Natural alkaloids from <i>lotus plumule</i> ameliorate lipopolysaccharide-induced depression-like behavior: integrating network pharmacology and molecular mechanism evaluation

Chen, Sixuan; Guo, Wanyi; Qi, Xiaoxiao; Zhou, Jiuyao; Liu, Zhongqiu; Cheng, Yuanyuan

doi:10.1039/c9fo01092k

Cited by 31 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its main ingredient is alkaloids, which have antitumor, antibacterial, anti-inflammatory, and other biological activities (Zhang et al, 2017). Previous studies have shown that alkaloids from other plants have good antidepressant effects (Coetzee et al, 2016;Hamid et al, 2017;Jia et al, 2017;Wu et al, 2018;Arias et al, 2019;Chen et al, 2019;Khan et al, 2019), while the effect of alkaloids from S. alopecuroides on depression and gut microbes has not been investigated. In the current study, we used chronic unpredictable mild stress (CUMS) to establish a depression mouse model and assess the changes in depression-like behaviors and depression-related indicators to evaluate the beneficial effect of alkaloids on CUMS depression-like mice.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Zhang

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of Sophora alopecuroides L.-derived alkaloids on the gut microbiota of mice with depression-like behaviors. We first established a mouse model of depression via chronic unpredictable mild stress (CUMS) and detected changes in depression-like behaviors and depression-related indicators. Simultaneously, 16S rRNA sequencing was performed to investigate gut microbiota changes. Sophora alopecuroides L.-derived alkaloids improved depression-like behaviors and depression-related indicators in mice. The alkaloids decreased the gut microbiota diversity of CUMS mice and depleted intestinal differentially abundant “harmful” microbiota genera. Spearman analysis showed that there is a certain correlation between the differential microbiota (Lactobacillus, Helicobacter, Oscillospira, Odoribacter, Mucispirillum, Ruminococcus), depression-like behaviors, and depression-related indicators. Combined with the predictive analysis of gut microbiota function, these results indicate that alkaloids improve depression in mice through modulating gut microbiota.

show abstract

Section: Introductionmentioning

confidence: 99%

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Zhang

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…in the FST and TST. [230] 4.13.12. Astragaloside IV Astragaloside IV (207, Figure 27) was an active monomer ingredient derived from Astragalus membranaceus (Fisch) Bge, which was traditionally used to treat neurodegenerative diseases.…”

Section: Higenaminementioning

confidence: 99%

Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules

Yao

Jiang

et al. 2022

Advanced Therapeutics

View full text Add to dashboard Cite

Depression is one of the most prevalent mental diseases and a primary cause of disability worldwide with high incidence and high recurrence. The current deterioration of the COVID‐19 epidemic also pushes up the incidence of depression. Nevertheless, the currently available treatments remain inadequate response and limited efficacy. Therefore, discoveries of more potent and safer antidepressant drugs are urgently needed. In this review, the current potential physiological and pathological mechanisms of depression, and the clinical research progresses of candidate drugs as well as the recent advances in small‐molecule drug discovery for potential treatments of depression are systematically summarized. More importantly, the structure–activity relationships of compounds from different classes, the statistical analysis of the blood‐brain barrier permeability, the pharmacological targets, and the in vivo models are comprehensively discussed. Further insights on antidepressant drug discovery are also analyzed from multidimensional perspectives.

show abstract

“…These effects were mediated by serotonin 1A (5-HT1A) receptor [21].. In addition, Chen et al evaluated the effects of the total alkaloids (200 mg/kg) and Higenamine (50 mg/kg) on lipopolysaccharide (LPS)-induced depression by performing forced swim test (FST) and tail suspension test (TST) [22]. Then, the authors indicated molecular mechanism and identified BDNF-mediated ER stress.…”

Section: 1mentioning

confidence: 99%

“…In addition, TLA increases brain-dervived nerotrophic factor BDNF (changing BDNF expression associated with both pathological aging and psychiatric disease). Therefore, lotus plumule tea may provide a potential strategy for preventing depression [22].…”

Section: 1mentioning

confidence: 99%

A review on Extraction of alkaloid from Nelumbo nucifera Embryos and Leaves for Production of Dietary Supplement

Nguyen

Lam

Pham

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Lotus (Nelumbo nucifera Gaertn.) commonly distributed in low-lying and flooded areas like Southern Vietnam provides flowers, leaves, seeds, embryos, and edible rhizomes. All parts of the plant show good pharmacokinetic properties, especially lotus embryos and leaves. Studies have shown that lotus plums and leaves have many bioactive compounds such as alkaloids, flavonoids, triterpenoids, and polyphenols, in which alkaloids are one of mainly bioactive compound kinds. So that, there are many studies investigating extraction methods that increase the amount of alkaloid from lotus leaves, embryos. There are some conventional extract methods such as soak, heat reflux, Soxhlet, etc… and some modern extract methods as microwave, ultrasounds, enzyme assisted, supercritical fluids (S-CO2). At present, lotus leaves, embryos and their bioactivities can have application potential in the supplementary food such as protect-liver, anti-neurotic, etc.. The aim of this paper is to review a variety of develop methods used in the alkaloid extraction from lotus embryos, leaves. Besides, this study also introduces some pharmacokinetic properties of alkaloid which can use in functional foods.

show abstract

Natural alkaloids from lotus plumule ameliorate lipopolysaccharide-induced depression-like behavior: integrating network pharmacology and molecular mechanism evaluation

Abstract: Alkaloids from lotus plumule regulated BDNF-mediated ER stress and autophagy, subsequently attenuating neuroinflammation in LPS-stimulated BV2 microglia and LPS-induced depressive C56BL/6N mice.

Cited by 31 publications

References 34 publications

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Antidepressant Drug Discovery and Development: Mechanism and Drug Design Based on Small Molecules

A review on Extraction of alkaloid from Nelumbo nucifera Embryos and Leaves for Production of Dietary Supplement

Contact Info

Product

Resources

About