Natural and Synthetic Polyampholytes, 2

Kudaibergenov, Sarkyt E.; Ciferri, A.

doi:10.1002/marc.200700197

Cited by 89 publications

(73 citation statements)

References 109 publications

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“…Polyampholytes have a number of unique features [92,93] that have to be taken into consideration when analyzing their mucoadhesive and penetration-enhancing properties. Depending on solution pH and their specific isoelectric point (pI) amphoteric polymers may exist in three different states (positively charged, neutral and negatively charged).…”

Section: Amphoteric Polymersmentioning

confidence: 99%

Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

530

421

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Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives.

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Section: Amphoteric Polymersmentioning

confidence: 99%

Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

530

421

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“…[1][2][3][4][5][6][7][8] Electrostatic interactions between charged monomers lead to the rich behavior of polyelectrolyte solutions which are significantly different from those of uncharged polymers. Compared to neutral polymers, polyelectrolyte theory remains less developed.…”

Section: Introductionmentioning

confidence: 99%

Formation of Complexes between Nanoparticles and Weak Polyampholyte Chains. Monte Carlo Simulations

et al. 2011

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The electrostatic driven complex formation between a weak polyampholyte chain and one positively charged nanoparticle is investigated using Monte Carlo simulations. The influence of parameters such as the polyampholyte contour length, number and size of blocks, nanoparticle surface charge density, and solution properties, such as the pH and ionic concentration, on the PA titration curves is investigated. It is shown that the presence of one positively charged nanoparticle significantly modifies the acid/base properties of the weak polyampholyte by, on the one hand, promoting the formation of negatively charged monomers and, on the other hand, limiting the number of positively charged monomers. The electrostatic interactions of this system can be modified by pH, ionic concentration, and nanoparticle surface charge. The competition between attractive and repulsive, intramolecular and intermolecular electrostatic interactions leads to a wide range of possible PA conformations at the nanoparticle surface, which have a direct impact on the nanoparticle stabilized or destabilized solutions. Extended conformations, electrostatic rosettes, and dense multiplayer structures are observed. Nonetheless, the intramolecular interactions between the positively and negatively charged PA monomers, in particular at the isoelectric point, are found to play important and subtle roles for both the isolated and adsorbed chain conformations. It is also found that nanoparticle charge inversion is an important ingredient for the formation of multilayer structures at the nanoparticle surface.

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“…Also, the supramolecular structure of polyampholyte hydrogels can be tuned to change multiple function properties over wide ranges by diverse functional unit combinations (Sun et al, 2013a). Additionally, excellent water penetration of hydrogel is highly accessible to foreign molecules (Kudaibergenov and Ciferri, 2007). This uniqueness of polyampholyte hydrogel motivates us to exploit this kind of materials as adsorbents for removing heavy metals in water.…”

Section: Introductionmentioning

confidence: 99%

A highly efficient polyampholyte hydrogel sorbent based fixed-bed process for heavy metal removal in actual industrial effluent

et al. 2016

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a b s t r a c tHigh sorption capacity, high sorption rate, and fast separation and regeneration for qualified sorbents used in removing heavy metals from wastewater are urgently needed. In this study, a polyampholyte hydrogel was well designed and prepared via a simple radical polymerization procedure. Due to the remarkable mechanical strength, the three-dimensional polyampholyte hydrogel could be fast separated, easily regenerated and highly reused. The sorption capacities were as high as 216.1 mg/g for Pb(II) and 153.8 mg/g for Cd(II) owing to the existence of the large number of active groups. The adsorption could be conducted in a wide pH range of 3e6 and the equilibrium fast reached in 30 min due to its excellent water penetration for highly accessible to metal ions. The fixed-bed column sorption results indicated that the polyampholyte hydrogel was particularly effective in removing Pb(II) and Cd(II) from actual industrial effluent to meet the regulatory requirements. The treatment volumes of actual smelting effluent using one fixed bed column were as high as 684 bed volumes (BV) (7736 mL) for Pb(II) and 200 BV (2262 mL) for Cd(II). Furthermore, the treatment volumes of actual smelting effluent using tandem three columns reached 924 BV (31,351 mL) for Pb(II) and 250 BV (8483 mL) for Cd(II), producing only 4 BV (136 mL) eluent. Compared with the traditional high density slurry (HDS) process with large amount of sludge, the proposed process would be expected to produce only a small amount of sludge. When the treatment volume was controlled below 209.3 BV (7103 mL), all metal ions in the actual industrial effluent could be effectively removed (<0.01 mg/L). This wok develops a highly practical process based on polyampholyte hydrogel sorbents for the removal of heavy metal ions from practical wastewater.

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Natural and Synthetic Polyampholytes, 2

Cited by 89 publications

References 109 publications

Advances in Mucoadhesion and Mucoadhesive Polymers

Advances in Mucoadhesion and Mucoadhesive Polymers

Formation of Complexes between Nanoparticles and Weak Polyampholyte Chains. Monte Carlo Simulations

A highly efficient polyampholyte hydrogel sorbent based fixed-bed process for heavy metal removal in actual industrial effluent

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