Natriuretic Peptide Levels and Clinical Outcomes Among Patients Hospitalized With Coronavirus Disease 2019 Infection

Aslam, Mohammed; Minhas, Anum; Ghorbani, Anahita; Shade, Julie K.; Jani, Vivek; Hsu, Steven; Sharma, Kavita; Čiháková, Daniela; Hays, Allison G.; Gilotra, Nisha A.

doi:10.1097/cce.0000000000000498

Cited by 1 publication

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References 14 publications

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“…Hemodynamic stress caused by various reasons causes NT-proBNP levels to increase in laboratory results. Many studies suggest that NT-proBNP is frequently elevated in COVID19 patients and has a prognostic significance [22][23][24][25][26] . This increase may mostly be due to possible right ventricular dilatation, or may be due to the virus itself 8 .…”

Section: Introductionmentioning

confidence: 99%

Pulmonary artery diameter and NT-proBNP in patients with Covid-19: Predicting prognosis and mortality

Tastemur,

Olcucuoğlu,

Arik

et al. 2023

Afr H. Sci.

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Background: The diverse and complex presentations of COVID-19 continue to impact the world. Factors related to prognosis and mortality are still not fully illuminated. Objectives: We aimed to asses the relationship of N-terminal pro B-type natriuretic peptide (NT-proBNP) and main pulmonary artery diameter (MPAD) with COVID-19 prognosis and mortality. Methods: 152 COVID-19 patients over the age of 18, were included in the study. Thoracic CT, NT-proBNP values, laboratory and demographic data of these patients were obtained by retrospectively examining the patient files and scanning the results through the patient registry. Results: According to multivariate logistic regression (LR) analysis, high NT-proBNP level (OR=3.542; 95% CI=1.745-9.463; p=0.021) and MPAD/ascending aortic diameter (AAD) ratio>0.75 (OR=2.692; 95% CI=1.264-9.312; p=0.036) were determined as independent risk factors predicting mortality in COVID-19 patients. A significant positive correlation was observed between NT-proBNP level and MPA diameter (r=0.296, p<0.001). The cut-off value was measured as 27.5 mm for MPA diameter and 742 pg/ml for NT-proBNP. Conclusions: Accurate and effective interpretation of available radiological and laboratory data is essential to reveal the factors predicting prognosis and mortality in COVID-19. In this study,we evaluated that the thorax CTs and determined that the MPAD/AAD and NT-proBNP level were independent risk factors in predicting mortality. Keywords: COVID-19; Pulmonary artery diameter; MPAD/AAD ratio; NT-proBNP.

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