Natriuretic peptides in acute kidney injury – A sojourn on parallel tracks?

Dass, Bhagwan; Beaver, Thomas M.; Shimada, Michiko; Alquadan, Kawther F.; Koratala, Abhilash; Singhania, Girish; Singh, Amardeep; Ejaz, A. Ahsan

doi:10.1016/j.ejim.2019.11.025

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Microcirculation Disorder1

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2023

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“…The traditional view holds that pre-renal injury is caused by insufficient renal perfusion, that is, the reduction of renal blood flow is one of the main causes of SAKI [33]. However, novel evidence shows that SAKI can occur without low renal perfusion, but along with stable hemodynamics, or even normal or increased renal blood flow [34].…”

Section: Microcirculation Disordermentioning

confidence: 99%

Research progress on the pharmacological activity and mechanism of chlorogenic acid in alleviating acute kidney injury in sepsis patients

Sun,

Su,

Zhai

et al. 2023

PPM

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Sepsis-induced acute kidney injury (SAKI) is a serious perioperative complication and a common clinical syndrome characterized by a rapid deterioration in renal function with a high incidence of 70%. The causes of SAKI include impaired mitochondrial function of renal tubular epithelial cells, oxidative stress, inflammatory reaction and renal microcirculation disorder. Chlorogenic acid, as a natural product of plant origin, has various biological activities, such as antibacterial, antiviral, and anti-tumor, and plays a significant role in the treatment of SAKI. This article reviews the pharmacological activities of chlorogenic acid and the signaling pathways involved in relieving SAKI, in order to provide a theoretical basis for in-depth study of the mechanisms underlying the alleviation of SAKI and the confirmation of potential therapeutic targets.

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Section: Microcirculation Disordermentioning

confidence: 99%