Natriuretic Peptides in the Regulation of the Hypothalamic–Pituitary–Adrenal Axis

Porzionato, Andrea; Macchi, Veronica; Ruciński, Marcin; Malendowicz, Ludwik K.; De, Raffaele

doi:10.1016/s1937-6448(10)80001-2

Cited by 33 publications

(25 citation statements)

References 256 publications

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“…CNP was first isolated from porcine brain23 and is distributed throughout the brain and pituitary682425. In the cardiovascular system, CNP is expressed in endothelial cells, where it acts as a vascular mediator regulating local vascular tone and growth9102627.…”

Section: Discussionmentioning

confidence: 99%

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

Nakao

Osawa

Yasoda

et al. 2015

Sci Rep

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Recent studies revealed C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of endochondral bone growth. As they exist ubiquitously in body, we investigated the physiological role of the local CNP/GC-B in the growth plate on bone growth using cartilage-specific knockout mice. Bones were severely shorter in cartilage-specific CNP or GC-B knockout mice and the extent was almost the same as that in respective systemic knockout mice. Cartilage-specific GC-B knockout mice were shorter than cartilage-specific CNP knockout mice. Hypertrophic chondrocyte layer of the growth plate was drastically reduced and proliferative chondrocyte layer, along with the proliferation of chondrocytes there, was moderately reduced in either cartilage-specific knockout mice. The survival rate of cartilage-specific CNP knockout mice was comparable to that of systemic CNP knockout mice. The local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth and might further affect mortality via unknown mechanisms.

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Section: Discussionmentioning

confidence: 99%

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

Nakao

Osawa

Yasoda

et al. 2015

Sci Rep

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“…Various hypertrophic and proinflammatory stimuli such as mechanical stretch, ischemia, endothelin-1, angiotensin II, interleukins, and adrenergic agonists can activate BNP gene transcription 2, 12, 13. BNP is known to have several effects, including natriuresis, diuresis, inhibition of drinking and sympathetic activity in the central nervous system, inhibition of the renin-angiotensin aldosterone system, vascular smooth muscle relaxation, vasodilatation, increase in endothelial permeability, increased lipolysis in adipose tissue, and inhibition of cardiac and vascular remodeling 2, 14. Most circulating BNP derives from the ventricular myocardium under pathophysiological conditions such as heart failure, left ventricular dysfunction, atrial fibrillation, acute coronary syndrome, advanced age, female gender, renal dysfunction, pulmonary disease, and high output states 1-4.…”

Section: Discussionmentioning

confidence: 99%

Plasma B-type Natriuretic Peptide Level in Patients with Acute Cerebral Infarction according to Infarction Subtype and Infarction Volume

Kim¹,

Lee²,

Park³

et al. 2013

Int. J. Med. Sci.

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Background: Plasma B-type natriuretic peptide (BNP) is used as a diagnostic marker of cardiovascular diseases. BNP is secreted mainly from the myocardium and has been detected by immunoreactivity in brain and cerebral arteries. The aim of our study was to investigate plasma BNP in patients with acute cerebral infarction according to infarction subtype and infarction volume.Methods: We studied 141 patients with acute cerebral infarction, classified as large artery atherosclerosis (LAA), cardioembolism (CE), or small vessel disease (SA) according to the Trial of Org 10172 in Acute Stroke Treatment classification. Plasma BNP level was measured in patients and 61 healthy controls. We analyzed various clinical and laboratory variables of patients according to plasma BNP level.Results: Compared to controls, the patients had higher plasma BNP (11.9 ± 11.7 pg/mL versus 124.6 ± 228.8 pg/mL, p <0.01). The highest quartile BNP group was associated with advanced age, female gender, current non-smoker, atrial fibrillation, heart failure, CE group, increased white blood cell counts, increased high sensitivity C-reactive protein, increased left atrium size, decreased left ventricular ejection fraction, increased initial National Institute of Health Stroke Scale, and increased infarction volume. According to multiple regression analysis, CE group, female gender, and infarction volume were independently associated with plasma BNP. Plasma BNP level showed statistically significant differences among LAA (n = 71), CE (n = 50), and SA (n = 20) groups (p <0.001), and the expression decreased in order of CE (253.8 ± 337.1 pg/mL), LAA (61.6 ± 78.8 pg/mL), and SA (25.3 ± 24.8 pg/mL). Increased plasma BNP correlated with increased infarction volume (r = 0.42, p <0.001).Conclusions: Plasma BNP may be helpful for prediction of etiologic classification of acute cerebral infarction and infarction volume.

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“…There are several studies that implicate receptors signaling through NO-independent, cGMP pathways to regulate NET activity. Specifically, members of the atrial natriuretic peptide family (ANP, BNP, CNP) signal through a transmembrane receptor guanylate cyclase and have been reported to stimulate NET activity in brain and adrenal preparations (Fernandez et al, 1990;Porzionato et al, 2010). How the cGMP signal propagates to regulate NET activity has unfortunately not been further pursued, although the second messenger has been reported to induce release of NE in sympathetic terminals via a PKG-dependent phosphorylation and inactivation of PDE3, leading to an elevation of cAMP and activation of PKA (Chan et al, 2012).…”

Section: B Regulation Of Norepinephrine Transporter By Protein Kinase Gmentioning

confidence: 99%

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters

Bermingham

Blakely

2016

Pharmacological Reviews

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Natriuretic Peptides in the Regulation of the Hypothalamic–Pituitary–Adrenal Axis

Cited by 33 publications

References 256 publications

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

Plasma B-type Natriuretic Peptide Level in Patients with Acute Cerebral Infarction according to Infarction Subtype and Infarction Volume

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters

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