Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Bodrug, Nicolae; Luca, Ecaterina

doi:10.1186/s43168-022-00132-y

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…BNP is predominantly produced by cardiomyocytes due to myocardial wall stress and its increase is related to the overload of cardiac volumes in various cardiac pathologies [67][68][69]. We assume that the findings in our subjects might be associated with repeated intermittent mild hypoxia, which stimulates the production of natriuretic peptides and plays an important role in the development of cardiac structural changes [70,71]. A significant inverse moderate correlation between BNP and HMR in cardiac 123I-MIBG imaging was observed in patients with congestive heart failure in previous studies [72,73].…”

Section: Blood Biomarkersmentioning

confidence: 82%

Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity

Dimiene,

Hoppenot,

Vajauskas

et al. 2024

JCM

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Background: Chronic obstructive pulmonary disease (COPD) has significant systemic manifestations, including cardiovascular morbidity. The main aim of our study was to evaluate the effect of short-term COPD treatment with tiotropium/olodaterol (TIO/OLO) 5/5 μg on cardiac function and autonomic integrity. Methods: Twenty-nine patients with newly diagnosed moderate-to-severe COPD were enrolled. We performed pulmonary function tests, cardiac magnetic resonance, cardiac 123I-metaiodobenzylguanidine (123I-MIBG) imaging and analysis of blood biomarkers on our study subjects. The correlations between the tests’ results were evaluated at baseline. The changes in pulmonary and cardiac parameters from baseline through 12 weeks were assessed. Results: Significant associations between pulmonary function tests’ results and high-sensitivity C-reactive protein (hs-CRP), as well as interleukin-22 (IL-22), were observed at baseline. Treatment with TIO/OLO significantly improved lung function as measured by spirometry and body plethysmography. Moreover, we found that the cardiac index increased from 2.89 (interquartile range (IQR) 1.09) to 3.21 L/min/m2 (IQR 0.78) (p = 0.013; N = 18) and the late heart-to-mediastinum ratio improved from 1.88 (IQR 0.37) to 2 (IQR 0.41) (p = 0.026; N = 16) after 12 weeks of treatment. Conclusions: Treatment with TIO/OLO improves lung function and positively impacts cardiac function and autonomic integrity, suggesting that dual bronchodilation might have a potential in decreasing the risk for cardiac events in COPD. Hs-CRP and IL-22 might be beneficial in determining the intensity of systemic inflammation in COPD. Further research with a larger cohort is needed to enhance the initial results of this study.

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Section: Blood Biomarkersmentioning

confidence: 82%

Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity

Dimiene,

Hoppenot,

Vajauskas

et al. 2024

JCM

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“…2 To illustrate, two studies evaluated NT-proBNP in terms of sensitivity, specificity and predictive values, but used different cut-off values. 27 , 39 Given that levels of BNP and NT-proBNP are already elevated in stable COPD patients, 16 , 17 during an AECOPD, 4 , 43 and in the elderly with COPD, 4 , 27 , 43 it would be advisable to apply higher cut-off values for the differential diagnosis of acute dyspnea in these patients. Before the AHF diagnostic workflow can be specified for COPD patients, future research should define and validate an optimal cut-off value for BNP and NT-pro BNP with not only a high sensitivity, but also a high specificity.…”

Section: Discussionmentioning

confidence: 99%

Lack of Evidence Regarding Markers Identifying Acute Heart Failure in Patients with COPD: An AI-Supported Systematic Review

van Dijk,

Brusse-Keizer,

Bucsán

et al. 2024

COPD

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Background Due to shared symptoms, acute heart failure (AHF) is difficult to differentiate from an acute exacerbation of COPD (AECOPD). This systematic review aimed to identify markers that can diagnose AHF underlying acute dyspnea in patients with COPD presenting at the hospital. Methods All types of observational studies and clinical trials that investigated any marker’s ability to diagnose AHF in acutely dyspneic COPD patients were considered eligible for inclusion. An AI tool (ASReview) supported the title and abstract screening of the articles obtained from PubMed, Scopus, Web of Science, the Cochrane Library, Embase, and CINAHL until April 2023. Full text screening was independently performed by two reviewers. Twenty percent of the data extraction was checked by a second reviewer and the risk of bias was assessed in duplicate using the QUADAS-2 tool. Markers’ discriminative abilities were evaluated in terms of sensitivity, specificity, positive and negative predictive values, and the area under the curve when available. Results The search identified 10,366 articles. After deduplication, title and abstract screening was performed on 5,386 articles, leaving 153 relevant, of which 82 could be screened full text. Ten distinct studies (reported in 16 articles) were included, of which 9 had a high risk of bias. Overall, these studies evaluated 12 distinct laboratory and 7 non-laboratory markers. BNP, NT-proBNP, MR-proANP, and inspiratory inferior vena cava diameter showed the highest diagnostic discrimination. Conclusion There is not much evidence for the use of markers to diagnose AHF in acutely dyspneic COPD patients in the hospital setting. BNPs seem most promising, but should be interpreted alongside imaging and clinical signs, as this may lead to improved diagnostic accuracy. Future validation studies are urgently needed before any AHF marker can be incorporated into treatment decision-making algorithms for patients with COPD. Protocol Registration CRD42022283952.

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“…As an inflammatory factor, CRP will increase in standard when blood vessels are damaged. Also, low standards of hemoglobin can easily induce cerebral embolism [ 14 ]. Comparatively, according to the clinical data of cardiogenic cerebral embolism group and noncardiogenic cerebral embolism group, the hemoglobin and serum NT-proBNP standards of cardiogenic cerebral embolism group were significantly higher than those of noncardiogenic cerebral embolism group.…”

Section: Related Workmentioning

confidence: 99%

The Clinical Noteworthiness of Plasma NT‐ProBNP Standard in Sufferers with Cardiogenic Cerebral Embolism and Its Diagnostic Value for Such Sufferers

Shi

Liu

Li³

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the clinical noteworthiness of plasma NT-proBNP standards in sufferers with cardiogenic cerebral embolism and its diagnostic value for such sufferers, a retrospective study is conducted by the clinical data of sufferers with cerebral embolism. 100 sufferers with cerebral embolism admitted to our hospital from January 2018 to December 2020 are selected. According to the heparin-like drug therapy of acute ischemic stroke test (TOAST) classification criteria, they are divided into cardiac sufferers with cerebral embolism set (43 cases) and noncardiac cerebral embolism set (57 cases). The analysis results show the correlation between serum NT-proBNP standard and neurological impairment score. The detection of-proBNP standard can be used as a diagnostic indicator of disease severity and prognosis for sufferers with cardiogenic cerebral embolism.

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Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Cited by 7 publications

References 45 publications

Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity

Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity

Lack of Evidence Regarding Markers Identifying Acute Heart Failure in Patients with COPD: An AI-Supported Systematic Review

The Clinical Noteworthiness of Plasma NT‐ProBNP Standard in Sufferers with Cardiogenic Cerebral Embolism and Its Diagnostic Value for Such Sufferers

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