Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

Jordan, Jens; Birkenfeld, Andreas L.; Melander, Olle; Moro, Cédric

doi:10.1161/hypertensionaha.118.11081

Cited by 54 publications

(44 citation statements)

References 78 publications

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“…Similarly, no difference between groups was observed regarding the ANP protein levels in the heart and immunoreactive ANP concentration in blood (online supplementary Figure S3J-K). This is in line with previous publications which show that cardiac ANP is unaltered, or even reduced, in obesity models like db/db mice, [22][23][24] and that circulating ANP is rapidly eliminated by clearance receptors in adipocytes. 25…”

Section: Echocardiography Validated the Detrimental Effect Of Diabetesupporting

confidence: 93%

Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

Dang

Avolio

Thomas

et al. 2020

European J of Heart Fail

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Homozygosity for a four-missense single-nucleotide polymorphism haplotype of the human BPIFB4 gene is enriched in long-living individuals. Delivery of this longevity-associated variant (LAV) improved revascularisation and reduced endothelial dysfunction and atherosclerosis in mice through a mechanism involving the stromal cell-derived factor-1 (SDF-1). Here, we investigated if delivery of the LAV-BPIFB4 gene may attenuate the progression of diabetic cardiomyopathy.

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Section: Echocardiography Validated the Detrimental Effect Of Diabetesupporting

confidence: 93%

Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

Dang

Avolio

Thomas

et al. 2020

European J of Heart Fail

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“…In terms of SHEs occurring after a CV event including hHF, brain natriuretic peptides may play an important role, as theydamong many other effectsd activate insulin-sensitizing mechanisms at the level of skeletal muscle and adipose tissue and increase circulating concentrations of the insulin-sensitizing hormone adiponectin (34,35). An augmenting effect of atrial natriuretic peptide on insulininduced hypoglycemia has long been known (36).…”

Section: Discussionmentioning

confidence: 99%

Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

et al. 2020

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We sought to confirm a bidirectional association between severe hypoglycemic events (SHEs) and cardiovascular (CV) event risk and to characterize individuals at dual risk. RESEARCH DESIGN AND METHODS In a post hoc analysis of 14,752 Exenatide Study of Cardiovascular Event Lowering (EXSCEL) participants, we examined time-dependent associations between SHEs and subsequent major adverse cardiac events (CV death, nonfatal myocardial infarction [MI] or stroke), fatal/nonfatal MI, fatal/nonfatal stroke, hospitalization for acute coronary syndrome (hACS), hospitalization for heart failure (hHF), and allcause mortality (ACM), as well as time-dependent associations between nonfatal CV events and subsequent SHEs. RESULTS SHEs were uncommon and not associated with once-weekly exenatide therapy (hazard ratio 1.13 [95% CI 0.94-1.36], P 5 0.179). In fully adjusted models, SHEs were associated with an increased risk of subsequent ACM (1.83 [1.38-2.42], P < 0.001), CV death (1.60 [1.11-2.30], P 5 0.012), and hHF (2.09 [1.37-3.17], P 5 0.001), while nonfatal MI (2.02 [1.35-3.01], P 5 0.001), nonfatal stroke (2.30 [1.25-4.23], P 5 0.007), hACS (2.00 [1.39-2.90], P < 0.001), and hHF (3.24 [1.98-5.30], P < 0.001) were all associated with a subsequent increased risk of SHEs. The elevated bidirectional time-dependent hazards linking SHEs and a composite of all CV events were approximately constant over time, with those individuals at dual risk showing higher comorbidity scores compared with those without. CONCLUSIONS These findings, showing greater risk of SHEs after CV events as well as greater risk of CV events after SHEs, validate a bidirectional relationship between CV events and SHEs in patients with high comorbidity scores. In the post-2008 era of cardiovascular outcome trials (CVOTs) mandated by the U.S. Food and Drug Administration (FDA) for any new glucose-lowering drug, severe hypoglycemic events (SHEs) requiring third-party assistance have remained a major challenge complicating diabetes therapy (1). Post hoc analyses of several CVOTs have Munich Diabetes Research Group e.V. at Helmholtz Centre,

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“…92,93 They are known to exert antifibrotic effects 94 and may also have a role in metabolic homeostasis. 95,96 The biological effects of NPs are usually mediated…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Sex‐related differences in contemporary biomarkers for heart failure: a review

Suthahar

Meems

et al. 2020

European J of Heart Fail

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The use of circulating biomarkers for heart failure (HF) is engrained in contemporary cardiovascular practice and provides objective information about various pathophysiological pathways associated with HF syndrome. However, biomarker profiles differ considerably among women and men. For instance, in the general population, markers of cardiac stretch (natriuretic peptides) and fibrosis (galectin‐3) are higher in women, whereas markers of cardiac injury (cardiac troponins) and inflammation (sST2) are higher in men. Such differences may reflect sex‐specific pathogenic processes associated with HF risk, but may also arise as a result of differences in sex hormone profiles and fat distribution. From a clinical perspective, sex‐related differences in biomarker levels may affect the objectivity of biomarkers in HF management because what is considered to be ‘normal’ in one sex may not be so in the other. The objectives of this review are, therefore: (i) to examine the sex‐specific dynamics of clinically relevant HF biomarkers in the general population, as well as in HF patients; (ii) to discuss the overlap between sex‐related and obesity‐related effects, and (iii) to identify knowledge gaps to stimulate research on sex‐related differences in HF.

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Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

Cited by 54 publications

References 78 publications

Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

Sex‐related differences in contemporary biomarkers for heart failure: a review

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