Natriuretic Peptide Deficiency—When There Is Too Little of a Good Thing

Sex Hormones and Change in N-Terminal Pro–B-Type Natriuretic Peptide Levels: The Multi-Ethnic Study of Atherosclerosis

“…The apparently paradoxical roles of NT-proBNP as both a cardioprotective hormone and a biomarker of CVD and HF are likely due to the involvement of NT-proBNP in a negative feedback loop, where there is a compensatory increase in NT-proBNP levels in the setting of pathology. (39) In our study, at baseline, a more androgenic pattern of sex hormones was associated with lower NT-proBNP, which may represent a state of NP deficiency. Over the course of follow-up, a more androgenic and less estrogenic pattern of sex hormones was associated with greater change in NT-proBNP.…”

Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP

“…Natriuretic peptides (NPs) have important physiological functions. Deficiency is associated with HF and fluid retention, and therapies with natriuretic-based therapies may be important in preventing progression along the HF spectrum (5). Cyclic 3′-5′-guanosine monophosphate (cGMP) is the second messenger of the NP system, is metabolized by type V phosphodiesterase (PDEV), and plays an important role in the preservation of myocardial, vascular, and renal function in PSD and HF (6).…”

Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population

“…Further investigations in African Americans would be of relevance as recent studies have established a relative NP deficiency in this ethnic group and studies have also reported excessive aldosteronism in African Americans that may increase the risk for metabolic disease as well as HTN. 24,25,26,27 Additionally, we do not know the sodium intake of each subject. However, recent studies have reported that the average dietary sodium intake in Minnesota is unchanged over the past two decades and exceeds the recommended upper limit of 2300 mg/day.…”