Native Australian fruit polyphenols inhibit COX-2 and iNOS expression in LPS-activated murine macrophages

Antioxidant capacity and phenolic constituents of Malva neglecta Wallr. and Plantago lanceolata L. from Eastern Anatolia Region of Turkey

“…Studies conducted over the last two decades have shown that phenolic compounds exhibit strong antioxidant capacity (Rice-Evans et al, 1996) and possess a number of physiological activities (Scalbert et al, 2005). They protect cells against oxidative damage by free radicals and activate antioxidant enzymes (Tan et al, 2011a), exhibit pronounced antiinflammatory properties (Tan et al, 2011b), and induce apoptosis of cancer cells (Seeram et al, 2006;Tan et al, 2011c). Epidemiological studies have shown that consumption of polyphenols-rich diet (especially flavonoid-rich diet) may reduce the risk of cardiovascular disease and cancer (Arts and Hollman, 2005).…”

Genus Terminalia: A phytochemical and Biological Review

“…Furthermore, the extract at a dose of 400 mg/kg also reduced the carrageenan-induced leukocyte migration and myeloperoxidase activity in air pouch exudates and exhibited anti-rheumatic and analgesic activities at a dose of 200 mg/kg. T. ferdinandiana fruit had a unique anti-inflammatory activities in lipopolysaccharide-activated murine macrophages, by inhibiting the expression of COX-2 and inducible nitric oxide synthase (iNOS), as well as by inhibiting the production of prostaglandin E 2 [38].…”

A brief review of the application and pharmacology of ethnomedicines of Indigenous Australians

“…91 However, the concentration of active ingredients extracted using modern scientific techniques may vary considerably compared with the dosage obtained following ingestion of the fruits or following traditional methods of extraction. 91 However, the concentration of active ingredients extracted using modern scientific techniques may vary considerably compared with the dosage obtained following ingestion of the fruits or following traditional methods of extraction.…”

“…illawarra plum (Podocarpus elatus), kakadu plum (Terminalia ferdinandiana), muntries (Kunzea pomifera) and native currant (Acrotriche depressa). 91 However, the concentration of active ingredients extracted using modern scientific techniques may vary considerably compared with the dosage obtained following ingestion of the fruits or following traditional methods of extraction. It is interesting to note that although there is little evidence to suggest that Australian aborigines used species of Chamaesyce (Euphorbia) for treatment of skin cancers, extracts have been employed since at least Roman times for skin and other ailments, 98 and more recently, shown to be efficacious in keratoses and non-melanoma skin cancers.…”