large proportion of cases. While Apophysomyces elegans and Saksenaea vasiformis are occasionally responsible for infections in immunocompromised individuals, most cases are encountered in immunocompetent individuals as a result of trauma, leading to soft tissue infections with relatively low mortality rates. Increased knowledge of the epidemiology and clinical presentations of these unusual Mucormycetes infections may improve early diagnosis and treatment.

show abstract

Clinical Syndromes: Mucormycosis

Aigner

Lass-Flörl

2018

Clinically Relevant Mycoses

View full text Add to dashboard Cite

Native aortic valve vegetative endocarditis with Cunninghamella

Cited by 20 publications

References 4 publications

Biofilm formation by zygomycetes: quantification, structure and matrix composition

Biofilm formation by zygomycetes: quantification, structure and matrix composition

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

Clinical Syndromes: Mucormycosis

Contact Info

Product

Resources

About