Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete, Sabrina; Dattilo, Marco; Patitucci, Francesco; Pezzi, Giuseppe; Parisi, Ortensia Ilaria; Puoci, Francesco

doi:10.3390/jfb14090455

Cited by 35 publications

(9 citation statements)

References 214 publications

(237 reference statements)

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“…Alginate, CMC and PA are recognised as biocompatible polymers [25][26][27][28][29][30] and TLC was previously shown to be non-cytotoxic on dermal fibroblasts. 31 However, our results demonstrate that BIA (alginate plus CMC) and even more URG (PA plus TLC) are cytotoxic, as also previously reported for other alginate dressings such as Kaltostat®.…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of wound‐dressings on key wound healing properties of dermal fibroblasts

Peltier,

Adib,

Nicosia

et al. 2024

Experimental Dermatology

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Healing of complex wounds requires dressings that must, at least, not hinder and should ideally promote the activity of key healing cells, in particular fibroblasts. This in vitro study assessed the effects of three wound‐dressings (a pure Ca2+ alginate: Algostéril®, a Ca2+ alginate + carboxymethylcellulose: Biatain alginate® and a polyacrylate impregnated with lipido‐colloid matrix: UrgoClean®) on dermal fibroblast activity. The results showed the pure calcium alginate to be non‐cytotoxic, whereas the other wound‐dressings showed moderate to strong cytotoxicity. The two alginates stimulated fibroblast migration and proliferation, whereas the polyacrylate altered migration and had no effect on proliferation. The pure Ca2+ alginate significantly increased the TGF‐β‐induced fibroblast activation, which is essential to healing. This activation was confirmed by a significant increase in Vascular endothelial growth factor (VEGF) secretion and a higher collagen production. The other dressings reduced these fibroblast activities. The pure Ca2+ alginate was also able to counteract the inhibitory effect of NK cell supernatants on fibroblast migration. These in vitro results demonstrate that tested wound‐dressings are not equivalent for fibroblast activation. Only Algostéril was found to promote all the fibroblast activities tested, which could contribute to its healing efficacy demonstrated in the clinic.

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Section: Discussionmentioning

confidence: 99%

In vitro effects of wound‐dressings on key wound healing properties of dermal fibroblasts

Peltier,

Adib,

Nicosia

et al. 2024

Experimental Dermatology

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“…Among these, polysaccharides such as alginate, cellulose, chitosan, and hyaluronic acid are versatile polymers for the development of formulations against skin infections. The efficacy of these biomacromolecules is related to their enhanced biocompatibility, biodegradability, non-toxic nature, chelation, presence of multifunctional groups, and ease of chemical modification [ 421 , 422 , 423 , 424 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Kuperkar,

Atanase,

Bahadur

et al. 2024

Polymers

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Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, and minimal side effects. Here, we present an overview with updated information on natural and synthetic degradable polymers where a brief account on different polysaccharides, proteins, and synthetic polymers viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant to biomedical applications has been provided. The various approaches for the transformation of these polymers by physical/chemical means viz. cross-linking, as polyblends, nanocomposites/hybrid composites, interpenetrating complexes, interpolymer/polyion complexes, functionalization, polymer conjugates, and block and graft copolymers, are described. The degradation mechanism, drug loading profiles, and toxicological aspects of polymeric nanoparticles formed are also defined. Biomedical applications of these degradable polymer-based biomaterials in and as wound dressing/healing, biosensors, drug delivery systems, tissue engineering, and regenerative medicine, etc., are highlighted. In addition, the use of such nano systems to solve current drug delivery problems is briefly reviewed.

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“…Synthetic biomaterials have been used in many applications such as hard and soft tissue engineering, wound healing, and drug delivery due to their bioabsorbability, biocompatibility, low toxicity, controlled synthesis and modification, biodegradability, and compatibility with intended use ( Table 2 ) ( Mir et al, 2018 ; Prete et al, 2023 ). Some common synthetic biomaterials that have been used in wound healing include polyglycolic acid (PGA), polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyethylene oxide (PEO), and polyvinyl pyrrolidone (PVP) ( Qiu and Bae, 2006 ).…”

Section: Biomaterials Used In Wound Healingmentioning

confidence: 99%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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Skin, the largest biological organ, consists of three main parts: the epidermis, dermis, and subcutaneous tissue. Wounds are abnormal wounds in various forms, such as lacerations, burns, chronic wounds, diabetic wounds, acute wounds, and fractures. The wound healing process is dynamic, complex, and lengthy in four stages involving cells, macrophages, and growth factors. Wound dressing refers to a substance that covers the surface of a wound to prevent infection and secondary damage. Biomaterials applied in wound management have advanced significantly. Natural biomaterials are increasingly used due to their advantages including biomimicry of ECM, convenient accessibility, and involvement in native wound healing. However, there are still limitations such as low mechanical properties and expensive extraction methods. Therefore, their combination with synthetic biomaterials and/or adding bioactive agents has become an option for researchers in this field. In the present study, the stages of natural wound healing and the effect of biomaterials on its direction, type, and level will be investigated. Then, different types of polysaccharides and proteins were selected as desirable natural biomaterials, polymers as synthetic biomaterials with variable and suitable properties, and bioactive agents as effective additives. In the following, the structure of selected biomaterials, their extraction and production methods, their participation in wound healing, and quality control techniques of biomaterials-based wound dressings will be discussed.

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Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Cited by 35 publications

References 214 publications

In vitro effects of wound‐dressings on key wound healing properties of dermal fibroblasts

In vitro effects of wound‐dressings on key wound healing properties of dermal fibroblasts

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

A review of the current state of natural biomaterials in wound healing applications

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