Natriuretic hormones II

Ej, Benaksas; Ed, Murray; Wj, Wechter

doi:10.1007/978-3-0348-7164-8_7

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques 1995

DOI: 10.1007/978-3-0348-7164-8_7

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Natriuretic hormones II

Benaksas Ej

Murray Ed

Wechter Wj

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1998

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Cited by 2 publications

References 75 publications

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Has the Elusive ‘Natriuretic Factor’ Been Discovered, and If So, Is It a Hormone?

Ed²

1998

Nephron Exp Nephrol

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This review summarizes the interesting and significant papers reported at the International Conference on Natriuretic and Digitalis-like Factors held at the ASH meeting in San Francisco, June 1–2, 1997. This area of investigation has been rejuvenated as of late with near structural determination of two ouabain-like isolates from human plasma (OLF) and bovine hypothalamus (HIF) which are apparently the same compound and the isolation and structural elucidation of a natriuretic metabolite of γ-tocopherol. Spectroscopic information has also been obtained for two other compounds, an ouabain-like factor from bovine adrenals and HHIF from the hypothalamus. An explanation was offered for how low concentrations of digitalis-like factors can regulate vascular reactivity when the predominant isoform of the sodium pump has a low affinity for these compounds. Various groups are examining possible in vivo synthetic pathways that could lead to the production digitalis-like factors. The natriuretic metabolite of γ-tocopherol, LLU-α, fits deWardener’s postulates for a natriuretic hormone and is being examined for its involvement in ECF control. Once the structures for some of these ouabain-like compounds are determined and they are synthesized, these compounds will also be able to be studied employing classical pharmacologic methods.

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Has the Elusive ‘Natriuretic Factor’ Been Discovered, and If So, Is It a Hormone?

Ed²

1998

Nephron Exp Nephrol

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Koch postulate and digitalis like factors.

Hollenberg

Graves

1995

Hypertens Res

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Substantial, but still circumstantial evidence, supports strongly a role for a circulating digitalis-like factor in the pathogenesis of salt-sensitive hypertension.Although supported by many lines of evidence, this intriguing concept remains controversial,in large part because the responsible factor has proven to be very elusive. A very large number of candidates from a wide range of chemical classes have been proposed. Indeed, the large number of candidates, none supported by absolutely definitive evidence, has contributed to the controversy.In this essay, we have attempted to define the information that will be required before a candidate becomes widely accepted. Because the current situation resembles so strikingly the situation late in the nineteenth century -when efforts focused on the attempt to identify a specific micro-organism as the agent responsible for specific disease -we employed Koch's postulates as the organizing principle. The challenge faced by Robert Koch over a century ago is identical to the challenge that we face today. (Hypertens Res 1995; 18: 1-6)

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Natriuretic hormones II

Cited by 2 publications

References 75 publications

Has the Elusive ‘Natriuretic Factor’ Been Discovered, and If So, Is It a Hormone?

Has the Elusive ‘Natriuretic Factor’ Been Discovered, and If So, Is It a Hormone?

Koch postulate and digitalis like factors.

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