Natriuretic and diuretic effects of Tropaeolum majus (Tropaeolaceae) in rats

Abstract

The results suggest that HETM could present compound(s) responsible for diuretic activities with no signs of toxicity, and the mechanism could involve prostaglandin system.

Screening for in vivo (anti)estrogenic and (anti)androgenic activities of Tropaeolum majus L. and its effect on uterine contractility

“…In this regard, recently was demonstrated that oral administration of up to 5 g/kg of infusion or hydroethanolic extract obtained from the leaves of Tropaeolum majus did not cause signs of acute toxicity in normotensive rats (Zanetti et al, 2003;Gasparotto et al, 2009). Thus, the objective of the present work Test for androgenecity and antiandrogenicity (Hershberger assay).…”

“…De Medeiros et al (2000) described antithrombotic effect of some extracts of Tropaeolum majus L. leaves. More recently, studies from Gasparotto et al (2009Gasparotto et al ( , 2011a demonstrated diuretic and antihypertensive activity of the ethanolic extract of Tropaeolum majus (HETM), purified fraction and a flavonoid, isoquercitrin, from the leaves of Tropaeolum majus L. Nevertheless, despite many studies on the pharmacological properties of Tropaeolum majus L., several aspects of its safety have not yet been thoroughly studied (Wielanek and Urbanek, 2006). Recently, another species of the same family, Tropaeolum tuberosum, was reported as being able to reduce testicular function in rats following treatment with extracts prepared from the roots (Cardenas-Valencia et al, 2008).…”

Ação acaricida in vitro de Tropaeolum majus sob teleóginas de Rhipicephalus (Boophilus) microplus

“…A T. majus vem sendo utilizada em estudos buscando analisar inúmeras aplicações medicinais (BLOEM et al, 2008;GASPAROTTO JR. et al, 2009;PINTÃO et al, 1995;SANTO et al, 2007;ZANETTI et al, 2003), porém resultados referentes à sua ação acaricida não foram realizados até o presente momento. Pesquisas demonstram a variação de resultados entre extratos de uma mesma planta, como pesquisado por COSTA et al eclodibilidade, sendo entretanto diferente da ação de Citronela de Java (Cymbopogon winterianus Jowitt) a 10%, para a qual não se verificou inibição na postura (MARTINS, 2006).…”

Protective Cardiorenal Effects Of Tropaeolum majus L. In Rats With Renovascular Hypertension

“…No toxic effects were observed after acute treatment or within 28 days of T. majus extract administration. 12,14 In addition, T. majus extract was unable to produce (anti) estrogenic or (anti) androgenic activities in the shortterm in in vivo screening assays. 15 Despite consistent data showing some acute effects on renal and cardiovascular system, no study has investigated whether T. majus extract is able to exert cardiorenal protective effects after 30 days of treatment, i.e.…”

“…Glucosinolates, 7 terpenoids, 8 and flavonoids, mainly isoquercitrin (chemical marker for the quality control), 9 are the three major groups of secondary metabolites in the plant, which have been considered responsible for the medicinal properties. The pharmacological properties attributed to this plant in preclinical studies include antithrombin, 10 antibacterial, 11 diuretic, 12,13 and acute antihipertensive activity. 9 Toxicological parameters of this species were deeply investigated and showed important safety information.…”