Natural and Synthetic Polymers Assisted Development of Lurasidone Hydrochloride Intranasal Mucoadhesive Microspheres

Khan, Suhail Ayoub; Gangane, Purushottam; Mahapatra, Debarshi Kar; Mahajan, Nilesh

doi:10.5530/ijper.54.1.25

Cited by 14 publications

(6 citation statements)

References 12 publications

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“…[22] Drug and excipient mixed in the ratio of 1:1 (w/w) used to exaggerate the drug-excipient interactions which will be easier to examine. [23] Yield: Yield percentage was calculated by the equation below by using final mass of the product with respect to total theoretical mass of drug and polymer [24] while sensitive electronic balance by Wensar was used:…”

Section: Methodsmentioning

confidence: 99%

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

2022

pnr

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This research work designed to overcome the problems associated with poorly aqueous soluble drug. Fenofibrate (FENO) being BCS Class II drug shows low solubility but permeability is high. Compatibility of the drug and polymer studies was done by FTIR. Physical mixtures (PM) of the drug and polymer HPMCAS were prepared by trituration method. Fenofibrate solid dispersions (SD) were prepared by common solvent technique ascribed feasibility in laboratory scale. Physical state of formulations was characterized by powder XRD, TGA. Solubility of pure drug (FENO), Physical mixture and SD found to be 0.3, 0.78±0.15 to 1.15±0.28 and 2.17±0.37 to 3.25±0.14 mg/ml respectively. Percentage yield and percentage drug content were determined and found within satisfactory range. The maximum cumulative percentage of drug release from pure drug (FENO), Physical mixture and SD found to be 34.5%, 72.1 and 97.2% respectively at 60 minutes. Microscopy (SEM) study was found that the prepared solid dispersion has porous morphology. The present study establishes the increased bioavailability of the optimized batch when compared with the pure FENO. There was significant (50%) increase in absorption of Fenofibrate observed from the in vitro everted gut sac model. SD of FENO was developed successfully. The solubility of FENO was ameliorated significantly while compared with API (pure FENO). This research work found formulation of SD preferable technique to enhance solubility and enhance dissolution of lipophilic drugs.

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Section: Methodsmentioning

confidence: 99%

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

2022

pnr

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“…The microspheres prepared by various solvents dried it and weighed their percentage yield (w/w) with the total amount of drug and polymers was determined by using formula [13,14] % Yield= 𝐀𝐦𝐨𝐮𝐧𝐭 𝐨𝐟 𝐝𝐫𝐢𝐞𝐝 𝐦𝐢𝐜𝐫𝐨𝐬𝐩𝐡𝐞𝐫𝐞𝐬 𝐫𝐞𝐜𝐨𝐯𝐞𝐫𝐞𝐝 𝐀𝐦𝐨𝐮𝐧𝐭 𝐨𝐟 𝐝𝐫𝐮𝐠+𝐀𝐦𝐨𝐮𝐧𝐭 𝐨𝐟 𝐩𝐨𝐥𝐲𝐦𝐞𝐫…”

Section: Production Percentage Yield (W/w)mentioning

confidence: 99%

Study an effect of various orgainic solvents for preparation of glipizide mucoadhesive microspheres

Verma

Kumari

2022

ijhs

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Glipizide is a potent, rapid-acting with short duration of action and well tolerated second-generation sulfonylureas effective in reducing postprandial glucose level. However, if a dosage is missed before a meal, the risk of postprandial hypoglycemia and post-meal glucose excursions is always linked with the use of glipizide for the treatment of type 2 diabetes mellitus. Type 2 diabetes mellitus is a polygenic illness that includes both insulin secretion dysfunction and peripheral insulin resistance. (1)The study an effect of organic solvents preparation of glipizide controlled released mucoadhesive microspheres. (2)The microspheres were formulated conventional tremendous technique by emulsion solvent evaporation technique. (3) Mucoadhesive microspheres were evaluation parameters Examine by their impact on mucoadhesion, drug encapsulation efficacy (EE%), and in-vitro drug release. The produced microspheres were subjected to physical characterizations such as FTIR, DSC, particle analyzer, and SEM. Using cock stomach tissue, the ex-vivo mucoadhesive properties of the various orgainic solvents microspheres were studied. When compared to the other solvents microspheres employing, such as ethanol, methanol, acetone, glipizide loaded ethanol mucoadhesive microspheres had a higher EE percent (83.63±0.17%), a more sustained release profile over 10 hours, and superior adherence to cock stomach mucosa.

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“…A selection of kinetic models were used to map the combined drug release data collected from in vitro drug release studies, 23 where: Zero-order is represented as the rate of the cumulative amount of drug released (Equation 1)…”

Section: Release Kineticsmentioning

confidence: 99%

HPMC Polymers and Xanthan Gum Assisted Development and Characterization of Stavudine Extended Release Floating Tablets

Gangane¹,

Pachpute²,

Mahapatra³

et al. 2021

IJPER

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Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-density formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. Materials and Methods: The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC). Results: The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped density, bulk density, Hausner's ratio, Carr's index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. Conclusion: This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.

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Natural and Synthetic Polymers Assisted Development of Lurasidone Hydrochloride Intranasal Mucoadhesive Microspheres

Cited by 14 publications

References 12 publications

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

Design and Development of Fenofibrate Solid Dispersions for Solubility Enhancement

Study an effect of various orgainic solvents for preparation of glipizide mucoadhesive microspheres

HPMC Polymers and Xanthan Gum Assisted Development and Characterization of Stavudine Extended Release Floating Tablets

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