Natriuretic Peptides in Valvular Heart Diseases

Choure, Arti J.; Tang, W.H. Wilson; Mills, Roger M.

doi:10.1016/j.hfc.2006.08.001

Cited by 1 publication

(2 citation statements)

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“…These findings are consistent with the results of previously published studies [5,6,7,8,9,10,11,12]. …”

Section: Discussionsupporting

confidence: 94%

“…The circulating levels of these peptides are known to be elevated in response to increased cardiac wall stress and myocardial hypertrophy in states of pressure and/or volume overload [5,6,7,8]. Chronic aortic regurgitation (AR) or aortic stenosis (AS) is known to be associated with increased volume and/or pressure overload of the left ventricle (LV) leading to myocardial hypertrophy with LV dilatation and failure [9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Preoperative, Postoperative and One-Year Follow-Up of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Volume Overload of Aortic Regurgitation: Comparison with Pressure Overload of Aortic Stenosis

et al. 2010

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Objectives: Limited data are available regarding the impact of pressure or volume overload on the clinical or echocardiographic parameters and the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with chronic severe aortic valve diseases. We aimed to investigate and compare the relationships between these parameters in such patients. Methods: One hundred twenty-four consecutive patients who underwent aortic valve replacement for chronic severe aortic valve diseases were enrolled. Plasma NT- proBNP was measured and echocardiographic parameters were recorded before surgery, before discharge and 12 months after surgery. Results: NT-proBNP levels were significantly higher in patients with aortic regurgitation (AR) (n = 63) than in those with aortic stenosis (n = 61) (1,836.0 ± 376.1 vs. 508.4 ± 74.5 pg/ml, p = 0.001). There was a significant relationship between NT-proBNP levels and left ventricular mass index (LVMI) in AR (r = 0.436, p = 0.002) and a weaker, but significant, relationship between NT-proBNP levels and LVMI in aortic stenosis patients (r = 0.290, p = 0.046). In the AR group, preoperative NT-proBNP levels positively correlated with LVMI regression during the 12 months after surgery (r = 0.488, p = 0.001). Conclusion: NT-proBNP levels may reflect LVMI changes that are caused by volume overload rather than pressure overload in chronic aortic valve diseases. Higher preoperative NT-proBNP levels may predict left ventricular reverse remodeling early after surgery for chronic severe AR.

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“…These findings are consistent with the results of previously published studies [5,6,7,8,9,10,11,12]. …”

Section: Discussionsupporting

confidence: 94%