Natural anti-obesity agents

Mohamed, Gamal A.; Ibrahim, Sabrin R. M.; Elkhayat, Ehab S.; Dine, Riham Salah El

doi:10.1016/j.bfopcu.2014.05.001

Cited by 179 publications

(149 citation statements)

References 155 publications

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“…PPARG, in turn, activates other adipogenic transcription factors like C/EBPα, adipocyte lipid binding protein (aP2) and lipoprotein lipase to bring about adipogenesis. PPARG presents itself as a good target for controlling obesity (Mohamed et al, ; Janderova, McNeil, Murrell, Mynatt, & Smith, ). This study has shown that SHAMstat3pg suppressed the mRNA expression of PPARG while inhibiting adipocyte formation (Figures a,b and 6b).…”

Section: Discussionmentioning

confidence: 99%

“…Dietary phytochemicals are being studied extensively for their use as multi-target, anti-obesity agents (Chawla et al, 2013). The phytochemicals could control obesity by: inhibiting of adipogenesis (Prathapan, Krishna, Lekshmi, Raghu, & Menon, 2012), inhibiting fatty acid biosynthesis (Zhao, Mao, et al, 2014), increasing energy expenditure and satiety (Mohamed, Ibrahim, Elkhayat, & El Dine, 2014), decreasing inflammation and oxidative stress (Abdel-Zaher, Abdel-Rahman, & ELwasei, 2011;Pinent et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

2018

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Obesity is a metabolic disorder that manifests into various forms. Recent studies have indicated that the pomegranate (Punica granatum) seed oil (PSO) has many biologically active components that help in controlling diet‐induced obesity and insulin resistance. However, its impact on the adipogenic differentiation of human adipose‐derived mesenchymal stem cells (HADMSC) remains unclear. Here we have attempted to study the anti‐obesity potential of SHAMstat3pg, a fatty acid composite extracted from PSO. It is composed of three dietary fatty acids: punicic acid [(9Z,11E,13Z)‐9,11,13‐Octadecatrienoic acid], oleic acid [Cis‐9‐Octadecenoic acid], and linoleic acid [(9Z,12Z)‐octadeca‐9,12‐dienoic acid]. In this study, we discuss the impact of the fatty acids on adipogenesis, inflammation, glucose uptake, and mitochondrial ATP production. The impact of SHAMstat3pg on the expression of various obesity‐associated protein and mRNA transcripts in HADMSC was also analyzed. The results indicate that exposure to 10 µg/ml of SHAMstat3pg (24 hr) inhibited adipogenesis of HADMSC, ameliorated inflammation, attenuated ATP production, and glucose uptake. Also, the extract favorably regulated the mRNA expression of the studied obesity‐associated gene transcripts. Practical applications SHAMstat3pg has the potential to serve as a multi‐targeted therapy for the management of obesity. This study demonstrated that the dietary fatty acids inhibited the differentiation of preadipocytes to adipocytes. SHAMstat3pg has also shown to have a favorable impact on the expression of the obesity‐linked proteins and genes in HADMSC that are associated with adipogenesis, inflammation, satiety, energy intake/expenditure (central and peripheral signaling molecules). The study gives an overview of the vast number of genes impacted by the treatment with SHAMstat3pg paving the way for future studies to demonstrate the exact mode of action of how dietary fatty acids can help manage obesity, insulin resistance, and type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

2018

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“…Both flavonoids and saponins are lipid lowering agents 27 . Flavonoids are antioxidants and may therefore reduce the oxidation of LDL cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of Raphanus sativus and Cassia angustifolia in Experimentally Induced Hyperlipidemia and Cardiovascular Risk Reduction

Jani¹,

Goswami²

2017

IJPTR

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:Hyperlipidemia is considered to be one of the greatest risk factors of cardiovascular diseases. Increase in number of hyperlipidemic and cardiac patients globally; emphasize the need of new therapies to reduce disease burden. The objective of current study is to investigate effect of Raphanus sativus and Cassia angustifolia extracts on experimentally induced hyperlipidemia and cardiovascular risk reduction. Phytochemical study of extracts was done as per standard procedures. As per Organisation for Economic Co-operation and Development (OECD) 420 guideline, single dose acute oral toxicity study performed using both extracts. Hyperlipidemia was induced in rats using Poloxamer 407 (P407) and blood samples were collected at 0, 24 and 48 h after P407 administration. Cardiovascular risk was assessed by analysing atherogenic indices. Results indicate that no sign of toxicity was observed with chosen extracts. Sgnificant reduction in total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), non HDL-C (non-high density lipoprotein cholesterol) and very low density lipoprotein (VLDL) was observed in extract treated groups of P407 induced hyperlipidemia. Significant decrease in atherogenic indices was observed in extract treated groups. These results were comparable with the results of Atorvastain treated group. On the basis of results, it is concluded that both the extracts of Raphanus sativus and Cassia angustifolia were found to ameliorate hyperlipidemia and risk of cardiovascular disorders.

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“…Eating a whole fresh pineapple (Ananas comosus, A. sativus) per day can decrease the body weight by 100 pounds on a pineapple regimen. Its content of bromelain enzyme helps to digest both proteins and fats 19 .…”

Section: Enzymatic Treatment Of Obesitymentioning

confidence: 99%

Untitled

2020

IJPSR

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The article focuses on the prevalence of obesity in India, increasing levels of childhood obesity, and the potential health hazards that result from obesity, thereby suggesting the necessary preventive measures and the prevailing natural and synthetic therapy that can help to cure the disease, thus spreading awareness about its severity and necessity for treatment. Obesity in India has reached epidemic proportions in the 21 st century, with morbid obesity affecting 5% of the country's population. About 3.4 million people die each year due to overweight and obesity. The numbers are only worsening with each passing year. Anti-obesity medication or weight loss drugs are pharmacological agents that reduce or control weight. These drugs alter one of the fundamental processes of the human body, weight regulation, by altering either appetite or absorption of calories. Thus proper preventive measures and medication can help in reducing the extent of the disease worldwide.

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Natural anti-obesity agents

Cited by 179 publications

References 155 publications

Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

Ameliorative effect of Raphanus sativus and Cassia angustifolia in Experimentally Induced Hyperlipidemia and Cardiovascular Risk Reduction

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