Natriuretic peptides and genesis of asthma: An emerging paradigm?☆

Mohapatra, Shyam S.; Lockey, Richard F.; Vesely, David L.; Gower, William R.

doi:10.1016/j.jaci.2004.05.028

Cited by 39 publications

(41 citation statements)

References 73 publications

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“…Receptors for ANP are highly expressed in the lung tissue, including the lung epithelium. Mice deficient in NPRA are resistant to methacholine-induced bronchoconstriction 52 . Another report found that ANP polarizes human DCs towards a Th2-promoting phenotype 36 .…”

Section: Discussionmentioning

confidence: 99%

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

et al. 2015

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“…Previously, we reported that an NH 2 -terminal ANP prohormone peptide comprising residues 73 to 102 (NP73-102) significantly inhibits activation of several proinflammatory transcription factors, including nuclear factor-nB (NF-nB), activator protein 1 and Erk-1,2, in human bronchial epithelial adenocarcinoma A549 cells (20,21). Because these transcription factors augment the local inflammatory milieu, it was reasoned that NPRA signaling plays a role in and promotes tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Kong¹,

Wang

et al. 2008

Cancer Research

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The receptor for atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPRA), is expressed in cancer cells, and natriuretic peptides have been implicated in cancers. However, the direct role of NPRA signaling in tumorigenesis remains elusive. Here, we report that NPRA expression and signaling is important for tumor growth. NPRA-deficient mice showed significantly reduced antigen-induced pulmonary inflammation. NPRA deficiency also substantially protected C57BL/6 mice from lung, skin, and ovarian cancers. Furthermore, a nanoparticle-formulated interfering RNA for NPRA attenuated B16 melanoma tumors in mice. Ectopic expression of a plasmid encoding NP73-102, the NH 2 -terminal peptide of the ANP prohormone, which down-regulates NPRA expression, also suppressed lung metastasis of A549 cells in nude mice and tumorigenesis of Line 1 cells in immunocompetent BALB/c mice. The antitumor activity of NP73-102 was in part attributed to apoptosis of tumor cells. Western blot and immunohistochemistry staining indicated that the transcription factor, nuclear factor-KB, was inactivated, whereas the level of tumor suppressor retinoblastoma protein was upregulated in the lungs of NPRA-deficient mice. Furthermore, expression of vascular endothelial growth factor was downregulated in the lungs of NPRA-deficient mice compared with that in wild-type mice. These results suggest that NPRA is involved in tumor angiogenesis and represents a new target for cancer therapy. [Cancer Res 2008;68(1):249-56]

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“…Many biological functions of mast cells, such as immunoregulation potential [20], antitumar effect [21] and others can be due to their generating ANP.…”

Section: Discussionmentioning

confidence: 99%

The presence of ANP in rat peritoneal mast cells

et al. 2005

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Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells.

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Natriuretic peptides and genesis of asthma: An emerging paradigm?☆

Cited by 39 publications

References 73 publications

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Natriuretic Peptide Receptor A as a Novel Anticancer Target

The presence of ANP in rat peritoneal mast cells

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