“…Moreover, although plant LTR‐RTs tend to be more abundant in the regions of the genome that are considered to be gene‐poor (Julien et al, 2016), genome expansion and evolution may lead to gene family expansion and enrichment to favour the biosynthesis of certain metabolites, such as morphinan in opium poppy (Guo et al, 2018), rubber in rubber tree (Lau et al, 2016), piperine in black pepper (Hu et al, 2019), and caffeine in coffee (Denoeud et al, 2014). Areca nut, as a source of alkaloids, flavonoids, and other secondary metabolites (Manimekalai et al, 2018), has been used as an aphrodisiac, appetite suppressant, digestive aid, and diuretic, as well as a treatment for asthma, cough, dermatitis, fainting, glaucoma, impotence, intestinal worms, leprosy, toothache, leucorrhoea, and vaginal laxity (Bhalla et al, 2015). However, areca nut also represents the fourth most common addiction globally, following tobacco, alcohol, and caffeine (Manimekalai et al, 2018).…”